Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ana Mafalda, Santos"'
Autor:
Edward Jenkins, Markus Körbel, Caitlin O’Brien-Ball, James McColl, Kevin Y. Chen, Mateusz Kotowski, Jane Humphrey, Anna H. Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis, David Klenerman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
T cells can use TCR on microvilli to interact with peptide-MHC (pMHC) complexes on antigen presenting cells. Here the authors characterise how T cells use microvilli to interrogate reconstituted membranes for pMHC complexes and how this is regulated
Externí odkaz:
https://doaj.org/article/e163cebf0d034cc0b49fca7e959be290
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic development, but how they contribute to immune responses in the periphery is unclear. Coreceptors strengthen T-cell responses by many orders of magnitude – bey
Externí odkaz:
https://doaj.org/article/718d990dbd3f4b5ab090986fc4573a64
Autor:
Christopher Paluch, Ana Mafalda Santos, Consuelo Anzilotti, Richard J. Cornall, Simon J. Davis
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Antibodies that block the immune checkpoint receptors PD1 and CTLA4 have revolutionized the treatment of melanoma and several other cancers, but in the process, a new class of drug side effect has emerged—immune related adverse events. The observat
Externí odkaz:
https://doaj.org/article/673980b531654510a0d8ba4795ba7cb5
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The first step of the adaptive immune response involves the interaction of T cells that express T-cell receptors (TCRs) with peptide-loaded major histocompatibility complexes expressed by antigen-presenting cells (APCs). Exactly how this leads to act
Externí odkaz:
https://doaj.org/article/f782c0a93fd944d098614a91034699df
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The immune system serves as a crucial line of defense from infection and cancer, while also contributing to tissue homeostasis. Communication between immune cells is mediated by small soluble factors called cytokines, and also by direct cellular inte
Externí odkaz:
https://doaj.org/article/40c2a99cdf97412bb302d1b9b9fcd0df
Autor:
Alexander M. Mørch, Falk Schneider, Edward Jenkins, Ana Mafalda Santos, Scott E. Fraser, Simon J. Davis, Michael L. Dustin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(49)
The sensitivity of the αβ T-cell receptor (TCR) is enhanced by the coreceptors CD4 and CD8αβ, which are expressed primarily by cells of the helper and cytotoxic T-cell lineages, respectively. The coreceptors bind to major histocompatibility compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e339daba8921487f39a990137f9787a3
https://pubmed.ncbi.nlm.nih.gov/36454761
https://pubmed.ncbi.nlm.nih.gov/36454761
Autor:
Catarina Bessa-Pereira, Markéta Bocková, Rita F Santos, Ana Mafalda Santos, Mafalda Martins de Araújo, Liliana Oliveira, Jiří Homola, Alexandre M Carmo
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The scavenger receptor cysteine-rich (SRCR) family comprises a group of membrane-attached or secreted proteins that contain one or more modules/domains structurally similar to the membrane distal domain of type I macrophage scavenger receptor. Althou
Externí odkaz:
https://doaj.org/article/842c137e2b0f425b89889f006070c802
Autor:
Markus Körbel, Edward Jenkins, James T. McColl, Caitlin O'Brien-Ball, Anna H. Lippert, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis, David Klenerman
Publikováno v:
Biophysical Journal. 121:150a-151a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf657bd8cb5c467ce52eb7d41796ceb
https://doi.org/10.1016/j.bpj.2021.11.1976
https://doi.org/10.1016/j.bpj.2021.11.1976
Autor:
Lukas Sušac, Mai T. Vuong, Christoph Thomas, Sören von Bülow, Caitlin O’Brien-Ball, Ana Mafalda Santos, Ricardo A. Fernandes, Gerhard Hummer, Robert Tampé, Simon J. Davis
Publikováno v:
Cell
The T cell receptor (TCR) expressed by T lymphocytes initiates protective immune responses to pathogens and tumors. To explore the structural basis of how TCR signaling is initiated when the receptor binds to peptide-loaded major histocompatibility c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cdf4904f7be9ad5b6aeb68e5d3383e0
https://doi.org/10.1016/j.cell.2022.07.010
https://doi.org/10.1016/j.cell.2022.07.010