Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ana M. Pérez-López"'
Publikováno v:
JACS Au, Vol 3, Iss 8, Pp 2123-2130 (2023)
Externí odkaz:
https://doaj.org/article/13715b885c45479694ca35f0f25b3ac1
Autor:
Belén Rubio-Ruiz, Ana M. Pérez-López, Laura Uson, M. Carmen Ortega-Liebana, Teresa Valero, Manuel Arruebo, Jose L. Hueso, Victor Sebastian, Jesus Santamaria, Asier Unciti-Broceta
Publikováno v:
Rubio Ruiz, B, Perez-Lopez, A, Uson, L, Ortega Liebana, M C, Valero, T, Arruebo, M, Hueso, J L, Sebastian, V, Santamaría, J & Unciti-Broceta, A 2023, ' In Cellulo Bioorthogonal Catalysis by Encapsulated AuPd Nanoalloys. Overcoming Intracellular Deactivation ', Nano Letters, vol. 23, no. 3, pp. 804-811 . https://doi.org/10.1021/acs.nanolett.2c03593
Bioorthogonal metallocatalysis has opened up a xenobiotic route to perform nonenzymatic catalytic transformations in living settings. Despite their promising features, most metals are deactivated inside cells by a myriad of reactive biomolecules, inc
Publikováno v:
Pérez-López, A M, Belsom, A, Fiedler, L, Xin, X & Rappsilber, J 2023, ' Dual-bioorthogonal catalysis by a palladium peptide complex ', Journal of Medicinal Chemistry . https://doi.org/10.1021/acs.jmedchem.2c01689
Artificial metalloenzymes (ArMs) enrich bioorthogonal chemistry with new-to-nature reactions while limiting metal deactivation and toxicity. This enables biomedical applications such as activating therapeutics in situ. However, while combination ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ace34c25ac29a71250f03b32b353ee
https://hdl.handle.net/20.500.11820/db087640-7de9-4b87-9f01-6f2ad919c7e6
https://hdl.handle.net/20.500.11820/db087640-7de9-4b87-9f01-6f2ad919c7e6
Developing Pd(ii ) based amphiphilic polymeric nanoparticles for pro-drug activation in complex media
Autor:
Anjana Sathyan, Stephen Croke, Ana M. Pérez-López, Bas F. M. de Waal, Asier Unciti-Broceta, Anja R. A. Palmans
Publikováno v:
Molecular Systems Design and Engineering, 7(12). Royal Society of Chemistry
Sathyan, A, Croke, S, Perez-Lopez, A, de Waal, B, Unciti-Broceta, A & Palmans, A R A 2022, ' Developing Pd(II) based amphiphilic polymeric nanoparticles for pro-drug activation in complex media ', Molecular Systems Design & Engineering . https://doi.org/10.1039/D2ME00173J
Molecular Systems Design & Engineering
Sathyan, A, Croke, S, Perez-Lopez, A, de Waal, B, Unciti-Broceta, A & Palmans, A R A 2022, ' Developing Pd(II) based amphiphilic polymeric nanoparticles for pro-drug activation in complex media ', Molecular Systems Design & Engineering . https://doi.org/10.1039/D2ME00173J
Molecular Systems Design & Engineering
Novel approaches to targeted cancer therapy that combine improved efficacy of current chemotherapies while minimising side effects are highly sought after. The development of single-chain polymeric nanoparticles (SCPNs) as bio-orthogonal catalysts fo
Autor:
Catherine, Adam, Thomas L, Bray, Ana M, Pérez-López, Ee Hong, Tan, Belén, Rubio-Ruiz, Daniel J, Baillache, Douglas R, Houston, Mark J, Salji, Hing Y, Leung, Asier, Unciti-Broceta
Publikováno v:
Journal of medicinal chemistry. 65(1)
5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from colorectal and pancreatic cancer. Because of its suboptimal route of administration and do
Autor:
Catherine Adam, Thomas L. Bray, Ana M. Pérez-López, Ee Hong Tan, Belén Rubio-Ruiz, Daniel J. Baillache, Douglas R. Houston, Mark J. Salji, Hing Y. Leung, Asier Unciti-Broceta
Publikováno v:
Adam, C, Bray, T, Perez-Lopez, A, Tan, E H, Rubio Ruiz, B, Baillache, D, Houston, D R, Salji, M J, Leung, H Y & Unciti-Broceta, A 2022, ' A 5-FU precursor designed to evade anabolic and catabolic drug pathways and activated by Pd chemistry in vitro and in vivo ', Journal of Medicinal Chemistry, vol. 65, no. 1, pp. 552-561 . https://doi.org/10.1021/acs.jmedchem.1c01733
5-Fluorouracil (5-FU) is an antineoplastic antimetabolite that is widely administered to cancer patients by bolus injection, especially to those suffering from colorectal and pancreatic cancer. Because of its suboptimal route of administration and do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5f8ba00f4b02191c9fbb77c71335c2
https://hdl.handle.net/10668/22589
https://hdl.handle.net/10668/22589
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0153209 (2016)
The in situ detection of caspase-3 activity has applications in the imaging and monitoring of multiple pathologies, notably cancer. A series of cell penetrating FRET-based fluorogenic substrates were designed and synthesised for the detection of casp
Externí odkaz:
https://doaj.org/article/7003d7af2e1248bc975c2a2dcf95a763
Autor:
Belén Rubio-Ruiz, Carmen Torres-Sanchez, Ana M. Pérez-López, Mohammad N. Alqahtani, Asier Unciti-Broceta
Publikováno v:
Torres-sánchez, C, Pérez-lópez, A M, Alqahtani, M N, Unciti-broceta, A & Rubio-ruiz, B 2018, ' Design and manufacture of functional catalyst-carrier structures for the bioorthogonal activation of anticancer agents ', New journal of chemistry . https://doi.org/10.1039/C8NJ05704D
Novel palladium (Pd)-loaded titanium (Ti) devices with high biocompatibility and catalytic activity were prepared using a range of fabrication methods such as powder metallurgy (i.e. sintering with and without space-holder), sputtering, pulsed laser
Publikováno v:
Rubio-ruiz, B, Pérez-lópez, A M, Sebastián, V & Unciti-broceta, A 2021, ' A minimally-masked inactive prodrug of panobinostat that is bioorthogonally activated by gold chemistry ', Bioorganic and Medicinal Chemistry, pp. 116217 . https://doi.org/10.1016/j.bmc.2021.116217
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
The recent incorporation of Au chemistry in the bioorthogonal toolbox has opened up new opportunities to deliver biologically independent reactions in living environments. Herein we report that the O-propargylation of the hydroxamate group of the pot
Autor:
Asier Unciti-Broceta, Victor Sebastian, Belén Rubio-Ruiz, Jesus Santamaria, Ana M. Pérez-López, Pilar Martin-Duque, María Sancho-Albero, Manuel Arruebo
Publikováno v:
Sebastian, V, Sancho-Albero, M, Arruebo, M, Perez-Lopez, A, Rubio Ruiz, B, Martin-Duque, P, Unciti-Broceta, A & Santamaría, J 2020, ' Non-destructive production of exosomes loaded with ultrathin Palladium nanosheets for targeted bioorthogonal catalysis ', Nature Protocols . https://doi.org/10.1038/s41596-020-00406-z
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
The use of exosomes as selective delivery vehicles of therapeutic agents, such as drugs or hyperthermia-capable nanoparticles, is being intensely investigated on account of their preferential tropism toward their parental cells. However, the methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899233b3dd4df8597e640790032ea2a7
https://hdl.handle.net/10668/16682
https://hdl.handle.net/10668/16682