Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Ana M. Metelo"'
1
Akademický článek
Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma
Autor: Haley R. Noonan, Ana M. Metelo, Caramai N. Kamei, Randall T. Peterson, Iain A. Drummond, Othon Iliopoulos
Publikováno v: Disease Models & Mechanisms, Vol 9, Iss 8, Pp 873-884 (2016)
Patients with von Hippel–Lindau (VHL) disease harbor a germline mutation in the VHL gene leading to the development of several tumor types including clear cell renal cell carcinoma (ccRCC). In addition, the VHL gene is inactivated in over 90% of sp
Externí odkaz: https://doaj.org/article/e38cdf75c43e40638bacc4db42df2bc9
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2
Allogeneic Anti-BCMA CAR T Cells Are Superior to Multiple Myeloma-derived CAR T Cells in Preclinical Studies and May Be Combined with Gamma Secretase Inhibitors
Autor: Ana M. Metelo, Agnieszka Jozwik, Le Anh Luong, Delaney Dominey-Foy, Charlotte Graham, Charlotte Attwood, Shafqat Inam, Alan Dunlop, Katy Sanchez, Kirsty Cuthill, Carmel Rice, Matthew Streetly, Trevor Bentley, Bijan Boldajipour, Cesar Sommer, Barbra Sasu, Reuben Benjamin
Publikováno v: Cancer Research Communications. 2:158-171
Multiple myeloma remains an incurable plasma cell malignancy despite the rapidly evolving treatment landscape. Chimeric antigen receptor T cells targeted against BCMA have recently shown great promise in relapsed refractory multiple myeloma; however,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d7103549aa9e3ad5173e0c5f540c585
https://doi.org/10.1158/2767-9764.crc-21-0157
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6
Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction
Autor: Evanna L. Mills, Benjamin A. Olenchock, Edward T. Chouchani, Surendra R. Punganuru, Wen Zhou, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Andrew M. Intlekofer, Iiro Taneli Helenius, Yiyun Zhang, Othon Iliopoulos, Eugene P. Rhee, Jing-Ruey J. Yeh, Hanumantha Rao Madala, Kyung Bo Kim
Publikováno v: Cancer Res
Under conditions of inherent or induced mitochondrial dysfunction, cancer cells manifest overlapping metabolic phenotypes, suggesting that they may be targeted via a common approach. Here, we use multiple oxidative phosphorylation (OXPHOS)–competen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b9ed999e56b7e08a5bf81aeb2ec0f6
https://doi.org/10.1158/0008-5472.can-20-0246
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8
Hemangioblastomas of the central nervous system
Autor: Othon Iliopoulos, Ana M. Metelo
Publikováno v: Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease ISBN: 9780128138663
Hemangioblastomas (HBs) are vascular tumors of the central nervous system that develop in patients with Von Hippel–Lindau (VHL) disease or sporadically. Loss-of-VHL tumor suppressor gene is a hallmark of both types of HBs. The tumors comprise tumor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc1595270b7c1bfb1ca7eb0d8762e4e
https://doi.org/10.1016/b978-0-12-813866-3.00015-1
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9
Metabolic effects of VO(dmpp)2 ¿ an ex vivo1H-HRMAS NMR study to unveil its pharmacological properties
Autor: M. Margarida C. A. Castro, Pilar López-Larrubia, Ana M. Metelo, Nuria Arias-Ramos
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The pharmacological action of the V(IV) compound VO(dmpp)2 was previously evaluated in vivo using obese pre-diabetic Zucker rats treated with this compound for four weeks. Besides the promising results regarding biological parameters indicative of in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef58d0d5eb4384124d7cabcb73c0fda
http://hdl.handle.net/10261/207031
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10
Loss ofvhlin the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma
Autor: Caramai N. Kamei, Othon Iliopoulos, Ana M. Metelo, Haley R. Noonan, Randall T. Peterson, Iain A. Drummond
Publikováno v: Disease Models & Mechanisms, Vol 9, Iss 8, Pp 873-884 (2016)
Disease Models & Mechanisms
Patients with von Hippel–Lindau (VHL) disease harbor a germline mutation in the VHL gene leading to the development of several tumor types including clear cell renal cell carcinoma (ccRCC). In addition, the VHL gene is inactivated in over 90% of sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca64adb664f7fb463b24bf2e99aaeec
https://doi.org/10.1242/dmm.024380
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