Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism

Autor: M. Consuelo Jiménez, Daniel Limones-Herrero, Miguel A. Miranda, Ana M. Martínez-Reig, Guillermo Garcia-Lainez, Inmaculada Andreu

Publikováno v: Toxicology and applied pharmacology
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia

[EN] Diclofenac (DCF) can cause adverse reactions such as gastrointestinal, renal and cardiovascular disorders; therefore, topical administration may be an attractive alternative to the management of local pain in order to avoid these side effects. H

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