Functional basis of electron transport within photosynthetic complex I

Autor: Katherine H. Richardson, John J. Wright, Mantas Šimėnas, Jacqueline Thiemann, Ana M. Esteves, Gemma McGuire, William K. Myers, John J. L. Morton, Michael Hippler, Marc M. Nowaczyk, Guy T. Hanke, Maxie M. Roessler

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)

Photosynthetic Complex I (PS-CI) is proposed to couple ferredoxin oxidation and plastoquinone reduction to proton pumping across thylakoid membranes. Here the authors determine the reduction potentials of the iron-sulphur clusters of PS-CI and thus t

Externí odkaz: https://doaj.org/article/5f14541d7c63407691c5fb2760025b0b

Combination of Interleukin-15 With a STING Agonist, ADU-S100 Analog: A Potential Immunotherapy for Prostate Cancer

Autor: Ana M. Esteves, Efthymia Papaevangelou, Prokar Dasgupta, Christine Galustian

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

Prostate cancer is the second most commonly diagnosed cancer in men with mortality rates, overtaking those for breast cancer in the last 2 years in the UK. Despite advances in prostate cancer treatments, over 25% of men do not survive over 5 years wi

Externí odkaz: https://doaj.org/article/f7dd0c3fa83542759b7d82b7212e43da

Cytotopic (Cyto-) IL-15 as a New Immunotherapy for Prostate Cancer: Recombinant Production in Escherichia coli and Purification

Autor: Dorota Smolarek, Christine Galustian, Ana M. Esteves, Efthymia Papaevangelou, Prokar Dasgupta

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

Interleukin-15 (IL-15) is a cytokine previously suggested as a potential immunotherapy for cancer treatment. IL-15 can effectively reduce tumor growth in many preclinical tumor models including prostate cancer. This is due to its ability to expand an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d94944cc613267b2e4af8ef4c1dea61

Prostate cancer cells enhance interleukin-15-mediated expansion of NK cells

Autor: Christina Sakellariou, Giulio Giustarini, Richard A. G. Smith, Dorota Smolarek, Oussama Elhage, Ana M. Esteves, Efthymia Papaevangelou, Prokar Dasgupta, Christine Galustian

Publikováno v: Sakellariou, C, Elhage, O, Papaevangelou, E, Giustarini, G, Da Silva Esteves, A M E, Smolarek, D, Smith, R, Dasgupta, P & Galustian, C 2019, ' Prostate cancer cells enhance interleukin-15-mediated expansion of NK cells ', BJU International, vol. 125, no. 1, pp. 89-102 . https://doi.org/10.1111/bju.14893

Objectives To identify cytokines that can activate and expand NK cells in the presence of prostate cancer cells in order to determine whether these agents may be useful in future intra-tumoural administration in pre-clinical and clinical prostate can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ad00e0baa362e5cd66f81264f47115
https://pubmed.ncbi.nlm.nih.gov/34096169

Abstract 4070: Combination of Interleukin-15 with a STING (Stimulator of Interferon Gene) agonist: A potential immunotherapy for prostate cancer

Autor: Richard A. G. Smith, Prokar Dasgupta, Christine Galustian, Efthymia Papaevangelou, Ana M. Esteves

Publikováno v: Cancer Research. 79:4070-4070

Introduction & Objectives: Prostate cancer (PC) is the second most commonly diagnosed cancer in men and the eighth leading cause of cancer-related mortality in the world. The only successful immunotherapy for the disease (ProvengeTM) only extends lif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::260d4fb04566199c0d9300f7204247dc
https://doi.org/10.1158/1538-7445.am2019-4070