Výsledky vyhledávání - "Ana M. Borras"

Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer

Autor: Lewis C. Cantley, George N. Naumov, John V. Heymach, Ana M. Borras, Bruce E. Johnson, Christopher Michael Gale, Toru Mukohara, Emily T Jarrell, Beow Y. Yeap, Pasi A. Jänne, Jeffrey A. Engelman, Jason Sun, Kreshnik Zejnullahu, Sean Tracy, Xiaojun Zhao, Eugene Lifshits

Publikováno v: Journal of Clinical Investigation. 116:2695-2706

EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but has not been shown to be sufficient to render EGFR mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4505db1746fa10a86c973b6ef42671d8
https://doi.org/10.1172/jci28656

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A Rapid and Sensitive Enzymatic Method for Epidermal Growth Factor Receptor Mutation Screening

Autor: Elizabeth A. Maher, Balazs Halmos, Matthew Meyerson, Jeffrey C. Lee, Neal I. Lindeman, Victoria A. Joshi, Robert J. Distel, Pasi A. Jänne, Andrew M. Rogers, Ana M. Borras, Bruce E. Johnson, Hema Liyanage, Yanan Kuang

Publikováno v: Clinical Cancer Research. 12:751-758

Purpose: Mutations in the epidermal growth factor receptor (EGFR) are associated with clinical and radiographic responses to EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Currently available methods of EGFR mutation detection rely on direc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d824e7e2c0ae92a3ad061e5556be29e
https://doi.org/10.1158/1078-0432.ccr-05-2047

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Early Postnatal Cardiac Changes and Premature Death in Transgenic Mice Overexpressing a Mutant Form of Serum Response Factor

Autor: Pamela L. Sheridan, Konstantin Khrapko, Maxwell C. Furr, Joel A. Lawitts, Xiaomin Zhang, Ana M. Borras, Jianyuan Chai, Ravi P. Misra, Gohar Azhar, Jeanne Y. Wei

Publikováno v: Journal of Biological Chemistry. 276:40033-40040

Serum response factor (SRF) is a key regulator of a number of extracellular signal-regulated genes important for cell growth and differentiation. A form of the SRF gene with a double mutation (dmSRF) was generated. This mutation reduced the binding a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec61bb759579dfadec28f841e4764071
https://doi.org/10.1074/jbc.m104934200

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Altered Regulation of Cyclin G in Human Breast Cancer and Its Specific Localization at Replication Foci in Response to DNA Damage in p53+/+ Cells

Autor: Stuart A. Aaronson, Corinne L. Reimer, Sam W. Lee, Siavash K. Kurdistani, Ana M. Borras, Jennifer R. Garreau, Mirra Chung

Publikováno v: Journal of Biological Chemistry. 274:11022-11029

Cyclin G, a recent addition to the cyclin family, was initially identified in screens for new src kinase family members and soon thereafter by differential screening for transcriptional targets of the tumor suppressor gene, p53. We have identified cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2f12ac001052e31298d014b52697d4
https://doi.org/10.1074/jbc.274.16.11022

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Binding of the Ubiquitous Cellular Transcription Factors Sp1 and Sp3 to the ZI Domains in the Epstein–Barr Virus Lytic Switch BZLF1 Gene Promoter

Autor: Samuel H. Speck, Shaofan Liu, Guntram Suske, Pingfan Liu, Ana M. Borras

Publikováno v: Virology. 228(1):11-18

Induction of the Epstein-Barr virus lytic cycle in latently infected B cells requires the expression of the immediate-early lytic gene BZLF1. We have previously identified several cis-elements within the BZLF1 promoter that are required for induction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24964f3e31c8bfe6e4e5ac1fb1e7568c

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Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member

Autor: Ana M. Borras, Talal A. Chatila, Pingfan Liu, Shaofan Liu, Samuel H. Speck

Publikováno v: The EMBO Journal. 16:143-153

Induction of the Epstein-Barr virus (EBV) lytic cycle by crosslinking surface immunoglobulin is inhibited by the immunosuppressants cyclosporin A (CsA) and FK506. This correlates with the ability of CsA to inhibit Ca2+-dependent transcription of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258722c788c345dc9240893637d9102f
https://doi.org/10.1093/emboj/16.1.143

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Identification of novel HER2 splice variants in breast cancer

Autor: Robert J. Distel, Ana M. Borras, Yanan Kuang, Andrew M. Rogers, Ian E. Krop, Ludmila Flores

Publikováno v: Journal of Clinical Oncology. 26:22010-22010

22010 Background: De novo and acquired resistance of HER2+ breast cancer (HBC) totrastuzumab (T) is an important clinical problem, yet the molecular basis underlying resistance is not well understo...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::915abfe15ef74fed8c619c93eb124024
https://doi.org/10.1200/jco.2008.26.15_suppl.22010

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Detection of clinically significant mutations in the epidermal growth factor receptor missed by direct sequencing using a highly sensitive DNA endonuclease

Autor: Alison J. Holmes, Yanan Kuang, M. Taron, Giuseppe Giaccone, Victoria A. Joshi, Pasi A. Jänne, M. Gallegos Ruiz, Andrew M. Rogers, Ana M. Borras, Robert J. Distel

Publikováno v: Journal of Clinical Oncology. 24:10054-10054

10054 Background: Mutations in the epidermal growth factor receptor (EGFR) are associated with sensitivity and resistance to EGFR inhibitors gefitinib and erlotinib in patients with non-small cell lung carcinoma (NSCLC). Direct sequencing is currentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2de8d9f1e2a3801a12323aaf7ba7313a
https://doi.org/10.1200/jco.2006.24.18_suppl.10054

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