Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ana M Tomás"'
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201747 (2018)
Leishmania parasites cause a set of neglected tropical diseases with considerable public health impact, the leishmaniases, which are often fatal if left untreated. Since current treatments for the leishmaniases exhibit high toxicity, low efficacy and
Externí odkaz:
https://doaj.org/article/93159854d4ff402a92263e4f3507f1a1
Autor:
Helena Castro, Filipa Teixeira, Susana Romao, Mariana Santos, Tânia Cruz, Manuela Flórido, Rui Appelberg, Pedro Oliveira, Frederico Ferreira-da-Silva, Ana M Tomás
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002325 (2011)
Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leishmania and related trypanosomatids, which lack catalase and selenium-glutathione peroxidases, the discovery of this family of enzymes provided the mol
Externí odkaz:
https://doaj.org/article/570e7538ecc04c528517a049fc35542d
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12607 (2010)
Tryparedoxins (TXNs) are oxidoreductases unique to trypanosomatids (including Leishmania and Trypanosoma parasites) that transfer reducing equivalents from trypanothione, the major thiol in these organisms, to sulfur-dependent peroxidases and other d
Externí odkaz:
https://doaj.org/article/4c85c06044bc40729d2c1dcacd9b32da
Autor:
Carlos F. M. Silva, Teresa Leão, Filipa Dias, Ana M. Tomás, Diana C. G. A. Pinto, Eduardo F. T. Oliveira, Ana Oliveira, Pedro A. Fernandes, Artur M. S. Silva
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 669 (2023)
Leishmaniasis is one of the most neglected diseases in modern times, mainly affecting people from developing countries of the tropics, subtropics and the Mediterranean basin, with approximately 350 million people considered at risk of developing this
Externí odkaz:
https://doaj.org/article/28f50d7da90944ec8081fb178b064778
Autor:
Filipe Marques, Sílvia Vale-Costa, Tânia Cruz, Joana Moreira Marques, Tânia Silva, João Vilares Neves, Sofia Cortes, Ana Fernandes, Eduardo Rocha, Rui Appelberg, Pedro Rodrigues, Ana M. Tomás, Maria Salomé Gomes
Publikováno v:
Parasites & Vectors, Vol 8, Iss 1, Pp 1-12 (2015)
Abstract Background Visceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L. infantum is the commonest agent of visc
Externí odkaz:
https://doaj.org/article/dca6a0bfb58c45f5949929d36e8dafdf
Autor:
Zeynep Islek, Mehmet Hikmet Ucisik, Elif Keskin, Bilgesu Onur Sucu, Ana G. Gomes‐Alves, Ana M. Tomás, Mustafa Guzel, Fikrettin Sahin
Publikováno v:
Frontiers in Nanotechnology, Vol 3 (2022)
Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on macrophages plus poor aqueou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4ddfb43acaf390cb01c43abcfd17cb
https://hdl.handle.net/20.500.13055/197
https://hdl.handle.net/20.500.13055/197
Autor:
Mafalda Sousa, Margarida Duarte, Maria Inês Rocha, Helena Castro, Ana M. Tomás, Filipa Dias, Mariana Resende
Publikováno v:
ACS Infectious Diseases. 6:1643-1649
Leishmania infantum (L. infantum) and Leishmania major (L. major) are phylogenetically related protozoan parasites that cause different pathologies in humans (visceral and cutaneous infections, res...
Autor:
Francisca Lopes, Helena Castro, Ana M. Tomás, Rui Moreira, Tânia Cruz, Ana Georgina Gomes-Alves, Ana S. Ressurreição, Margarida Duarte
Publikováno v:
Antimicrobial Agents and Chemotherapy. 65
Leishmaniasis is one of the most challenging neglected tropical diseases and remains a global threat to public health. Currently available therapies for leishmaniases present significant drawbacks and are rendered increasingly inefficient due to para
Autor:
Ana Georgina, Gomes-Alves, Margarida, Duarte, Tânia, Cruz, Helena, Castro, Francisca, Lopes, Rui, Moreira, Ana S, Ressurreição, Ana M, Tomás
Publikováno v:
Antimicrob Agents Chemother
Leishmaniasis is one of the most challenging neglected tropical diseases and remains a global threat to public health. Currently available therapies for leishmaniases present significant drawbacks and are rendered increasingly inefficient due to para
Autor:
Graça Alexandre-Pires, David Santos-Mateus, R. Alves-Azevedo, Telmo Nunes, Ana Valério-Bolas, Marcos Santos, I. Pereira da Fonseca, S. Lopes-Ventura, Armanda Rodrigues, Ana M. Tomás, Dário Ligeiro, Maria Pereira, Mariana Rafael-Fernandes, Gabriela Santos-Gomes
Publikováno v:
Parasitology. 146:753-764
Hepatocytes constitute the majority of hepatic cells, and play a key role in controlling systemic innate immunity,viapattern-recognition receptors (PRRs) and by synthesizing complement and acute phase proteins.Leishmania infantum, a protozoan parasit