Výsledky vyhledávání - "Ana M Romão"

Akademický článek

Endocannabinoid system in cardiovascular disorders - new pharmacotherapeutic opportunities

Autor: Pedro Cunha, Ana M Romão, Filipa Mascarenhas-Melo, Helena M Teixeira, Flávio Reis

Publikováno v: Journal of Pharmacy and Bioallied Sciences, Vol 3, Iss 3, Pp 350-360 (2011)

The long history of Cannabis sativa had its development stimulated and oriented for medicine after the discovery and chemical characterization of its main active ingredient, the 9-tetrahydrocannabinol (9-THC). Consequently, a binding site for 9-THC w

Externí odkaz: https://doaj.org/article/da455bf16ebb4cb3b41728b3d0b78d52

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Akademický článek

Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Autor: Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. Romão, Elisabetta Grillo, Jason K. H. Lai, Stefan Günther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

The glycolytic enzyme pyruvate kinase M2 (PKM2) is required for nucleotide synthesis and cell proliferation. Using gene expression and metabolomics analyses, the authors here show that PKM2 regulates methionine metabolism and DNA methylation in endot

Externí odkaz: https://doaj.org/article/193983107e6a406b9727e989c6776bf0

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Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells

Autor: Sylvia Jeratsch, Carsten Kuenne, Ana M Romão, Oliver A. Stone, Kerstin Wilhelm, Didier Y.R. Stainier, Massimo M. Santoro, Mohamed A. El-Brolosy, Thomas Braun, Stefan Günther, Jason W. Locasale, Michael Potente, Xiaojing Liu, Elisabetta Grillo, I-Ching Lee, Jason Kuan Han Lai

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications

Despite their inherent proximity to circulating oxygen and nutrients, endothelial cells (ECs) oxidize only a minor fraction of glucose in mitochondria, a metabolic specialization that is poorly understood. Here we show that the glycolytic enzyme pyru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a512bf213dbba496484d7c8619d8e8d5
https://doaj.org/article/193983107e6a406b9727e989c6776bf0

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Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule

Autor: Hermann Bihler, Carlos M. Farinha, Martin Mense, Zhiwei Cai, Jia Liu, Nikhil T. Awatade, Y. Cheng, Margarida D. Amaral, Dayna Mercadante, Ana M Romão, Isaac Musisi, Yiting Wang, David N. Sheppard, Walailak Jantarajit

Publikováno v: British Journal of Pharmacology. 175:1017-1038

Background and purpose Rescue of F508del-cystic fibrosis (CF) transmembrane conductance regulator (CFTR), the most common CF mutation, requires small molecules that overcome protein processing, stability and channel gating defects. Here, we investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::293fbe18d1ec28f893de1ef4e4072561
https://doi.org/10.1111/bph.14141

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Partial rescue of F508del-cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual-acting small molecule

Autor: Jia, Liu, Hermann, Bihler, Carlos M, Farinha, Nikhil T, Awatade, Ana M, Romão, Dayna, Mercadante, Yi, Cheng, Isaac, Musisi, Walailak, Jantarajit, Yiting, Wang, Zhiwei, Cai, Margarida D, Amaral, Martin, Mense, David N, Sheppard

Publikováno v: British journal of pharmacology. 175(7)

BACKGROUND AND PURPOSE: Rescue of F508del‐cystic fibrosis (CF) transmembrane conductance regulator (CFTR), the most common CF mutation, requires small molecules that overcome protein processing, stability and channel gating defects. Here, we invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5b8f40f3539c32ff9642d037c724191
https://pubmed.ncbi.nlm.nih.gov/29318594

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Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model

Autor: José, Sereno, Ana M, Romão, Belmiro, Parada, Patrícia, Lopes, Eugénia, Carvalho, Frederico, Teixeira, Flávio, Reis

Publikováno v: Journal of Pharmacology & Pharmacotherapeutics

Objective: To compare the cardiorenal effects of early versus late cyclosporine (CsA) to sirolimus (SRL) conversion, using a novel animal model that mimics these protocols used in the clinical practice, and focusing on blood pressure, heart rate (HR)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e168eefa04c2d450656152aa986e6eb
https://pubmed.ncbi.nlm.nih.gov/22629089

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