Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ana M Maestre"'
Autor:
Shashank Tripathi, Vinod R M T Balasubramaniam, Julia A Brown, Ignacio Mena, Alesha Grant, Susana V Bardina, Kevin Maringer, Megan C Schwarz, Ana M Maestre, Marion Sourisseau, Randy A Albrecht, Florian Krammer, Matthew J Evans, Ana Fernandez-Sesma, Jean K Lim, Adolfo García-Sastre
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006258 (2017)
Zika virus (ZIKV) is a mosquito borne flavivirus, which was a neglected tropical pathogen until it emerged and spread across the Pacific Area and the Americas, causing large human outbreaks associated with fetal abnormalities and neurological disease
Externí odkaz:
https://doaj.org/article/219cc2204ce745298f85c5ac7cb53e57
Autor:
Claudia V Filomatori, Juan M Carballeda, Sergio M Villordo, Sebastian Aguirre, Horacio M Pallarés, Ana M Maestre, Irma Sánchez-Vargas, Carol D Blair, Cintia Fabri, Maria A Morales, Ana Fernandez-Sesma, Andrea V Gamarnik
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006265 (2017)
The Flavivirus genus includes a large number of medically relevant pathogens that cycle between humans and arthropods. This host alternation imposes a selective pressure on the viral population. Here, we found that dengue virus, the most important vi
Externí odkaz:
https://doaj.org/article/8ee8b1c0f0b64fd1abae23782376e76d
Autor:
Amanda M Opaluch, Monika Schneider, Chih-yuan Chiang, Quy T Nguyen, Ana M Maestre, Lubbertus C F Mulder, Ismael Secundino, Paul D De Jesus, Renate König, Viviana Simon, Victor Nizet, Graham MacLeod, Susannah Varmuza, Ana Fernandez-Sesma, Sumit K Chanda
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89284 (2014)
Innate immune sensors such as Toll-like receptors (TLRs) differentially utilize adaptor proteins and additional molecular mediators to ensure robust and precise immune responses to pathogen challenge. Through a gain-of-function genetic screen, we ide
Externí odkaz:
https://doaj.org/article/8a1d8360ade647799e0b14344a763138
Autor:
Juliet Morrison, Maudry Laurent-Rolle, Ana M Maestre, Ricardo Rajsbaum, Giuseppe Pisanelli, Viviana Simon, Lubbertus C F Mulder, Ana Fernandez-Sesma, Adolfo García-Sastre
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003265 (2013)
An estimated 50 million dengue virus (DENV) infections occur annually and more than forty percent of the human population is currently at risk of developing dengue fever (DF) or dengue hemorrhagic fever (DHF). Despite the prevalence and potential sev
Externí odkaz:
https://doaj.org/article/c2c13699c8a14e3d9f30cc12b62340bf
Autor:
Sebastian Aguirre, Ana M Maestre, Sarah Pagni, Jenish R Patel, Timothy Savage, Delia Gutman, Kevin Maringer, Dabeiba Bernal-Rubio, Reed S Shabman, Viviana Simon, Juan R Rodriguez-Madoz, Lubbertus C F Mulder, Glen N Barber, Ana Fernandez-Sesma
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002934 (2012)
Dengue virus (DENV) is a pathogen with a high impact on human health. It replicates in a wide range of cells involved in the immune response. To efficiently infect humans, DENV must evade or inhibit fundamental elements of the innate immune system, n
Externí odkaz:
https://doaj.org/article/78139064b4bc4ba996ad45f43d5b6e8a
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46768 (2012)
Infectious bursal disease virus (IBDV) is an avian pathogen responsible for an acute immunosuppressive disease that causes major losses to the poultry industry. Despite having a bipartite dsRNA genome, IBDV, as well as other members of the Birnavirid
Externí odkaz:
https://doaj.org/article/f95679e4176547a5aea7e1b91d9a0eae
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20972 (2011)
Toroviruses are gastroenteritis causing agents that infect different animal species and humans. To date, very little is known about how toroviruses cause disease. Here, we describe for the first time that the prototype member of this genus, the equin
Externí odkaz:
https://doaj.org/article/3de8db31f6564d0981733e03cd804577
Autor:
Sonja Schmid, Juliet Morrison, Giuseppe Pisanelli, David A. Stein, Ana M. Maestre, Gijs A. Versteeg, Ana Fernandez-Sesma, Maudry Laurent-Rolle, Hong M. Moulton, Ricardo Rajsbaum, Benjamin R. tenOever, Adolfo García-Sastre, Alan Belicha-Villanueva, Carles Martínez-Romero, Jenish R. Patel, Lisa Miorin
Publikováno v:
Immunity, vol 40, iss 6
SummaryType I interferons (IFN-I) are essential antiviral cytokines produced upon microbial infection. IFN-I elicits this activity through the upregulation of hundreds of IFN-I-stimulated genes (ISGs). The full breadth of ISG induction demands activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b77a22ce63e515b98567eb1f8b6e65a
https://doi.org/10.1016/j.immuni.2014.04.018
https://doi.org/10.1016/j.immuni.2014.04.018
Autor:
Ana M. Maestre, Adolfo García-Sastre, Viviana Simon, Lara Manganaro, Kevin Olivieri, Ana Fernandez-Sesma, Elisa de Castro
Publikováno v:
Journal of Virology. 89:9781-9790
The accessory HIV protein Vpu inhibits a number of cellular pathways that trigger host innate restriction mechanisms. HIV Vpu-mediated degradation of tetherin allows efficient particle release and hampers the activation of the NF-κB pathway thereby
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d490c4f98f814abf307ac587e40ef6e
https://doi.org/10.1128/jvi.01596-15
https://doi.org/10.1128/jvi.01596-15
Autor:
Laura J. Martins, Lars Pache, Peter Teriete, John M. Marlett, Ana M. Maestre, Viviana Simon, Miriam S. Dutra, Frederic D. Bushman, Young Hwang, Sumit K. Chanda, John A. T. Young, Lara Manganaro, Adam M. Spivak, Nicholas D. P. Cosford, Mitchell Vamos, Alberto Bosque, Ana Fernandez-Sesma, Vicente Planelles, Renate König, Jeffrey P. Murry
Publikováno v:
Cell Host & Microbe. 18:345-353
SummaryCombination antiretroviral therapy (ART) is able to suppress HIV-1 replication to undetectable levels. However, the persistence of latent viral reservoirs allows for a rebound of viral load upon cessation of therapy. Thus, therapeutic strategi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89096cc2f14b362f52511b3619760dd6
https://doi.org/10.1016/j.chom.2015.08.009
https://doi.org/10.1016/j.chom.2015.08.009