Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Ana M, Damas"'
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44992 (2012)
BACKGROUND: Defects in protein folding may lead to severe degenerative diseases characterized by the appearance of amyloid fibril deposits. Cytotoxicity in amyloidoses has been linked to poration of the cell membrane that may involve interactions wit
Externí odkaz:
https://doaj.org/article/cb48f66acfdd4148aba8ba37f096c1b7
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 11, Pp o2718-o2719 (2009)
In the title compound, C18H16O4, a monoprenylated xanthone, the xanthone skeleton exhibits an essentially planar conformation (r.m.s. deviation 0.0072 Å) and the isoprenyl side chain remains approximately in the mean plane of the xanthone unit, maki
Externí odkaz:
https://doaj.org/article/4e05de75b674402abd0e32097226529e
Autor:
Teresa Mairal, Joan Nieto, Marta Pinto, Maria Rosário Almeida, Luis Gales, Alfredo Ballesteros, José Barluenga, Juan J Pérez, Jesús T Vázquez, Nuria B Centeno, Maria Joao Saraiva, Ana M Damas, Antoni Planas, Gemma Arsequell, Gregorio Valencia
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4124 (2009)
The thyroid hormone and retinol transporter protein known as transthyretin (TTR) is in the origin of one of the 20 or so known amyloid diseases. TTR self assembles as a homotetramer leaving a central hydrophobic channel with two symmetrical binding s
Externí odkaz:
https://doaj.org/article/69a1e8debb4b437a809014b9a0c39525
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1998 (2008)
BACKGROUND: Vapor diffusion is the most widely used technique for protein crystallization and the rate of water evaporation plays a key role on the quality of the crystals. Attempts have been made in the past to solve the mass transfer problem govern
Externí odkaz:
https://doaj.org/article/dd8fb78c64f94dce8b8c2006fc4341b2
Autor:
Ana M. Damas, Fernando Rocha, Rosa Crespo, Pablo Taboada, Eva Villar-Alvarez, Pedro M. Martins
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The study of drug candidates for the treatment of amyloidosis and neurodegenerative diseases frequently involves in vitro measurements of amyloid fibril formation. Macromolecular crowding and off-pathway aggregation (OPA) are, by different reasons, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd153391a6404108ebc80c04d1ceec6
https://pubmed.ncbi.nlm.nih.gov/28221799
https://pubmed.ncbi.nlm.nih.gov/28221799
Autor:
Pedro M. Martins, Fernando Rocha, Cecília Ferreira, Ana M. Damas, Silvia Barbosa, Pablo Taboada
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
High supersaturation levels are a necessary but insufficient condition for the crystallization of purified proteins. Unlike most small molecules, proteins can take diverse aggregation pathways that make the outcome of crystallization assays quite unp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55c2baa757cbbbc808b235353ab0c60
https://hdl.handle.net/10216/106257
https://hdl.handle.net/10216/106257
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The aim of this work was to investigate the possibility ofproducing microparticles containing b-galactosidase, using a modified chitosan (water soluble) as encapsulating agent. b-galactosidasemicroparticles were prepared by a spray-drying method and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989801637fa44cbcbc99197ce1f4128c
https://doi.org/10.1080/07373937.2014.909843
https://doi.org/10.1080/07373937.2014.909843
Publikováno v:
Journal of molecular recognition : JMR. 30(3)
Toxicity in amyloidogenic protein misfolding disorders is thought to involve intermediate states of aggregation associated with the formation of amyloid fibrils. Despite their relevance, the heterogeneity and transience of these oligomers have placed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11acda4082075b416c1c90ea2f03122c
https://pubmed.ncbi.nlm.nih.gov/27808434
https://pubmed.ncbi.nlm.nih.gov/27808434
Autor:
Fernando Rocha, Rosa Crespo, Pedro M. Martins, Ana M. Damas, Pablo Taboada, Eva Villar-Alvarez
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Some of the most prevalent neurodegenerative diseases are characterized by the accumulation of amyloid fibrils in organs and tissues. Although the pathogenic role of these fibrils has not been completely established, increasing evidence suggests off-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c8ca612bb8474be604d9ee0d45d16f2
https://hdl.handle.net/10216/104177
https://hdl.handle.net/10216/104177
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Major discoveries in structural biology depend on obtaining well-diffracting macromolecular crystals. This necessity has motivated many fundamental studies on protein crystallization using lysozyme as a model system. In the present contribution, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7f3eea71460433137540e22faacbb0
https://hdl.handle.net/10216/103255
https://hdl.handle.net/10216/103255