Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ana Lucia Relo"'
Autor:
Wilfried Hornberger, Achim Moeller, Yanbin Lao, Kennan C. Marsh, Karla Drescher, Wicke Karsten, Andreas Kling, Ana Lucia Relo, Volker Nimmrich, Charles W. Hutchins, Katja Jantos, Helmut Mack
Publikováno v:
Journal of Medicinal Chemistry. 60:7123-7138
Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to th
Publikováno v:
Trends in Pharmacological Sciences. 37:364-378
In neuropsychiatric drug development, the rate of successful translation of preclinical to clinical efficacy has been disappointingly low. Tolerance, defined as a loss of efficacy with repeated drug exposure, is rarely addressed as a potential source
Autor:
Anil Vasudevan, Ana Lucia Relo, Irini Akritopoulou-Zanze, Hongyu Zhao, Mario Mezler, Carolin Hoft, Willi Amberg, Frauke Pohlki, Ying Wang, Yi-Yin Ku, Justin D. Dietrich, Michael Ochse, Yanbin Lao, Huan-Qiu Li, Steven M. Hannick, Jason T. Brewer, Berthold Behl, Jens Sydor, Udo Lange, Wilfried Hornberger
Publikováno v:
Journal of medicinal chemistry. 61(17)
The glycine transporter 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. Herein, we report the synthesis and biological evaluation of aminotetralines and aminochromanes as novel classes of competitive GlyT1 inhibitors.
Autor:
Udo Lange, Yanbin Lao, Wilfried Hornberger, Frauke Pohlki, Jens Sydor, Mario Mezler, Jason T. Brewer, Stevan W. Djuric, Berthold Behl, Irini Akritopoulou-Zanze, Justin D. Dietrich, Ana Lucia Relo, Hongyu Zhao, Carolin Hoft, Huan-Qiu Li, Ying Wang, Anil Vasudevan, Willi Amberg
Publikováno v:
Journal of medicinal chemistry. 61(17)
The development of glycine transporter 1 (GlyT1) inhibitors may offer putative treatments for schizophrenia and other disorders associated with hypofunction of the glutaminergic N-methyl-d-aspartate (NMDA) receptor. Herein, we describe the synthesis