Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ana Luísa Simplício"'
Autor:
Ricardo A Gomes, Conceição Almeida, Catarina Correia, Ana Guerreiro, Ana Luísa Simplício, Isabel A Abreu, Patrícia Gomes Alves
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219156 (2019)
The biopharmaceutical industry is growing at a fast pace, making nowadays 20% of the pharma market. Within this market, therapeutic monoclonal antibodies (mAbs) are the dominant product class. With the patent expirations, biosimilars and, perhaps mor
Externí odkaz:
https://doaj.org/article/be5a1cf7694e437bb905ff9090862a06
Publikováno v:
Saúde & Tecnologia, Vol 0, Iss 2, Pp 38-44 (2014)
The goal of this research project was the optimization of a method for simultaneously screen the dissolution rate and the permeability of drug formulations across Polyvinylidene Fluoride membranes, using a bilateral flow cell. Initially, the effect o
Externí odkaz:
https://doaj.org/article/77949e145a6442cfbc88aa517b1c6fa3
Publikováno v:
Saúde & Tecnologia, Iss 02 (2008)
Englobado na temática do desenvolvimento de métodos in vitro para avaliação da biodisponibilidade de fármacos, este trabalho de investigação teve como objectivo a optimização de um método para avaliar em simultâneo a dissolução e permeab
Externí odkaz:
https://doaj.org/article/d116fba067224dd4bcf5ad46731a4059
Autor:
Rute Castro, Tiago M. Bandeiras, Hélio A. Tomás, Ana Luísa Simplício, Ana S. Coroadinha, Júlia Costa, Márcia Alves, Joana Lamego
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 105-110 (2016)
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports
Human carboxylesterase 2 (hCES2) is a glycoprotein involved in the metabolism of drugs and several environmental xenobiotics, whose crystallization has been proved to be a challenging task. This limitation could partly be due to glycosylation heterog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1942cf1edf8925f4aa741db70b44700b
https://doi.org/10.1016/j.bbrep.2015.11.018
https://doi.org/10.1016/j.bbrep.2015.11.018
Autor:
Joana Poejo, Catarina M.M. Duarte, Ana Luísa Simplício, Ana A. Matias, Maria Rosário Bronze, Liliana Rodrigues, Inês Silva, Ana Teresa Serra
Publikováno v:
RSC Advances. 6:30905-30918
In this work, pressurized fluid extraction was explored to recover isothiocyanates (ITCs) and phenolic compounds from watercress. Pretreatment of the raw material was studied, using different conditions of temperature (25 °C; 35 °C), pressure (Patm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27d309dc2ebea842823bc1d57f2814c3
https://doi.org/10.1039/c5ra28068k
https://doi.org/10.1039/c5ra28068k
Publikováno v:
Synthesis. 47:3009-3012
An improved synthetic route to (3R,5S,1′S)-5-{1′-[(tert-butyloxycarbonyl)amino]-3′-methylbutyl}-3-methyldihydrofuran-2(3H)-one, a lactone precursor of the Leu-Ala (2R,4S,5S) hydroxyethylene isostere found in many peptidomimetic aspartyl prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b28aa91bec3614c1c0265a0985e7130
https://doi.org/10.1055/s-0034-1381036
https://doi.org/10.1055/s-0034-1381036
Autor:
Ana Luísa Simplício, Adelaide Fernandes, M. Rita Ventura, Olga Iranzo, Christopher D. Maycock, Helena Coelho, João Rocha, Helder Vila-Real
Publikováno v:
Journal of Medicinal Chemistry. 58:5408-5418
Alzheimer's disease is a grave social problem in an aging population. A major problem is the passage of drugs through the blood-brain barrier. This work tests the hypothesis that the conjugation of peptidomimetic β-secretase inhibitors with a fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676645b85df1d62b18c34d2b9e0a8850
https://doi.org/10.1021/acs.jmedchem.5b00658
https://doi.org/10.1021/acs.jmedchem.5b00658
Autor:
Catarina Correia, Ricardo Gomes, Conceição Almeida, Ana Guerreiro, Ana Luísa Simplício, Isabel A. Abreu, Patrícia Gomes Alves
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0219156 (2019)
PLoS ONE, Vol 14, Iss 7, p e0219156 (2019)
The biopharmaceutical industry is growing at a fast pace, making nowadays 20% of the pharma market. Within this market, therapeutic monoclonal antibodies (mAbs) are the dominant product class. With the patent expirations, biosimilars and, perhaps mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22992dcb97c38210c0d22933729bb838
https://doi.org/10.1371/journal.pone.0219156
https://doi.org/10.1371/journal.pone.0219156
Autor:
Helder Vila-Real, Luisa Beirão da Costa, Ana P. C. Almeida, Ana Teresa Serra, Soraya Rodríguez-Rojo, Catarina M.M. Duarte, Ana Luísa Simplício, Ivone Delgadilho, Sara Beirão da Costa, I.D. Nogueira
Publikováno v:
Innovative Food Science & Emerging Technologies. 20:140-145
Oregano (Origanum vulgare) essential oil (EO), besides its flavoring characteristics, is well known for its antioxidant, antimicrobial and anti-inflammatory properties, which make it a good alternative as food preservative from natural origin. Furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5f0da338b1d6ed56e7bc57704b0e86
https://doi.org/10.1016/j.ifset.2013.07.009
https://doi.org/10.1016/j.ifset.2013.07.009
Autor:
D. Deodato, I.D. Nogueira, Soraya Rodríguez-Rojo, Marta Requejo Fraile, Catarina M.M. Duarte, ÿ. Martín, Ana Luísa Simplício, María José Cocero
Publikováno v:
The Journal of Supercritical Fluids. 81:226-235
The formulation of S-(+)-ibuprofen as a model water-insoluble drug in different carrier materials (poloxamers, gelucire and glyceryl monostearate, GMS) by Particles from Gas Saturated Solutions (PGSS) technique has been studied. Porous, spherical par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aebbb06872b9bcd7c96daf161ef03e88
https://doi.org/10.1016/j.supflu.2013.06.010
https://doi.org/10.1016/j.supflu.2013.06.010