Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ana Leticia Maragno"'
Autor:
Ana Leticia Maragno, Martine Pironin, Hélène Alcalde, Xiuli Cong, Klaus-Peter Knobeloch, Frederic Tangy, Dong-Er Zhang, Jacques Ghysdael, Christine Tran Quang
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26068 (2011)
Activation of erythropoietin receptor allows erythroblasts to generate erythrocytes. In a search for genes that are up-regulated during this differentiation process, we have identified ISG15 as being induced during late erythroid differentiation. ISG
Externí odkaz:
https://doaj.org/article/9c01e5d590c24c1d92496e5dc622cded
Autor:
I-Jen Chen, Proszenyák Ágnes, Zoltán B. Szabó, Levente Ondi, Csékei Márton, Olivier Geneste, Szabolcs Sipos, Allan E. Surgenor, Frédéric Colland, C. Pedder, Maïa Chanrion, Balázs Bálint, Ana-Leticia Maragno, Roderick E. Hubbard, Szlávik Zoltán, Pawel Dokurno, András Kotschy, James B. Murray, James R. Davidson
Publikováno v:
ACS Omega, Vol 6, Iss 34, Pp 22073-22102 (2021)
ACS Omega
ACS Omega
Following the identification of thieno[2,3-d]pyrimidine-based selective and potent inhibitors of MCL-1, we explored the effect of core swapping at different levels of advancement. During hit-to-lead optimization, X-ray-guided S-N replacement in the c
Autor:
Ana-Leticia Maragno, Attila Paczal, András Kotschy, Didier Demarles, James Edward Paul Davidson, Szlávik Zoltán, Allan E. Surgenor, Gaëtane Le Toumelin-Braizat, James Murray, Proszenyák Ágnes, Frédéric Colland, Gabor Radics, Szabolcs Sipos, Olivier Geneste, Balázs Bálint, Csékei Márton, Zoltán B. Szabó, Pawel Dokurno, Audrey Claperon, Anne-Marie Girard, Chen I-Jen, Alain Bruno, Gaëlle Lysiak-Auvity, Roderick E. Hubbard, Maïa Chanrion, Zoe Daniels
Publikováno v:
Journal of medicinal chemistry. 63(22)
Myeloid cell leukemia 1 (Mcl-1) has emerged as an attractive target for cancer therapy. It is an antiapoptotic member of the Bcl-2 family of proteins, whose upregulation in human cancers is associated with high tumor grade, poor survival, and resista
Autor:
Melissa J. Davis, Shaun Fleming, Andrew H. Wei, Donia M Moujalled, Veronique Litalien, Laurence Kraus-Berthier, Charles G. Mullighan, Ana-Leticia Maragno, Soroor Hediyeh-Zadeh, Ashley P. Ng, Lorna Rasmussen, Guillaume Lessene, Sébastien Banquet, Paul G Ekert, Olivier Geneste, Diane T Hanna, Giovanna Pomilio, David C.S. Huang, Christine A White, Andrew W. Roberts, Marie Schoumacher, Ray Bartolo, Maïa Chanrion, Lauren M Brown, Angela Georgiou, Seong Lin Khaw
Publikováno v:
Blood Adv
Improving survival outcomes in adult B-cell acute lymphoblastic leukemia (B-ALL) remains a clinical challenge. Relapsed disease has a poor prognosis despite the use of tyrosine kinase inhibitors (TKIs) for Philadelphia chromosome positive (Ph+ ALL) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e036a8f464807723f471eb56cdde76c
https://europepmc.org/articles/PMC7322969/
https://europepmc.org/articles/PMC7322969/
Autor:
Lan Zhang, Y. Wang, Jessica M. Salmon, Corina Ghiurau, Andrew H. Wei, David C.S. Huang, Donia M Moujalled, Audrey Claperon, Olivier Geneste, Sarah MacRaild, Ping Lan, Guillaume Lessene, David J. Segal, Ana Leticia Maragno, Frédéric Colland, Tse-Chieh Teh, Laurence Kraus-Berthier, Adrien Zichi, Francesca Rocchetti, Giovanna Pomilio, Andrew W. Roberts, Adam Ivey, Ing Soo Tiong, Erick Morris, Maïa Chanrion, Ensar Halilovic, Sewa Rijal
Publikováno v:
Leukemia
Improving outcomes in acute myeloid leukemia (AML) remains a major clinical challenge. Overexpression of pro-survival BCL-2 family members rendering transformed cells resistant to cytotoxic drugs is a common theme in cancer. Targeting BCL-2 with the
Autor:
Chong Chyn Chua, Piers Blombery, Giovanna Pomilio, Guillaume Lessene, David C.S. Huang, Sébastien Banquet, Sarah MacRaild, Fiona C. Brown, Marco J Herold, Maïa Chanrion, Andrew W. Roberts, Olivier Geneste, Marie Schoumacher, Natasha S Anstee, Veronique Litalien, Thomas Morley, Ella R. Thompson, Andrew H. Wei, Ana-Leticia Maragno, Donia M Moujalled
Publikováno v:
Blood. 136:7-8
Background: Recent randomized trials have demonstrated improvements in overall survival (OS) for the BCL-2 inhibitor venetoclax (VEN) in combination with azacitidine and low dose cytarabine in older unfit patients with AML. Pre-clinical studies ident
Autor:
James A. H. Murray, Fabien Melchiore, Natalia Matassova, C. Pedder, Frédéric Colland, Catherine Chang, Levente Ondi, Laura C. A. Galbraith, Pawel Dokurno, Andrew W. Roberts, Chris D. Riffkin, Nolwen Guigal-Stephan, Proszenyák Ágnes, John A. Hickman, Andreas Strasser, Aurélie Studeny, Gaëlle Lysiak-Auvity, András Kotschy, Gemma L. Kelly, Fabienne Gravé, Ghislaine Guasconi, Brandon J. Aubrey, Attila Paczal, Julia Smith, Szlávik Zoltán, Gabor Radics, Brian Lockhart, David C.S. Huang, Maïa Chanrion, Gaëtane Le Toumelin-Braizat, Jia-Nan Gong, Nicolas Cauquil, Szabolcs Sipos, Alan P. Robertson, Giovanna Pomilio, James Edward Paul Davidson, Zoltán B. Szabó, Ana Leticia Maragno, Chris Graham, Marco J Herold, Gábor Blasko, Margs S. Brennan, Anne-Marie Girard, Allan E. Surgenor, Andrew H. Wei, Csékei Márton, Olivier Geneste, Chen I-Jen, Alain Bruno, David J. Segal, Guillaume Lessene, Balázs Bálint, Donia M Moujalled
Publikováno v:
Nature. 538:477-482
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are a
Autor:
Seong Lin Khaw, David C.S. Huang, Andrew H. Wei, Donia M Moujalled, Giovanna Pomillio, Ashley P. Ng, Laurence Kraus-Berthier, Olivier Geneste, Veronique Litalien, Andrew W. Roberts, Ana-Leticia Maragno, Shaun Fleming, Guillaume Lessene, Diane T Hanna, Paul G Ekert, Marie Chanrion
Publikováno v:
Experimental Hematology. 76:S79-S80
Precursor-B acute lymphoblastic leukemia (B-ALL) is an aggressive hematological malignancy. Relapsed disease has a poor prognosis despite improved outcomes with tyrosine kinase inhibitors (TKIs) and immunotherapeutic approaches such as CAR-T cells. T
Autor:
Maïa Chanrion, Antonin Serrano, Delphine Merino, Guillaume Lessene, Najoua Lalaoui, Göknur Giner, Jia-Nan Gong, Jane E. Visvader, Grant Dewson, François Vaillant, James R. Whittle, David C.S. Huang, Emilie Schneider, Geoffrey J. Lindeman, Ana Leticia Maragno, Xiang Li, Kevin H. Liu, Bhupinder Pal, Gordon K. Smyth, Marco J Herold, David J. Segal, Olivier Geneste, Julius Gräsel
Publikováno v:
Science Translational Medicine. 9
The development of BH3 mimetics, which antagonize prosurvival proteins of the BCL-2 family, represents a potential breakthrough in cancer therapy. Targeting the prosurvival member MCL-1 has been an area of intense interest because it is frequently de
Autor:
Audrey Clapéron, Balázs Bálint, Chen I-Jen, Alain Bruno, Attila Paczal, Szlávik Zoltán, Zoltán B. Szabó, Ensar Halilovic, Heiko Maacke, Alix Derreal, James Edward Paul Davidson, Maïa Chanrion, Ana Leticia Maragno, Szabolcs Sipos, Fabienne Grave, Olivier Geneste, James Murray, Proszenyák Ágnes, Youzhen Wang, Natalia Matassova, Pawel Dokurno, Allan E. Surgenor, Csékei Márton, Prakash Mistry, András Kotschy, Gaëtane Le Toumelin-Braizat, Erick Morris, Frédéric Colland, Anne-Marie Girard, Gaëlle Lysiak-Auvity
Publikováno v:
Cancer Research. 79:4482-4482
Mcl-1 is highly expressed in a variety of human cancers (including those of hematopoietic and lymphoid origin) and is exploited by cancer cells to evade cell death and to develop resistance to diverse chemotherapeutic agents. We disclose, for the fir