The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility

Autor: Patience Sanderson, Thomas Mandel Clausen, Ana L. Saldanha, Yang Mao, Alejandro Gomez Toledo, Ali Salanti, Franklin E. Leach rd, Francesco Gatto, I. Jonathan Amster, Swati Choudhary, Charlotte B Spliid, Ismail Gögenur, Jeffrey D. Esko, Thor G. Theander, Tobias Gustavsson, Rasmus Peuliche Vogelsang

Publikováno v: Spliid, C B, Toledo, A G, Sanderson, P, Mao, Y, Gatto, F, Gustavsson, T, Choudhary, S, Saldanha, A L, Vogelsang, R P, Gögenur, I, Theander, T G, Leach, F E, Amster, I J, Esko, J D, Salanti, A & Clausen, T M 2021, ' The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility ', The Journal of Biological Chemistry, vol. 297, no. 6, 101391 . https://doi.org/10.1016/j.jbc.2021.101391
J Biol Chem

Placental malaria infection is mediated by the binding of the malarial VAR2CSA protein to the placental glycosaminoglycan, chondroitin sulfate. Recombinant sub-fragments of VAR2CSA (rVAR2) have also been shown to bind specifically and with high affin

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https://curis.ku.dk/ws/files/287629835/1_s2.0_S0021925821011972_main.pdf