Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids

Autor: Marc Oeller, Ryan J. D. Kang, Hannah L. Bolt, Ana L. Gomes dos Santos, Annika Langborg Weinmann, Antonios Nikitidis, Pavol Zlatoidsky, Wu Su, Werngard Czechtizky, Leonardo De Maria, Pietro Sormanni, Michele Vendruscolo

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Non-natural amino acids are increasingly used as building blocks in the development of peptide-based drugs as they expand the available chemical space to tailor function, half-life and other key properties. However, while the chemical space

Externí odkaz: https://doaj.org/article/0caac934400240c99334cfb366d281f4

Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays

Autor: Essyrose Mathew, Giulia Pitzanti, Ana L. Gomes dos Santos, Dimitrios A. Lamprou

Publikováno v: Pharmaceutics, Vol 13, Iss 11, p 1837 (2021)

3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However,

Externí odkaz: https://doaj.org/article/3ef3b84e0b4d4261806acab18b34d402

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Autor: Esmenia C. Rocha, Vitor H. Nascimento, Pedro S. Peixoto, Thomas A. Mellan, Lucas A M Franco, Henrique Hoeltgebaum, Michaela A. C. Vollmer, Oliver Ratmann, Leonardo José Tadeu de Araújo, Nuno R. Faria, Philippe Lemey, Raphael Sonabend, Myuki A E Crispim, Nelson Gaburo, Charles Whittaker, Joice do P. Silva, Ruben J.G. Hulswit, Ricardo P Schnekenberg, Cecilia da C. Camilo, Mariana C. Pinho, Darlan da Silva Candido, Neil M. Ferguson, Helem M. dos Santos, Ester Cerdeira Sabino, Patrick G T Walker, Hannah M. Schlüter, Carlos A. Prete, Thais M. Coletti, Erika R. Manuli, Oliver G. Pybus, Samir Bhatt, Alessandro C. S. Ferreira, Mariana S. Ramundo, Danielle A G Zauli, Aline B. de Lima, Jaqueline Goes de Jesus, Iwona Hawryluk, Frederico S V Malta, Marc A. Suchard, Leandro Marques de Souza, Seth Flaxman, Moritz U. G. Kraemer, James A. Hay, Valentina S. Del Caro, Rosinaldo M. F. Filho, Axel Gandy, Pamela S Andrade, Andrew Rambaut, Ingra Morales Claro, Ana L. P. dos Santos, Christopher Dye, José Luiz Proença-Módena, Swapnil Mishra, Daniel J Laydon, William Marciel de Souza, Renato Santana Aguiar, Xenia Miscouridou, Camila A. M. Silva, Maria S. Vidal, John T. McCrone, Maria Perpétuo Socorro Sampaio Carvalho, Nicholas J. Loman, Giulia M. Ferreira, Bruce Walker Nelson, Chieh-Hsi Wu, Thomas A. Bowden, Melodie Monod, Helen Coupland, Rafael Henrique Moraes Pereira, Flavia C. S. Sales, Sergei L Kosakovsky Pond, Nelson Abrahim Fraiji

Publikováno v: Faria, N R, Mellan, T A, Whittaker, C, Claro, I M, Candido, D D S, Mishra, S, Crispim, M A E, Sales, F C, Hawryluk, I, McCrone, J T, Hulswit, R J G, Franco, L A M, Ramundo, M S, de Jesus, J G, Andrade, P S, Coletti, T M, Ferreira, G M, Silva, C A M, Manuli, E R, Pereira, R H M, Peixoto, P S, Kraemer, M U, Gaburo, N, Camilo, C D C, Hoeltgebaum, H, Souza, W M, Rocha, E C, de Souza, L M, de Pinho, M C, Araujo, L J T, Malta, F S, de Lima, A B, Silva, J D P, Zauli, D A G, Ferreira, A C D S, Schnekenberg, R P, Laydon, D J, Walker, P G T, Schlueter, H M, dos Santos, A L P, Vidal, M S, Del Caro, V S, Filho, R M F, dos Santos, H M, Aguiar, R S, Proenca-Modena, J L P, Nelson, B, Hay, J A, Monod, M, Miscouridou, X, Coupland, H, Sonabend, R, Vollmer, M, Gandy, A, Prete, C A, Nascimento, V H, Suchard, M A, Bowden, T A, Pond, S L K, Wu, C-H, Ratmann, O, Ferguson, N M, Dye, C, Loman, N J, Lemey, P, Rambaut, A, Fraiji, N A, Carvalho, M D P S S, Pybus, O G, Flaxman, S, Bhatt, S & Sabino, E C 2021, ' Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil ', Science, vol. 372, no. 6544, 2644, pp. 815-821 . https://doi.org/10.1126/science.abh2644
Science (New York, N.Y.), vol 372, iss 6544
Science
Faria, N R, Mellan, T A, Whittaker, C, Claro, I M, Candido, D D S, Mishra, S, Crispim, M A E, Sales, F C S, Hawryluk, I, McCrone, J T, Hulswit, R J G, Franco, L A M, Ramundo, M S, de Jesus, J G, Andrade, P S, Coletti, T M, Ferreira, G M, Silva, C A M, Manuli, E R, Pereira, R H M, Peixoto, P S, Kraemer, M U G, Gaburo, N, Camilo, C D C, Hoeltgebaum, H, Souza, W M, Rocha, E C, de Souza, L M, de Pinho, M C, Araujo, L J T, Malta, F S V, de Lima, A B, Silva, J D P, Zauli, D A G, Ferreira, A C D S, Schnekenberg, R P, Laydon, D J, Walker, P G T, Schlüter, H M, Dos Santos, A L P, Vidal, M S, Del Caro, V S, Filho, R M F, Dos Santos, H M, Aguiar, R S, Proença-Modena, J L, Nelson, B, Hay, J A, Monod, M, Miscouridou, X, Coupland, H, Sonabend, R, Vollmer, M, Gandy, A, Prete, C A, Nascimento, V H, Suchard, M A, Bowden, T A, Pond, S L K, Wu, C-H, Ratmann, O, Ferguson, N M, Dye, C, Loman, N J, Lemey, P, Rambaut, A, Fraiji, N A, Carvalho, M D P S S, Pybus, O G, Flaxman, S, Bhatt, S & Sabino, E C 2021, ' Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil ', Science . https://doi.org/10.1126/science.abh2644
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Unmitigated spread in Brazil Despite an extensive network of primary care availability, Brazil has suffered profoundly during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Using daily data from state health offices, Castr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea70b892f31041eeeac7bf73de7de47
https://doi.org/10.1126/science.abh2644