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pro vyhledávání: '"Ana L. Ayub"'
Autor:
Ana L. Ayub, Leisl M. Packer, Nicholas K. Hayward, Sandra Pavey, Helen Rizos, Glen M. Boyle, Mitchell S. Stark
Publikováno v:
International Journal of Cancer. 121:784-790
p14ARF is inactivated by deletions/mutations in many cancer types and can suppress cell growth by both p53-dependent and p53-independent mechanisms. To identify novel downstream effectors of p14ARF, we used gene expression profiling as a primary scre
Publikováno v:
International Journal of Cancer. 117:569-573
Melanoma-associated germline mutations affecting the tumor suppressor and cyclin-dependent kinase (CDK) inhibitor, CDKN2A/p16INK4a, have been identified in over 100 melanoma-prone families worldwide. To predict the melanoma risk for carriers of speci
Autor:
Heather A. McKenzie, Sarah Woodruff, Richard F. Kefford, Lyndee L. Scurr, Helen Rizos, Ana L. Ayub, Therese M. Becker, Joachim Stahl
Publikováno v:
The Journal of biological chemistry. 281(49)
Alterations in the p14(ARF) tumor suppressor are frequent in many human cancers and are associated with susceptibility to melanoma, pancreatic cancer, and nervous system tumors. In addition to its p53-regulatory functions, p14(ARF) has been shown to