Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ana L. Alvarez-Cabrera"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Human APOBEC3 (A3) cytidine deaminases are antiviral factors that are particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity factor (Vif) to target specific human A3s for proteasomal degradation. Vif re
Externí odkaz:
https://doaj.org/article/ccefc56b49dd489c8567077a2c3cd2f0
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mammalian reovirus (MRV) is a double-stranded RNA (dsRNA) virus that affects the gastrointestinal and respiratory tracts. Here, the authors present the 3.3 Å cryo-EM asymmetric reconstruction of transcribing MRV that reveals the organization of the
Externí odkaz:
https://doaj.org/article/22f352c3fd614f9fbae6f2f2d0326311
Autor:
Yibo Zhang, Wei Liu, Zihang Li, Vinay Kumar, Ana L. Alvarez-Cabrera, Emily C. Leibovitch, Yanxiang Cui, Ye Mei, Guo-Qiang Bi, Steve Jacobson, Z. Hong Zhou
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Human Herpesvirus 6B (HHV-6) can cause fever, diarrhea and roseola rash. Here the authors present a cryoEM approach to image crude, minimally purified virus samples and employ it to determine the atomic structures of HHV-6B capsid and capsid-associat
Externí odkaz:
https://doaj.org/article/1062cc7672534646a1f32c8bd2fcbf60
Autor:
Fumiaki Ito, Ana L. Alvarez-Cabrera, Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z. Hong Zhou, Xiaojiang S. Chen
Publikováno v:
Science advances. 9(1)
Human APOBEC3G (A3G) is a virus restriction factor that inhibits HIV-1 replication and triggers lethal hypermutation on viral reverse transcripts. HIV-1 viral infectivity factor (Vif) breaches this host A3G immunity by hijacking a cellular E3 ubiquit
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mammalian reovirus (MRV) is the prototypical member of genus Orthoreovirus of family Reoviridae. However, lacking high-resolution structures of its RNA polymerase cofactor μ2 and infectious particle, limits understanding of molecular interactions am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d71c2ad7784e935ecf57879b780a3ef
https://escholarship.org/uc/item/3wj042f2
https://escholarship.org/uc/item/3wj042f2
Autor:
Ana L. Alvarez-Cabrera, Ye Mei, Yanxiang Cui, Steve Jacobson, Yibo Zhang, Guo-Qiang Bi, Vinay Kumar, Wei Liu, Zihang Li, Z. Hong Zhou, Emily C. Leibovitch
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Human herpesvirus 6B (HHV-6B) belongs to the β-herpesvirus subfamily of the Herpesviridae. To understand capsid assembly and capsid-tegument interactions, here we report atomic structures of HHV-6B capsid and capsid-associated tegument complex (CATC
Publikováno v:
Virology Journal, Vol 14, Iss 1, Pp 1-12 (2017)
Virology Journal
Virology Journal
Background Simian Virus 40 (SV40) Large Tumor Antigen (LT) is an essential enzyme that plays a vital role in viral DNA replication in mammalian cells. As a replicative helicase and initiator, LT assembles as a double-hexamer at the SV40 origin to ini
Autor:
Sandra Delgado, David Gil-Carton, Carlos Oscar S. Sorzano, Guillermo Montoya, Tang K. Tang, Gulnahar B. Mortuza, Ana L. Alvarez-Cabrera, José María Carazo
Publikováno v:
Frontiers in Molecular Biosciences
Digital.CSIC. Repositorio Institucional del CSIC
instname
Alvarez-Cabrera, A L, Delgado, S, Gil-Carton, D, Mortuza, G B, Montoya, G, Sorzano, C O S, Tang, T K & Carazo, J M 2017, ' Electron Microscopy Structural Insights into CPAP Oligomeric Behavior : A Plausible Assembly Process of a Supramolecular Scaffold of the Centrosome ', Frontiers in Molecular Biosciences, vol. 4, 17 . https://doi.org/10.3389/fmolb.2017.00017
Digital.CSIC. Repositorio Institucional del CSIC
instname
Alvarez-Cabrera, A L, Delgado, S, Gil-Carton, D, Mortuza, G B, Montoya, G, Sorzano, C O S, Tang, T K & Carazo, J M 2017, ' Electron Microscopy Structural Insights into CPAP Oligomeric Behavior : A Plausible Assembly Process of a Supramolecular Scaffold of the Centrosome ', Frontiers in Molecular Biosciences, vol. 4, 17 . https://doi.org/10.3389/fmolb.2017.00017
Centrosomal P4.1-associated protein (CPAP) is a cell cycle regulated protein fundamental for centrosome assembly and centriole elongation. In humans, the region between residues 897–1338 of CPAP mediates interactions with other proteins and include
StructMap: Elastic Distance Analysis of Electron Microscopy Maps for Studying Conformational Changes
Autor:
Ana L. Alvarez-Cabrera, Slavica Jonic, Carlos Oscar S. Sorzano, José María Carazo, Mohsen Kazemi
Publikováno v:
Biophysical Journal
Biophysical Journal, 2016, 110 (8), pp.1753-1765. ⟨10.1016/j.bpj.2016.03.019⟩
Biophysical Journal, Biophysical Society, 2016, 110 (8), pp.1753-1765. ⟨10.1016/j.bpj.2016.03.019⟩
Biophysical Journal, 2016, 110 (8), pp.1753-1765. ⟨10.1016/j.bpj.2016.03.019⟩
Biophysical Journal, Biophysical Society, 2016, 110 (8), pp.1753-1765. ⟨10.1016/j.bpj.2016.03.019⟩
International audience; Single-particle electron microscopy (EM) has been shown to be very powerful for studying structures and associated conformational changes of macromolecular complexes. In the context of analyzing conformational changes of compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ae312ab5d1398eb4b4c5ec2ed18272
https://europepmc.org/articles/PMC4850348/
https://europepmc.org/articles/PMC4850348/
Autor:
Roberto Marabini, Joaquín Otón, Vahid Abrishami, Ana L. Alvarez-Cabrera, J.M. de la Rosa-Trevín, Javier Vargas, José María Carazo, E. Sesmero, Carlos Oscar S. Sorzano
Publikováno v:
Journal of structural biology. 189(3)
Cryo Electron Microscopy is a powerful Structural Biology technique, allowing the elucidation of the three-dimensional structure of biological macromolecules. In particular, the structural study of purified macromolecules –often referred as Single