Leptin, Both Bad and Good Actor in Cancer

Autor: Carlos Jiménez-Cortegana, Ana López-Saavedra, Flora Sánchez-Jiménez, Antonio Pérez-Pérez, Jesús Castiñeiras, Juan A. Virizuela-Echaburu, Luis de la de la Cruz-Merino, Víctor Sánchez-Margalet

Publikováno v: Biomolecules, Vol 11, Iss 6, p 913 (2021)

Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in obesity. Leptin exerts many different actions on various tissues and systems, including cancer, and is considered as a linkage between metabolism and the imm

Externí odkaz: https://doaj.org/article/0fcbd0f39cc5438ab95f61dcf5678ae2

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

Autor: Andrés Cruz-García, Ana López-Saavedra, Pablo Huertas

Publikováno v: Cell Reports, Vol 9, Iss 2, Pp 451-459 (2014)

DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-prote

Externí odkaz: https://doaj.org/article/e14cb73f6e9a44a7b1a865002f8a757d

Multiple roles of the splicing complex SF3B in DNA end resection and homologous recombination

Autor: Pablo Huertas, Cristina Cepeda-García, Rosario Prados-Carvajal, Ana López-Saavedra, Sonia Jimeno

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The appropriate repair of DNA double strand breaks is critical for genome maintenance. Thus, several cellular pathways collaborate to orchestrate a coordinated response. These include the repair of the breaks, which could be achieved by different mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abaefda13cdca28bd09f3330e2ea426
https://doi.org/10.1016/j.dnarep.2018.04.003

A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

Autor: Fernando Mejías-Navarro, María Isabel Martínez-Macías, Pablo Huertas, Daniel Gómez-Cabello, Ana López-Saavedra, María S. Domínguez-Sánchez, Jiri Bartek, María Jesús Fernández-Ávila, Christoffel Dinant

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these pathways; in this study we to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbb6b0be1cb66fa03b6808ef58eaac4

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination

Autor: Felipe Cortés Ledesma, Yukihide Tomari, Stephen Philip Jackson, Pablo Huertas, Sandra Muñoz-Galván, Ana López Saavedra, Andres Aguilera

Publikováno v: Nucleic Acids Research
Nucleic Acids Research; Vol 41
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC

While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of double-strand break (DSB) repair is exerted at several steps, the key step is DNA end resection, which in Saccharomyces cerevisiae is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4753292d9e5578f3367b344fd5fa8c3a