Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ana Krhac Levacic"'
Autor:
Stephan Morys, Ana Krhac Levacic, Sarah Urnauer, Susanne Kempter, Sarah Kern, Joachim O. Rädler, Christine Spitzweg, Ulrich Lächelt, Ernst Wagner
Publikováno v:
Polymers, Vol 9, Iss 4, p 142 (2017)
Cationic polymers are promising components of the versatile platform of non-viral nucleic acid (NA) delivery agents. For a successful gene delivery system, these NA vehicles need to comprise several functionalities. This work focuses on the modificat
Externí odkaz:
https://doaj.org/article/bbf1c5316c414df0a45a167289f5833f
Autor:
Simone Berger, Judith Müller, Andrea Wegner, Ulrich Lächelt, Ana Krhac Levacic, Christian Dohmen, Carsten Rudolph, Ernst Wagner
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 339
Currently, messenger RNA (mRNA)-based lipid nanoparticle formulations revolutionize the clinical field. Cationic polymer-based complexes (polyplexes) represent an alternative compound class for mRNA delivery. After establishing branched polyethylenim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363093391316d98f1184c2dfc6d68ffd
https://pubmed.ncbi.nlm.nih.gov/34547258
https://pubmed.ncbi.nlm.nih.gov/34547258
Autor:
Elisa Hörterer, Ulrich Wilk, Yanfang Wang, Simone Berger, Teoman Benli-Hoppe, Ernst Wagner, Jie Luo, Özgür Öztürk, Ana Krhac Levacic
Publikováno v:
Biomacromolecules. 22(3)
When optimizing nanocarriers, structural motifs that are beneficial for the respective type of cargo need to be identified. Here, succinoyl tetraethylene pentamine (Stp)-based lipo-oligoaminoamides (OAAs) were optimized for the delivery of plasmid DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b8d4aab25632e79fbf22616435e31c
https://pubmed.ncbi.nlm.nih.gov/34854679
https://pubmed.ncbi.nlm.nih.gov/34854679
Autor:
Ulrich Lächelt, Don C. Lamb, Lun Peng, Ernst Wagner, Yi Lin, Ana Krhac Levacic, Miriam Höhn, Jasmin Kuhn, Nader Al Danaf
Publikováno v:
Bioconjugate Chemistry
The programmable endonuclease activity and simple usage of CRISPR/Cas9 have revolutionized the field of genome editing. The binding of single guide RNA (sgRNA) by the Cas9 protein results in the formation of negatively charged ribonucleoprotein (RNP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06f3862b8053531e208d08b82e80e9e
https://pubmed.ncbi.nlm.nih.gov/31967454
https://pubmed.ncbi.nlm.nih.gov/31967454
Autor:
Sarah Urnauer, Peter Bartenstein, Christian Zach, Christina Schug, Kathrin A Schmohl, Stephan Morys, Ana Krhac Levacic, Christine Spitzweg, Ernst Wagner, Janette Carlsen, Andrea M. Müller, Nathalie Schwenk
Publikováno v:
Molecular Therapy. 24:1395-1404
The sodium iodide symporter (NIS) as well-characterized theranostic gene represents an outstanding tool to target different cancer types allowing noninvasive imaging of functional NIS expression and therapeutic radioiodide application. Based on its o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cdb0c0cac391b29f618d85328716ee
https://doi.org/10.1038/mt.2016.95
https://doi.org/10.1038/mt.2016.95
Autor:
Eva Kessel, Linda Beckert, Ana Krhac Levacic, Libor Kostka, Hana Kostková, Tomáš Etrych, Ulrich Lächelt, Ernst Wagner
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 105:85-96
We report novel pH-reversibly surface-shielded polyplexes with enhanced gene transfer activity upon systemic administration. A four-arm-structured sequence-defined cationic oligomer KK[HK[(H-Sph-K)3HC]2]2 was designed and synthesized on solid-phase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9feab0be70970a9ae22d053af57fe5
https://doi.org/10.1016/j.ejpb.2016.05.019
https://doi.org/10.1016/j.ejpb.2016.05.019
Autor:
Petra Kos, Ulrich Lächelt, Frauke Martina Mickler, Dongsheng He, Markus Döblinger, Christoph Bräuchle, Ana Krhac Levacic, Ernst Wagner, Stephan Morys, Annika Herrmann
Publikováno v:
Nanoscale. 7:5350-5362
Overexpression of the hepatocyte growth factor receptor/c-Met proto oncogene on the surface of a variety of tumor cells gives an opportunity to specifically target cancerous tissues. Herein, we report the first use of c-Met as receptor for non-viral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688abfbbc75ec814fe192d32f980b8f1
https://doi.org/10.1039/c4nr06556e
https://doi.org/10.1039/c4nr06556e
Publikováno v:
Human gene therapy. 28(10)
Due to its minimal size and lack of bacterial backbone sequences, minicircle (MC) DNA presents a promising alternative to plasmid DNA (pDNA) for non-viral gene delivery in terms of biosafety and improved gene transfer. Here, luciferase pDNA (pCMV-luc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d99884f332d571367d428f832d7cc5
https://pubmed.ncbi.nlm.nih.gov/28826232
https://pubmed.ncbi.nlm.nih.gov/28826232
Publikováno v:
Bioscience Reports
Nucleic acid molecules are important therapeutic agents in the field of antisense oligonucleotide, RNA interference, and gene therapies. Since nucleic acids are not able to cross cell membranes and enter efficiently into cells on their own, the devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5cd2433fd73acd149e67edfa7edf57
https://pubmed.ncbi.nlm.nih.gov/28963371
https://pubmed.ncbi.nlm.nih.gov/28963371
Autor:
Nathalie Schwenk, Kathrin A Schmohl, Janette Carlsen, Christian Zach, Christine Spitzweg, Ernst Wagner, Ana Krhac Levacic, Andrea M. Müller, Stephan Morys, Sarah Urnauer, Peter Bartenstein, Christina Schug
Publikováno v:
Endocrine Abstracts.
The sodium iodide symporter (NIS) as well-characterized theranostic gene represents an outstanding tool to target different cancer types allowing noninvasive imaging of functional NIS expression and therapeutic radioiodide application. Based on its o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd2dcbda1229b5ef475f01824061be2
https://doi.org/10.1530/endoabs.41.ep1098
https://doi.org/10.1530/endoabs.41.ep1098