Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Ana Koperniku"'
1
Boosting the Discovery of Small Molecule Inhibitors of Glucose-6-Phosphate Dehydrogenase for the Treatment of Cancer, Infectious Diseases, and Inflammation
Autor: Ana Koperniku, Adriana A. Garcia, Daria Mochly-Rosen
Publikováno v: J Med Chem
We present an overview of small molecule glucose-6-phosphate dehydrogenase (G6PD) inhibitors that have potential for use in the treatment of cancer, infectious diseases, and inflammation. Both steroidal and non-steroidal inhibitors have been identifi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591b4cc8ca5584f1cb0cdfc19cf4f27d
https://doi.org/10.1021/acs.jmedchem.1c01577
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2
N-Silylamines in catalysis: synthesis and reactivity
Autor: Vani Verma, Ana Koperniku, Peter M. Edwards, Laurel L. Schafer
Publikováno v: Chemical Communications. 58:9174-9189
Efficient catalytic routes to prepare electronically and sterically distinct silylamine building blocks for the step-economic synthesis of amines and N-heterocycles.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a5c74c69983f7b6228889a8b60e9361
https://doi.org/10.1039/d2cc02915d
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3
Affordable IgY-based antiviral prophylaxis for resource-limited settings to address epidemic and pandemic risks
Autor: Carrie J Chen, Anna F Hudson, Allison S Jia, Caitlin R Kunchur, Andrew J Song, Edward Tran, Chris J Fisher, Davide Zanchi, Lucia Lee, Stephen Kargotich, Mary Romeo, Ana Koperniku, Ravinder D Pamnani, Daria Mochly-Rosen
Publikováno v: Journal of Global Health. 12
The COVID-19 pandemic caused by SARS-CoV-2 exposed a global problem, as highly effective vaccines are challenging to produce and distribute, particularly in regions with limited resources and funding. As an alternative, immunoglobulins produced in eg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4e9619dd166c5434a6fee4e8c702b1
https://doi.org/10.7189/jogh.12.05009
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4
Treatment Strategies for Glucose-6-Phosphate Dehydrogenase Deficiency: Past and Future Perspectives
Autor: Ana Koperniku, Daria Mochly-Rosen, Adriana A. Garcia, Julio C.B. Ferreira
Publikováno v: Trends Pharmacol Sci
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Glucose-6-phosphate dehydrogenase (G6PD) maintains redox balance in a variety of cell types and is essential for erythrocyte resistance to oxidative stress. G6PD deficiency, caused by mutations in the G6PD gene, is present in ~400 million people worl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564f99589113d9cbf006fcb27a4c83ce
https://europepmc.org/articles/PMC8448981/
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5
Zirconium Hydroaminoalkylation. An Alternative Disconnection for the Catalytic Synthesis of α-Arylated Primary Amines
Autor: Ana Koperniku, Paul J. Foth, Glenn M. Sammis, Laurel L. Schafer
Publikováno v: Journal of the American Chemical Society. 141:18944-18948
Primary amine products have been prepared using zirconium-catalyzed hydroaminoalkylation of alkenes with N-silylated benzylamine substrates. Catalysis using commercially available Zr(NMe2)4 affords an alternative disconnection to access α-arylated p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a351eb46a8b03b8d163685efc1f87343
https://doi.org/10.1021/jacs.9b10465
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6
The Reaction of N-Trimethylsilyl-Substituted Heteroarylamines with Esters and Thioesters: An Efficient Protocol To Access Diheteroarylamides
Autor: Maryam Zamiri, Ana Koperniku, David S. Grierson
Publikováno v: Synthesis. 51:1779-1790
The S-benzyl thioester and methyl ester derivatives of a representative 4-pyridinone-based carboxylic acid were sufficiently activated to react efficiently in amide coupling reactions with the amide anion generated in situ from the N-trimethylsilyl d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62e6e6a303ba0086eb5e8bdda3167ebe
https://doi.org/10.1055/s-0037-1611435
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7
Zirconium Catalyzed Hydroaminoalkylation for the Synthesis of α-Arylated Amines and N-Heterocycles
Autor: Laurel L. Schafer, Ana Koperniku
Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 27(20)
The zirconium catalyzed hydroaminoalkylation of alkenes with N-aryl- and sterically demanding N-alkyl-α-arylated secondary amines by using commercially available Zr(NMe2 )4 is reported. N-phenyl- and N-isopropylbenzylamine are used as amine substrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::147aa729effd8acf2ba2d3466f54d923
https://pubmed.ncbi.nlm.nih.gov/33427338
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8
A series of selective events
Autor: Ana Koperniku
Publikováno v: Nature Reviews Chemistry. 5:674-675
Three unprecedented selective bioconjugation methods for serine, methionine and lysine have been realized. Specifically, chemoselectivity for serine, site-selectivity for methionine and site-specificity for lysine were achieved.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67db43fa3ff1dd07a80fcd2cb85b240e
https://doi.org/10.1038/s41570-021-00317-x
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10
ChemInform Abstract: Mono- and Difluorination of Benz~ylic Carbon Atoms
Autor: Hongqiang Liu, Ana Koperniku, Paul B. Hurley
Publikováno v: ChemInform. 47
This microreview is divided into four parts: introduction, benzylic monofluorination, benzylic difluorination and summary. Each procedure (base-mediated, transition-metal-catalyzed, radical-initiated benzylic fluorination) is described for the cases
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20a03afe2b8f0deecb535ddf004c167e
https://doi.org/10.1002/chin.201615261
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