Crystal structure of thioredoxin 1 from Cryptococcus neoformans at 1.8 Å resolution shows unexpected plasticity of the loop preceding the catalytic site

Autor: Claudia Patricia Bravo-Chaucanés, Ana Karina Rodrigues Abadio, Érika Seki Kioshima, Maria Sueli Soares Felipe, João Alexandre Ribeiro Gonçalves Barbosa

Publikováno v: Biochemistry and Biophysics Reports, Vol 21, Iss , Pp - (2020)

An elevated prevalence of cryptococcal infection is a tendency in low-income countries and constitutes a global public health problem due to factors such as the limited efficacy of antifungal therapy and the AIDS/transplant immunocompromised patients

Externí odkaz: https://doaj.org/article/f835c3b624b74d3f928fda217ba18209

Identification of New Antifungal Compounds Targeting Thioredoxin Reductase of Paracoccidioides Genus.

Autor: Ana Karina Rodrigues Abadio, Erika Seki Kioshima, Vincent Leroux, Natalia Florêncio Martins, Bernard Maigret, Maria Sueli Soares Felipe

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142926 (2015)

The prevalence of invasive fungal infections worldwide has increased in the last decades. The development of specific drugs targeting pathogenic fungi without producing collateral damage to mammalian cells is a daunting pharmacological challenge. Ind

Externí odkaz: https://doaj.org/article/f8317d3c4fc14efc9a8540a74e040cae

Selection of potential anti-adhesion drugs by in silico approaches targeted to ALS3 from Candida albicans

Autor: Erika Seki Kioshima, Bernard Maigret, Maria Sueli Soares Felipe, Ana Karina Rodrigues Abadio, Cristiane Suemi Shinobu-Mesquita, Terezinha Inez Estivalet Svidzinski

Publikováno v: Biotechnology Letters
Biotechnology Letters, Springer Verlag, 2019, 41 (12), pp.1391-1401. ⟨10.1007/s10529-019-02747-6⟩
Biotechnology Letters, 2019, 41 (12), pp.1391-1401. ⟨10.1007/s10529-019-02747-6⟩

To select potential ligands of ALS3 for drug development with anti-adhesion and/or anti-biofilm activities. ALS3 model was considered stable by DM. The main features of protein flexibility were represented by two conformers which were used in the vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6866ce53aff91ffb7b0dad43c129d54
https://hal.inria.fr/hal-03029420

One Century of Study: What We Learned about Paracoccidioides and How This Pathogen Contributed to Advances in Antifungal Therapy

Autor: Patrícia de Souza Bonfim Mendonça, Larissa Fernandes Matos, Franciele Abigail Vilugron Rodrigues-Vendramini, Ana Karina Rodrigues Abadio, Erika Seki Kioshima, Isis Regina Grenier Capoci, Maria Sueli Soares Felipe, Andre Correa Amaral, Bruna Lauton Simões, Marcus de Melo Teixeira

Publikováno v: Journal of Fungi, Vol 7, Iss 106, p 106 (2021)
Journal of Fungi

Paracoccidioidomycosis (PCM) is a notable fungal infection restricted to Latin America. Since the first description of the disease by Lutz up to the present day, Brazilian researchers have contributed to the understanding of the life cycle of this pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d68cdd91ba21d68d9795003d1c9f438
https://doi.org/10.3390/jof7020106

Antifungal drugs: New insights in researchdevelopment

Autor: Fabrício F. Costa, Anamélia Lorenzetti Bocca, Patrícia Albuquerque, Erika Seki Kioshima, Ana Karina Rodrigues Abadio, Maria Sueli Soares Felipe, Hugo Costa Paes, André Moraes Nicola, Larissa Fernandes

Publikováno v: Pharmacologytherapeutics. 195

The need for better antifungal therapy is commonly accepted in view of the high mortality rates associated with systemic infections, the low number of available antifungal classes, their associated toxicity and the increasing number of infections cau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6385015df6ad88a2e4cedef6c75cefd
https://pubmed.ncbi.nlm.nih.gov/30347212