Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Ana Karin Kusnetzow"'
2
Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism
Autor: Jian Zhao, Shimiao Wang, Sun Hee Kim, Sangdon Han, Elizabeth Rico-Bautista, Emmanuel Sturchler, Julie Nguyen, Hannah Tan, Christine Staley, Ana Karin Kusnetzow, Stephen F. Betz, Michael Johns, Lance Goulet, Rosa Luo, Melissa Fowler, Jon Athanacio, Stacy Markison, R. Scott Struthers, Yunfei Zhu
Publikováno v: Bioorganicmedicinal chemistry letters. 71
SST5 receptor activation potently inhibits insulin secretion from pancreatic β-cells, and an orally available nonpeptide selective SST5 agonist may be used to effectively manage the blood glucose levels of congenital HI patients to avoid severe hypo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08412728bd9e34f60beabf7d56a84d5c
https://pubmed.ncbi.nlm.nih.gov/35605837
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5
OR19-03 Effects of Nonpeptide Orally Bioavailable ACTH Antagonists on Adrenal Gland Size and Function in Rats
Autor: Melissa Fowler, Taylor Kredel, Rosa Luo, Stacy Markison, Shirley Cruz, Ana Karin Kusnetzow, Stephen F. Betz, Scott Struthers, Oleg Tsivkovski, Michael Johns, Agnes Antwan, Greg J. Reinhart, Jon Athanacio, Ajay Madan
Publikováno v: Journal of the Endocrine Society
Cushing’s disease (CD) and Ectopic ACTH syndrome (EAS) stem from excess circulating adrenocorticotropic hormone (ACTH) and resulting hypercortisolemia. In CD, excess ACTH is secreted from pituitary tumors, whereas excess ACTH in EAS arises from non
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cabd2ca03573ef4171b9289897a6290
http://europepmc.org/articles/PMC7209714
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7
SAT-260 Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists Suppress Induced Insulin Secretion in Pancreatic Islets from both Rats and Healthy Human Donors
Autor: Taylor Kredel, Melissa Fowler, Ana Karin Kusnetzow, Jian Zhao, Elizabeth Rico-Bautista, Yun Fei Zhu, Shimiao Wang, Stephen F. Betz, Stacy Markison, Jon Athanacio, Scott Struthers
Publikováno v: Journal of the Endocrine Society
Hyperinsulinemia is a heterogeneous condition in which dangerously low blood sugar levels are caused by improperly regulated insulin secretion from pancreatic ß-cells. The most severe form of hyperinsulinemia arises from congenital hyperinsulinism (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72ae643bc4bc6d9dd781e8b9dca7bc9
https://doi.org/10.1210/js.2019-sat-260
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8
SAT-364 Nonpeptide Orally-Bioavailable ACTH Antagonists: Suppression of ACTH-Induced Corticosterone Secretion and Adrenal Hypertrophy in Rats
Autor: Ana Karin Kusnetzow, Scott Struthers, Michael Johns, Julie Nguyen, Elizabeth Rico-Bautista, Taylor Kredel, Rosa Luo, Yun Fei Zhu, Stacy Markison, Melissa Fowler, Stephen F. Betz, Greg J. Reinhart, Sun Hee Kim, Christine Staley, Sangdon Han, Hannah Tan, Jon Athanacio, Ajay Madan
Publikováno v: Journal of the Endocrine Society
Cushing’s disease is most commonly the result of a microadenoma derived from pituitary corticotrophic cells that secretes excess adrenocorticotropic hormone (ACTH). ACTH is an important modulator of steroidal hormone synthesis and secretion from th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb12b3ec79375e92bb4f3965d9b17dc1
https://doi.org/10.1210/js.2019-sat-364
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9
SAT-169 Selective Nonpeptide Somatostatin Subtype 5 (sst5) Agonists Suppress Glucose- and Sulfonylurea-Induced Insulin Secretion in Rats
Autor: Ana Karin Kusnetzow, Michael Johns, Stacy Markison, Stephen F. Betz, Shimiao Wang, Yun Fei Zhu, Melissa Fowler, Jon Athanacio, Ajay Madan, Scott Struthers, Taylor Kredel, Jian Zhao, Rosa Luo, Emmanuel Sturchler
Publikováno v: Journal of the Endocrine Society
Congenital hyperinsulinism (CHI) results from mutations within the insulin secretion pathway and is characterized by excessive and/or inappropriate insulin secretion by pancreatic islet β-cells. CHI is the most common cause of persistent hypoglycemi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783c4c12e1c369293497cf179ab4b256
http://europepmc.org/articles/PMC6552315
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10
Selective Somatostatin 5 (SST5) and Somatostatin 2 (SST2) Nonpeptide Agonists Potently Suppress Glucose- and Tolbutamide-Stimulated Dynamic Insulin Secretion From Isolated Human Islets
Autor: Ana Karin Kusnetzow, Jian Zhao, Yun Fei Zhu, Mi Chen, Elizabeth Rico, Stephen F. Betz
Publikováno v: Journal of the Endocrine Society
Congenital hyperinsulinism (HI) is the most common cause of persistent hypoglycemia in newborns and infants and arises from dysregulated insulin secretion. Rapid recognition and treatment are vital to prevent seizures, permanent developmental delays,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cc6ebe5ee240af40cbac699557ca48
https://doi.org/10.1210/jendso/bvab048.663
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