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Autor:
K.B. Moller, Ana K. Pedersen, H.S. Andersen, Lars Fogh Iversen, Niels Møller, Günther H.J. Peters, Xiao Ling Guo, S.B. Mortensen, Jette S. Kastrup, Zhong Yin Zhang
Publikováno v:
Biochemical Journal. 378:421-433
Previous enzyme kinetic and structural studies have revealed a critical role for Asp181 (PTP1B numbering) in PTP (protein-tyrosine phosphatase)-mediated catalysis. In the E-P (phosphoenzyme) formation step, Asp181 functions as a general acid, while i