Correction: Suicidal Autointegration of Sleeping Beauty and piggyBac Transposons in Eukaryotic Cells.

Autor: Yongming Wang, Jichang Wang, Anatharam Devaraj, Manvendra Singh, Ana Jimenez Orgaz, Jia-Xuan Chen, Matthias Selbach, Zoltán Ivics, Zsuzsanna Izsvák

Publikováno v: PLoS Genetics, Vol 15, Iss 9, p e1008406 (2019)

[This corrects the article DOI: 10.1371/journal.pgen.1004103.].

Externí odkaz: https://doaj.org/article/75c30fe471604e5696b4abf863025a1c

Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid–induced mTORC1 signaling

Autor: Arunas Kvainickas, Florian Steinberg, Wenjing Qi, Ana Jimenez-Orgaz, Jörn Dengjel, Luca H. Stehl, Heike Nägele, Zehan Hu, Claudio De Virgilio, Ralf Baumeister, Qian Zhao, Ladislav Dokládal, Dipak Gangurde

Publikováno v: The Journal of Cell Biology

Kvainickas et al. establish that retromer, a coat complex that promotes endosomal recycling, is also required for the activation of the lysosomal mTORC1 complex. Mechanistically, retromer and the retromer-associated protein TBC1D5 separate mTORC1 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8122b7026817320c2fb63e7b1ffd24fd
https://doi.org/10.1083/jcb.201812110

Control of RAB 7 activity and localization through the retromer‐TBC1D5 complex enables RAB 7‐dependent mitophagy

Autor: Stefan Eimer, Ana Jimenez-Orgaz, Heike Nägele, Florian Steinberg, Arunas Kvainickas, Justin Denner, Jörn Dengjel

Publikováno v: The EMBO Journal

Retromer is an endosomal multi‐protein complex that organizes the endocytic recycling of a vast range of integral membrane proteins. Here, we establish an additional retromer function in controlling the activity and localization of the late endosom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6971fdc53a88488565629d76c513cc20
https://doi.org/10.15252/embj.201797128

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50

Autor: Ana Jimenez Orgaz, Arunas Kvainickas, Kate J. Heesom, Jörn Dengjel, Florian Steinberg, Heike Nägele, Britta Diedrich, Peter J. Cullen

Publikováno v: Kvainickas, A, Jimenez Orgaz, A, Nägele, H, Diedrich, B, Heesom, K, Dengjel, J, Cullen, P & Steinberg, F 2017, ' Retromer/WASH dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50 ', Journal of Cell Science, vol. 130, pp. 382-395 . https://doi.org/10.1242/jcs.196758, https://doi.org/10.1242/jcs.196758

Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a525dca08ff35e111b8db1e36ea512
http://doc.rero.ch/record/288525/files/den_rwd.pdf

Suicidal autointegration of Sleeping Beauty and piggyBac transposons in eukaryotic cells

Autor: Jia-Xuan Chen, Zsuzsanna Izsvák, Manvendra K. Singh, Matthias Selbach, Yongming Wang, Anatharam Devaraj, Zoltán Ivics, Jichang Wang, Ana Jimenez Orgaz

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 10, Iss 3, p e1004103 (2014)

Transposons are discrete segments of DNA that have the distinctive ability to move and replicate within genomes across the tree of life. ‘Cut and paste’ DNA transposition involves excision from a donor locus and reintegration into a new locus in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddfb1ff861cabd6bec9ed8453f227627
http://edoc.mdc-berlin.de/13939/1/13939.pdf