ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

Autor: Wenjun Lan, Patricia Santofimia-Castaño, Mirna Swayden, Yi Xia, Zhengwei Zhou, Stephane Audebert, Luc Camoin, Can Huang, Ling Peng, Ana Jiménez-Alesanco, Adrián Velázquez-Campoy, Olga Abián, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Vincent Geli, Philippe Soubeyran, José L. Neira, Juan Iovanna

Publikováno v: JCI Insight, Vol 5, Iss 18 (2020)

Establishing the interactome of the cancer-associated stress protein Nuclear Protein 1 (NUPR1), we found that it binds to several hundreds of proteins, including proteins involved in nuclear translocation, DNA repair, and key factors of the SUMO path

Externí odkaz: https://doaj.org/article/dff985e07dd843578a4d7c43143ee70d

The Paralogue of the Intrinsically Disordered Nuclear Protein 1 Has a Nuclear Localization Sequence that Binds to Human Importin α3

Autor: José L. Neira, Bruno Rizzuti, Ana Jiménez-Alesanco, Olga Abián, Adrián Velázquez-Campoy, Juan L. Iovanna

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 19, p 7428 (2020)

Numerous carrier proteins intervene in protein transport from the cytoplasm to the nucleus in eukaryotic cells. One of those is importin α, with several human isoforms; among them, importin α3 (Impα3) features a particularly high flexibility. The

Externí odkaz: https://doaj.org/article/46af80cc31d24a568a98f8fc76d047aa

Discovery of Diverse Natural Products as Inhibitors of SARS-CoV-2 M

Autor: Jaime, Rubio-Martínez, Ana, Jiménez-Alesanco, Laura, Ceballos-Laita, David, Ortega-Alarcón, Sonia, Vega, Cristina, Calvo, Cristina, Benítez, Olga, Abian, Adrián, Velázquez-Campoy, Timothy M, Thomson, José Manuel, Granadino-Roldán, Patricia, Gómez-Gutiérrez, Juan J, Pérez

Publikováno v: Journal of chemical information and modeling. 61(12)

SARS-CoV-2 is a type of coronavirus responsible for the international outbreak of respiratory illness termed COVID-19 that forced the World Health Organization to declare a pandemic infectious disease situation of international concern at the beginni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f28e1b5eab45ef7d04e036d3e4add04c
https://pubmed.ncbi.nlm.nih.gov/34806382

Seleno-Functionalization of Quercetin Improves the Non-Covalent Inhibition of Mpro and Its Antiviral Activity in Cells against SARS-CoV-2

Autor: Diego Alves, Laura Ceballos-Laita, Bruno Rizzuti, Krzysztof Pyrc, Sonia Vega, Luana Bagnoli, Eder J. Lenardão, Ana Jiménez-Alesanco, Pawel Botwina, David Ortega-Alarcon, Ornelio Rosati, Francesca Marini, Agnieszka Dabrowska, Francesca Mangiavacchi, Olga Abian, Adrián Velázquez-Campoy, Luca Sancineto, Anna Kula-Pacurar, Laura Abenante, Claudio Santi, Elena Menichetti, Sergio F. Fonseca

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7048, p 7048 (2021)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
International Journal of Molecular Sciences
Volume 22
Issue 13
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC

The development of new antiviral drugs against SARS-CoV-2 is a valuable long-term strategy to protect the global population from the COVID-19 pandemic complementary to the vaccination. Considering this, the viral main protease (Mpro) is among the mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabe5945a78f73d0190741b38dbf351b
https://www.mdpi.com/1422-0067/22/13/7048

Enzyme/Nanocopper Hybrid Nanozymes: Modulating Enzyme-like Activity by the Protein Structure for Biosensing and Tumor Catalytic Therapy

Autor: Adrián Velázquez-Campoy, Jose M. Palomo, Noelia Losada-Garcia, Ana Jiménez-Alesanco, Olga Abian

Publikováno v: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
ACS Applied Materials & Interfaces
Digital.CSIC. Repositorio Institucional del CSIC
instname

14 pags., 12 figs., 1 tab.
Artificial enzymes with modulated enzyme-mimicking activities of natural systems represent a challenge in catalytic applications. Here, we show the creation of artificial Cu metalloenzymes based on the generation of Cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df98c43b25338db1a7b2ac0422d41121