Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Ana J. Garcia-Saez"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The permeabilization of the mitochondrial outer membrane to induce apoptosis is regulated by complex interactions between Bcl-2 family members. Here the authors develop a quantitative interactome of a membrane Bcl-2 network and identify a hierarchy o
Externí odkaz:
https://doaj.org/article/ca24f04c17a149e2b6bbdd1ada2b7e7d
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2412 (2020)
Pyroptosis, necroptosis, and ferroptosis are well-characterized forms of regulated necrosis that have been associated with human diseases. During regulated necrosis, plasma membrane damage facilitates the movement of ions and molecules across the bil
Externí odkaz:
https://doaj.org/article/a25d8f3de9184c8195b83d4d7741f608
Autor:
Stephanie Bleicken, Ana J. Garcia-Saez
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 1 (2018)
Apoptosis regulation by Bcl-2 proteins is pivotal for mammalians, not only because it is key for development but also because aberrant apoptosis is prerequisite to severe diseases, like cancer. Recently, we quantified interactions within the Bcl-2 pr
Externí odkaz:
https://doaj.org/article/bcae555ca8d14d7c8a96b2cb68ef1945
Publikováno v:
The Journal of Physical Chemistry A. 127:3490-3496
Ferroptosis is an iron-dependent form of regulated cell death characterized by accumulation of peroxidized lipids and plasma membrane disruption, whose molecular mechanism of execution remains poorly understood. Here, we developed a new optogenetic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0237a8be357417df5707b6f31e904753
https://doi.org/10.1101/2023.03.24.534081
https://doi.org/10.1101/2023.03.24.534081
Publikováno v:
Cell death and differentiation.
BOK is a poorly understood member of the BCL-2 family of proteins that has been proposed to function as a pro-apoptotic, BAX-like effector. However, the molecular mechanism and structural properties of BOK pores remain enigmatic. Here, we show that t
Autor:
Marie-Isabel Aguilar, Kareem Al Nahas, Francisco N. Barrera, Patricia Bassereau, Burkhard Bechinger, Izabella Brand, Amitabha Chattopadhyay, Ronald J. Clarke, William F. DeGrado, Evelyne Deplazes, Marcus Fletcher, Franca Fraternali, Patrick Fuchs, Ana J. Garcia-Saez, Robert Gilbert, Bart W. Hoogenboom, Zack Jarin, Paul O’Shea, Georg Pabst, Sreetama Pal, John M. Sanderson, John M. Seddon, Durba Sengupta, David P. Siegel, Anand Srivastava, D. Peter Tieleman, Madhusmita Tripathy, Johanna Utterström, Robert Vácha, Stefano Vanni, Gregory A. Voth
Publikováno v:
Faraday Discussions. 232:149-171
Autor:
Mibel Aguilar, Kareem Al Nahas, Francisco Barrera, Patricia Bassereau, Margarida Bastos, Paul Beales, Burkhard Bechinger, Boyan Bonev, Izabella Brand, Amitabha Chattopadhyay, William DeGrado, Patrick Fuchs, Ana J. Garcia Saez, Bart Hoogenboom, Shobhna Kapoor, Paula Milán Rodríguez, Justin Molloy, Paul O’Shea, Georg Pabst, Sreetama Pal, Amy Rice, Aurelien Roux, John Sanderson, John Seddon, Lukas K. Tamm, Aishwarya Vijayakumar
Publikováno v:
Faraday Discussions. 232:375-398
Autor:
Mibel Aguilar, Kareem Al Nahas, Francisco Barrera, Patricia Bassereau, Margarida Bastos, Paul Beales, Burkhard Bechinger, Boyan Bonev, Izabella Brand, Amitabha Chattopadhyay, Ronald J. Clarke, William DeGrado, Evelyne Deplazes, Ana J. Garcia Saez, Bart Hoogenboom, Reidar Lund, Paula Milán Rodríguez, Paul O’Shea, Georg Pabst, Sreetama Pal, Aurélien Roux, John Sanderson, Enrico Federico Semeraro, Durba Sengupta, David P. Siegel, Leonie van 't Hag, Aishwarya Vijayakumar, Larisa Zoranić
Publikováno v:
Faraday Discussions. 232:256-281
Autor:
Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N. Melo, Ana J. García-Sáez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract BAX and BAK are proapoptotic members of the BCL2 family that directly mediate mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis execution. However, the molecular architecture of the mitochondrial apoptotic pore
Externí odkaz:
https://doaj.org/article/2bee97a155664393b38bf835ce663f24