Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Ana Igea"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/5fb091e034a4475b8a21cd4838828385
Autor:
Lorena González, Lucía Díaz, Joan Pous, Blazej Baginski, Anna Duran-Corbera, Margherita Scarpa, Isabelle Brun-Heath, Ana Igea, Pau Martin-Malpartida, Lidia Ruiz, Chiara Pallara, Mauricio Esguerra, Francesco Colizzi, Cristina Mayor-Ruiz, Ricardo M. Biondi, Robert Soliva, Maria J. Macias, Modesto Orozco, Angel R. Nebreda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of p38α signaling has been linked to several diseases including inflammation, immune disord
Externí odkaz:
https://doaj.org/article/875e0b5f72914dd0a22c1161dc475f7f
Autor:
Belén Aparicio, David Repáraz, Marta Ruiz, Diana Llopiz, Leyre Silva, Enric Vercher, Patrick Theunissen, Ibon Tamayo, Cristian Smerdou, Ana Igea, Marta Santisteban, Cristina Gónzalez-Deza, Juan J. Lasarte, Sandra Hervás-Stubbs, Pablo Sarobe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune checkpoint inhibitor (ICI)-based immunotherapy in triple negative breast cancer (TNBC) is achieving limited therapeutic results, requiring the development of more potent strategies. Combination of ICI with vaccination strategies would enhance
Externí odkaz:
https://doaj.org/article/3a2ee2360ef7461b9bdbb51a0147e8e8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/0e1683d38c244bea88befdae513176b0
Autor:
Raquel Batlle, Eva Andrés, Lorena Gonzalez, Elisabet Llonch, Ana Igea, Núria Gutierrez-Prat, Antoni Berenguer-Llergo, Angel R. Nebreda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Mesenchymal cells contribute to tumor angiogenesis by regulating proliferation and migration of endothelial cells. Here, the authors show that mesenchymal stem cells also have the ability to acquire an endothelial phenotype upon TGF-β stimulation vi
Externí odkaz:
https://doaj.org/article/0ff11edc0a29452baa3d2896b959e5c3
Autor:
Amparo Martínez-Pérez, Ana Igea, Olivia Estévez, Catarina M. Ferreira, Egídio Torrado, António Gil Castro, Carmen Fernández, Anna-Lena Spetz, Lucille Adam, Moisés López González, Mahavir Singh, Rajko Reljic, África González-Fernández
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Deciphering protection mechanisms against Mycobacterium tuberculosis (Mtb) remains a critical challenge for the development of new vaccines and therapies. We analyze the phenotypic and transcriptomic profile in lung of a novel tuberculosis (TB) nanop
Externí odkaz:
https://doaj.org/article/e3193b8600fc43afa04f6076f210103e
Autor:
Ivan del Barco Barrantes, Camille Stephan-Otto Attolini, Konstantin Slobodnyuk, Ana Igea, Sara Gregorio, Sylwia Gawrzak, Roger R. Gomis, Angel R. Nebreda
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 257-271 (2018)
Summary: Mammary stem and progenitor cells are essential for mammary gland homeostasis and are also candidates for cells of origin of mammary tumors. Here, we have investigated the function of the protein kinase p38α in the mammary gland using mice
Externí odkaz:
https://doaj.org/article/1cdcb52fea14446297d22a6b3b3be2a8
Autor:
Jorge Gómez-Miragaya, Marta Palafox, Laia Paré, Guillermo Yoldi, Irene Ferrer, Sergi Vila, Patricia Galván, Pasquale Pellegrini, Hector Pérez-Montoyo, Ana Igea, Purificación Muñoz, Manel Esteller, Angel R. Nebreda, Ander Urruticoechea, Idoia Morilla, Sonia Pernas, Fina Climent, María Teresa Soler-Monso, Ana Petit, Violeta Serra, Aleix Prat, Eva González-Suárez
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1392-1407 (2017)
Taxanes are a mainstay of treatment for breast cancer, but resistance often develops followed by metastatic disease and mortality. Aiming to reveal the mechanisms underlying taxane resistance, we used breast cancer patient-derived orthoxenografts (PD
Externí odkaz:
https://doaj.org/article/4f17da8dcc6a4c1abea0af3c702c89e0
Autor:
Patrick Aloy, Angel R. Nebreda, Modesto Orozco, Begoña Canovas, Victor Alcalde, Rodrigo Arroyo, Ana Igea, Samira Jaeger
Combinatorial therapeutic approaches are an imperative to improve cancer treatment, because it is critical to impede compensatory signaling mechanisms that can engender drug resistance to individual targeted drugs. Currently approved drug combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3634f37328d97ede85438321877da8be
https://doi.org/10.1158/0008-5472.c.6509207
https://doi.org/10.1158/0008-5472.c.6509207
Autor:
Patrick Aloy, Angel R. Nebreda, Modesto Orozco, Begoña Canovas, Victor Alcalde, Rodrigo Arroyo, Ana Igea, Samira Jaeger
Overview on the predicted drug combinations together with the pathways mainly involved in crosstalk inhibition (Excel table).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589a6937de4d33af5c5c464fdabb91fe
https://doi.org/10.1158/0008-5472.22415231.v1
https://doi.org/10.1158/0008-5472.22415231.v1