Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition

Autor: Kathryn S. Potts, Rosannah C. Cameron, Amina Metidji, Noura Ghazale, LaShanale Wallace, Ana I. Leal-Cervantes, Reid Palumbo, Juan Martin Barajas, Varun Gupta, Srinivas Aluri, Kith Pradhan, Jacquelyn A. Myers, Mia McKinstry, Xiaoying Bai, Gaurav S. Choudhary, Aditi Shastri, Amit Verma, Esther A. Obeng, Teresa V. Bowman

Publikováno v: Cell Reports. 41:111825

Hematopoietic stem and progenitor cells (HSPCs) sustain lifelong hematopoiesis. Mutations of pre-mRNA splicing machinery, especially splicing factor 3b, subunit 1 (SF3B1), are early lesions found in malignancies arising from HSPC dysfunction. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f838f703d2ac341d0902023631c6bf5c
https://doi.org/10.1016/j.celrep.2022.111825

Land‐use intensification promotes non‐native species in a tropical island bird assemblage

Autor: A. Santana, Ana I. Leal, Jorge M. Palmeirim, E. Soares, M. Panisi, Hermano Sampaio, Graeme M. Buchanan, Ricardo Franco de Lima, F. C. Soares

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Habitat loss and non-native species are two key drivers of biodiversity decline. The importance of their interactions is widely recognized, but remains poorly understood. We used the endemic-rich bird assemblage of São Tomé Island to study this typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505272d9fd17395de8228efdcbf8f546

Grazing improves habitat suitability for many ground foraging\ud birds in Mediterranean wooded grasslands

Autor: Marta Acácio, Christoph F. J. Meyer, Ana Rainho, Ana I. Leal, Jorge M. Palmeirim

Wooded grasslands, usually grazed, cover vast areas in Southern Europe and Northern Africa. They host rich resident bird communities and, in winter, receive large numbers of migrants from Central and Northern European woodlands. Many species are part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c207bf0ce804f223dd8a93ecfdaa2260

Localized conformational changes trigger the pH-induced fibrillogenesis of an amyloidogenic λ light chain protein

Autor: Sergio Romero Romero, Gilberto Valdés-García, Ana I. Leal-Cervantes, Carlos Amero, Nina Pastor, Isabel Velázquez-López, Rosana Sánchez-López, D. Alejandro Fernández Velasco, Roberto Maya Martínez, Miguel Costas

Publikováno v: Biochimica et biophysica acta. General subjects. 1862(7)

Solvent conditions modulate the expression of the amyloidogenic potential of proteins. In this work the effect of pH on the fibrillogenic behavior and the conformational properties of 6aJL2, a model protein of the highly amyloidogenic variable light

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed2b621b70ab0e604f8d280f02f7e7b
https://pubmed.ncbi.nlm.nih.gov/29669263

Long-term declines of wader populations at the Tagus estuary, Portugal

Autor: Vitor Encarnação, Joana Andrade, Ricardo C. Martins, Filipe Moniz, Helder Costa, Pedro Fernandes, Ana I. Leal, Sara Pardal, Afonso D. Rocha, Maria P. Dias, José A. Alves, Pedro M. Lourenço, Carlos David Santos, Teresa Catry, José Pedro Granadeiro

Publikováno v: Bird Conservation International, 21(4), 438-453. Cambridge University Press
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Migratory wader populations face global threats, mainly related to increasing rates of habitat loss and disturbance driven by human activities. To a large extent, the long-term survival of these populations requires the conservation of networks of si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb66b23359a29102a9e26472225c4602
https://doi.org/10.1017/S0959270910000626