Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ana I. Costa"'
Autor:
Tom Cremer, Hanneke Hoelen, Michael L. van de Weijer, George M. Janssen, Ana I. Costa, Peter A. van Veelen, Robert Jan Lebbink, Emmanuel J. H. J. Wiertz
Publikováno v:
PLoS ONE, Vol 19, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/f36f4e875d71455c9574263e53db85d0
Autor:
Rutger D. Luteijn, Patrique Praest, Frank Thiele, Saravanan Manikam Sadasivam, Katrin Singethan, Jan W. Drijfhout, Christian Bach, Steffen Matthijn de Boer, Robert J. Lebbink, Sha Tao, Markus Helfer, Nina C. Bach, Ulrike Protzer, Ana I. Costa, J. Antoinette Killian, Ingo Drexler, Emmanuel J. H. J. Wiertz
Publikováno v:
Cells, Vol 9, Iss 9, p 1989 (2020)
The ongoing threat of viral infections and the emergence of antiviral drug resistance warrants a ceaseless search for new antiviral compounds. Broadly-inhibiting compounds that act on elements shared by many viruses are promising antiviral candidates
Externí odkaz:
https://doaj.org/article/58bd89e9563747248b0b2cd4d22db3fd
Autor:
Michael L. van de Weijer, Guus H. van Muijlwijk, Linda J. Visser, Ana I. Costa, Emmanuel J. H. J. Wiertz, Robert Jan Lebbink
Publikováno v:
Viruses, Vol 8, Iss 11, p 309 (2016)
Misfolded proteins from the endoplasmic reticulum (ER) are transported back into the cytosol for degradation via the ubiquitin-proteasome system. The human cytomegalovirus protein US11 hijacks this ER-associated protein degradation (ERAD) pathway to
Externí odkaz:
https://doaj.org/article/392f1c7f90794d13b64d41d3a4ad0e9f
Autor:
Ingrid G. J. Boer, M. L. van de Weijer, Emmanuel J. H. J. Wiertz, Anouk B. C. Schuren, P. Hubel, Robert Jan Lebbink, Ana I. Costa, Esther M. C. Bouma, Andreas Pichlmair
Publikováno v:
Molecules
Molecules, Vol 26, Iss 287, p 287 (2021)
Molecules, 26(2):287. MDPI AG
Volume 26
Issue 2
Molecules, Vol 26, Iss 287, p 287 (2021)
Molecules, 26(2):287. MDPI AG
Volume 26
Issue 2
To prevent accumulation of misfolded proteins in the endoplasmic reticulum, chaperones perform quality control on newly translated proteins and redirect misfolded proteins to the cytosol for degradation by the ubiquitin-proteasome system. This pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403db02ec4564ca0b701e9b2b4e9f67e
https://hdl.handle.net/21.11116/0000-0008-2B0A-E21.11116/0000-0008-2B0C-C21.11116/0000-0008-2B0D-B
https://hdl.handle.net/21.11116/0000-0008-2B0A-E21.11116/0000-0008-2B0C-C21.11116/0000-0008-2B0D-B
Publikováno v:
Current Opinion in Immunology. 40:43-50
T-cell mediated adaptive immunity against viruses relies on recognition of virus-derived peptides by CD4(+) and CD8(+) T cells. Detection of pathogen-derived peptide-MHC-I complexes triggers CD8(+) T cells to eliminate the infected cells. Viruses hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441af3cf0ab2fda1590afed14ab3a125
https://doi.org/10.1016/j.coi.2016.02.007
https://doi.org/10.1016/j.coi.2016.02.007
Publikováno v:
The Journal of Immunology. 182:1526-1532
Conventional CD8+ T cell responses against intracellular infectious agents are initiated upon recognition of pathogen-derived peptides presented at the cell surface of infected cells in the context of MHC class I molecules. Among the major MHC class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c0487cc3a135c2adc3e65aa1077603
https://doi.org/10.4049/jimmunol.182.3.1526
https://doi.org/10.4049/jimmunol.182.3.1526
Autor:
Ingrid eSchellens, Hugo D Meiring, Ilka eHoof, Sanne eSpijkers, Martien C.M. Poelen, Jacqueline A.M. van Gaans-van den Brink, Ana I Costa, Harry eVennema, Can eKesmir, Debbie eVan Baarle, Cecile A.C.M. Van Els
Publikováno v:
Frontiers in Immunology [E], 6(NOV). Frontiers Media S.A.
Frontiers in Immunology
Frontiers in Immunology, Vol 6 (2015)
Frontiers in Immunology
Frontiers in Immunology, Vol 6 (2015)
Immunity to infections with Measles Virus (MV) can involve vigorous HLA class I restricted CD8+ cytotoxic T cell (CTL) responses. MV, albeit regarded monotypic, is known to undergo molecular evolution across its RNA genome. To address which regions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21ded353c34f04100370f446a6733af
https://dspace.library.uu.nl/handle/1874/327999
https://dspace.library.uu.nl/handle/1874/327999
Autor:
Ilka Hoof, John J. Miles, Kristin Ladell, David Price, Vanessa Venturi, Ingrid M. M. Schellens, Ana I. Costa, Nening M. Nanlohy, Can Keşmir, José A. M. Borghans, Debbie van Baarle, Dan Koning, Katherine K. Matthews
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 190(3)
CD8+ T cells recognize infected or dysregulated cells via the clonotypically expressed αβ TCR, which engages Ag in the form of peptide bound to MHC class I (MHC I) on the target cell surface. Previous studies have indicated that a diverse Ag-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b104979a3ef188819d003333862d702
https://pubmed.ncbi.nlm.nih.gov/23267020
https://pubmed.ncbi.nlm.nih.gov/23267020
Publikováno v:
Immunogenetics
The peptide repertoire presented on human leukocyte antigen (HLA) class I molecules is largely determined by the structure of the peptide binding groove. It is expected that the molecules having similar grooves (i.e., belonging to the same supertype)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8f16c2e3f5640c5e232b6fd325cc06
https://pubmed.ncbi.nlm.nih.gov/21695550
https://pubmed.ncbi.nlm.nih.gov/21695550
Publikováno v:
AIDS (London, England). 24(2)
Background: HLA-B alleles of HIV-infected individuals have been shown to have a major impact on their rate of progression toward AIDS, and the T-cell responses they restrict are immunodominant. Objective: We sought to identify whether the association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854acd0597582abeb6aa22a72619adb7
https://pubmed.ncbi.nlm.nih.gov/19904197
https://pubmed.ncbi.nlm.nih.gov/19904197