Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Ana I. Rojo"'
Autor:
Raquel Fernández-Ginés, José Antonio Encinar, Maribel Escoll, Daniel Carnicero-Senabre, José Jiménez-Villegas, Ángel J. García-Yagüe, Águeda González-Rodríguez, Irma Garcia-Martinez, Ángela M Valverde, Ana I. Rojo, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103027- (2024)
Non-alcoholic steatohepatitis (NASH) is a common chronic liver disease that compromises liver function, for which there is not a specifically approved medicine. Recent research has identified transcription factor NRF2 as a potential therapeutic targe
Externí odkaz:
https://doaj.org/article/55f0658f6cd7407d98a9c86477d2e394
Autor:
Raquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodríguez-Franco, Ana I. Rojo, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102428- (2022)
Externí odkaz:
https://doaj.org/article/dfa2e007ccac4a2f8c36c0c3654b1b32
Autor:
Raquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodríguez-Franco, Ana I. Rojo, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102396- (2022)
It is widely accepted that activating the transcription factor NRF2 will blast the physiological anti-inflammatory mechanisms, which will help combat pathologic inflammation. Much effort is being put in inhibiting the main NRF2 repressor, KEAP1, with
Externí odkaz:
https://doaj.org/article/8fbf945404ce4557a8c1050e17b4a830
Autor:
José Jiménez-Villegas, Janine Kirby, Ana Mata, Susana Cadenas, Martin R. Turner, Andrea Malaspina, Pamela J. Shaw, Antonio Cuadrado, Ana I. Rojo
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 1897 (2022)
The hexanucleotide expansion of the C9orf72 gene is found in 40% of familial amyotrophic lateral sclerosis (ALS) patients. This genetic alteration has been connected with impaired management of reactive oxygen species. In this study, we conducted tar
Externí odkaz:
https://doaj.org/article/982b51010e2142f7aab11af581ca5cf8
Autor:
Maribel Escoll, Diego Lastra, Marta Pajares, Natalia Robledinos-Antón, Ana I. Rojo, Raquel Fernández-Ginés, Marta Mendiola, Virginia Martínez-Marín, Isabel Esteban, Pilar López-Larrubia, Ricardo Gargini, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Transcription factor NRF2 orchestrates a cellular defense against oxidative stress and, so far, has been involved in tumor progression by providing a metabolic adaptation to tumorigenic demands and resistance to chemotherapeutics. In this study, we d
Externí odkaz:
https://doaj.org/article/b8990445efe3436cb0fdd0576778f576
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Nordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata, the creosote bush found in Mexico and USA deserts, that has been used in traditional medicine for the treatment of numerous diseases such as cancer, renal, cardiov
Externí odkaz:
https://doaj.org/article/07f29b4ebb2b448881aa6413a64d8a7b
Autor:
Ana I. Rojo, Marta Pajares, Angel J. García-Yagüe, Izaskun Buendia, Fred Van Leuven, Masayuki Yamamoto, Manuela G. López, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 18, Iss , Pp 173-180 (2018)
Chronic neuroinflammation is a hallmark of the onset and progression of brain proteinopathies such as Alzheimer disease (AD) and it is suspected to participate in the neurodegenerative process. Transcription factor NRF2, a master regulator of redox h
Externí odkaz:
https://doaj.org/article/b2146730596b411ea0a1cdc33d1d8c9a
Autor:
Ana I. Rojo, Marta Pajares, Patricia Rada, Angel Nuñez, Alejo J. Nevado-Holgado, Richard Killik, Fred Van Leuven, Elena Ribe, Simon Lovestone, Masayuki Yamamoto, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 444-451 (2017)
Failure to translate successful neuroprotective preclinical data to a clinical setting in Alzheimer's disease (AD) indicates that amyloidopathy and tauopathy alone provide an incomplete view of disease. We have tested here the relevance of additional
Externí odkaz:
https://doaj.org/article/d68186949f744c309d22a00c4b5bae87
Autor:
Natalia Robledinos-Antón, Ana I. Rojo, Elisabete Ferreiro, Ángel Núñez, Karl-Heinz Krause, Vincent Jaquet, Antonio Cuadrado
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 393-401 (2017)
Neural stem/progenitor cells (NSPCs) located at the subgranular zone (SGZ) of the hippocampus participate in the maintenance of synaptic networks that ensure cognitive functions during life. Although it is known that this neurogenic niche losses acti
Externí odkaz:
https://doaj.org/article/eceae8c7d282437d873979a02662310e
Publikováno v:
Redox Biology, Vol 11, Iss , Pp 543-553 (2017)
Neurodegenerative diseases are linked to the accumulation of specific protein aggregates, suggesting an intimate connection between injured brain and loss of proteostasis. Proteostasis refers to all the processes by which cells control the abundance
Externí odkaz:
https://doaj.org/article/1d7c1d4f32be4a5bae6e68268d2d6c58