Growth Hormone Modulation of Hepatic Epidermal Growth Factor Receptor Signaling

Autor: María E. Díaz, Johanna G. Miquet, Fernando P. Dominici, Ana I. Sotelo, Lorena Gonzalez

Publikováno v: Trends in Endocrinology & Metabolism. 32:403-414

Epidermal growth factor receptor (EGFR) signaling has a central role in the regenerative response of the liver upon injury and is involved in cellular transformation linked to chronic damage. Hepatic EGFR expression, trafficking, and signaling are re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1d7b57760f86d631a3cb6945f12c44
https://doi.org/10.1016/j.tem.2021.03.004

Insulin signaling in the heart is impaired by growth hormone: a direct and early event

Autor: Marina C Muñoz, Verónica G Piazza, Valeria Burghi, Jorge F Giani, Carolina S Martinez, Nadia S Cicconi, Nadia V Muia, Yimin Fang, Sergio Lavandero, Ana I Sotelo, Andrzej Bartke, Patricia A Pennisi, Fernando P Dominici, Johanna G Miquet

Publikováno v: Journal of molecular endocrinology. 69(2)

Growth hormone (GH) exerts major actions in cardiac growth and metabolism. Considering the important role of insulin in the heart and the well-established anti-insulin effects of GH, cardiac insulin resistance may play a role in the cardiopathology o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba75191bf0127fb889f2c6c12c54799
https://pubmed.ncbi.nlm.nih.gov/35608964

Mitogenic signaling pathways in the liver of growth hormone (GH)-overexpressing mice during the growth period

Autor: Ana I. Sotelo, Verónica Gabriela Piazza, Andrzej Bartke, Johanna G. Miquet, Lorena Gonzalez, Carolina Martínez, Yimin Fang, Daniel Turyn

Publikováno v: Cell Cycle. 15:748-759

Growth hormone (GH) is a pleiotropic hormone that triggers STATs, ERK1/2 and Akt signaling, related to cell growth and proliferation. Transgenic mice overexpressing GH present increased body size, with a disproportionate liver enlargement due to hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eed437d76624d717070ac24e5e2b80d
https://doi.org/10.1080/15384101.2016.1148844

A laboratory work to introduce biochemistry undergraduate students to basic enzyme kinetics-alkaline phosphatase as a model

Autor: Rodolfo M. González Lebrero, Lorena Gonzalez, Ana I. Sotelo, Johanna G. Miquet

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Enzyme kinetics is an essential topic in undergraduate Biochemistry courses. A laboratory work that covers the principal basic concepts of enzyme kinetics in steady state is presented. The alkaline phosphatase catalyzed reaction of phenyl-phosphate h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34e127b41aaa46fa0cf0b15dc2426a1
https://pubmed.ncbi.nlm.nih.gov/30576049

Analysis of Different Approaches for the Selection of Reference Genes in RT-qPCR Experiments: A Case Study in Skeletal Muscle of Growing Mice

Autor: Andrzej Bartke, Ana I. Sotelo, Verónica Gabriela Piazza, Johanna G. Miquet

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 5; Pages: 1060

The reliability of reverse transcription-quantitative PCR (RT-qPCR) results in gene expression studies depends on the approaches used to account for non-biological variations. In order to find a proper normalization strategy for the study of genes re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6349ec1f0c4953fbab7c58b34cb81210
http://www.mdpi.com/1422-0067/18/5/1060