Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ana I Casas"'
Autor:
Steffen Haupeltshofer, Stine Mencl, Rebecca D. Szepanowski, Christina Hansmann, Ana I. Casas, Hanna Abberger, Wiebke Hansen, Alina Blusch, Cornelius Deuschl, Michael Forsting, Dirk M. Hermann, Friederike Langhauser, Christoph Kleinschnitz
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Activation of the kallikrein-kinin system promotes vascular leakage, inflammation, and neurodegeneration in ischemic stroke. Inhibition of plasma kallikrein (PK) – a key component of the KKS – in the acute phase of ischemic stroke has be
Externí odkaz:
https://doaj.org/article/47314db5edc8456c8ff87473e47850e1
Autor:
Ana I. Casas, Ahmed A. Hassan, Quirin Manz, Christian Wiwie, Pamela Kleikers, Javier Egea, Manuela G. López, Markus List, Jan Baumbach, Harald H. H. W. Schmidt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Differential gene expression normalised to a single housekeeping (HK) is used to identify disease mechanisms and therapeutic targets. HK gene selection is often arbitrary, potentially introducing systematic error and discordant results. Here
Externí odkaz:
https://doaj.org/article/f695aab77cc14bc98cf8a63fc3f54100
Autor:
Alejandra Palomino-Antolín, Céline Decouty-Pérez, Víctor Farré-Alins, Paloma Narros-Fernández, Ana Belen Lopez-Rodriguez, María Álvarez-Rubal, Inés Valencia, Francisco López-Muñoz, Eva Ramos, Antonio Cuadrado, Ana I. Casas, Alejandro Romero, Javier Egea
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1729 (2023)
The role of inflammation and immunity in the pathomechanism of neurodegenerative diseases has become increasingly relevant within the past few years. In this context, the NOD-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in the ac
Externí odkaz:
https://doaj.org/article/552434a0330b4ac5ab6087e7cbc3bf4f
Autor:
Sepideh Sadegh, James Skelton, Elisa Anastasi, Judith Bernett, David B. Blumenthal, Gihanna Galindez, Marisol Salgado-Albarrán, Olga Lazareva, Keith Flanagan, Simon Cockell, Cristian Nogales, Ana I. Casas, Harald H. H. W. Schmidt, Jan Baumbach, Anil Wipat, Tim Kacprowski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
There is an unmet need for adaptable tools allowing biomedical researchers to employ network-based drug repurposing approaches for their individual use cases. Here, the authors close this gap with NeDRex, an integrative and interactive platform.
Externí odkaz:
https://doaj.org/article/215680eb37af47198ac9250590ddadb5
Autor:
Rebecca D. Steubing, Fabian Szepanowski, Christina David, Ayan Mohamud Yusuf, Stine Mencl, Anne-Kathrin Mausberg, Harald F. Langer, Manuela Sauter, Cornelius Deuschl, Michael Forsting, Anke C. Fender, Dirk M. Hermann, Ana I. Casas, Friederike Langhauser, Christoph Kleinschnitz
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 24, Iss , Pp 100493- (2022)
Platelets are key mediators of thrombus formation and inflammation during the acute phase of ischaemic stroke. Particularly, the platelet glycoprotein (GP) receptors GPIbα and GPVI have been shown to mediate platelet adhesion and activation in the i
Externí odkaz:
https://doaj.org/article/f73f2d595ae0433c87b3d9d337e41989
Autor:
Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández-Mendívil, Ángel Nuñez, Marta del Campo, César Porrero, Nuria García-Magro, Pilar Negredo, Sergio Senar, Cristina Sánchez-Ramos, Juan A. Bernal, Alberto Rábano, Jeroen Hoozemans, Ana I. Casas, Harald H.H.W. Schmidt, Manuela G. López
Publikováno v:
Redox Biology, Vol 49, Iss , Pp 102210- (2022)
Aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as Alzheimer's disease (AD) and frontotemporal dementia. Therapeutic strategies based on tau have failed i
Externí odkaz:
https://doaj.org/article/b296e0e1f5164ab596b4e26bd355baf6
Autor:
Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes, Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertrán, Alberto Bindoli, Serge P. Bottari, Paula M. Brito, Guia Carrara, Ana I. Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S. Cooke, João G. Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge Debelec–Butuner, Irundika H.K. Dias, Joe Dan Dunn, Amanda J. Edson, Mariam El Assar, Jamel El-Benna, Péter Ferdinandy, Ana S. Fernandes, Kari E. Fladmark, Ulrich Förstermann, Rashid Giniatullin, Zoltán Giricz, Anikó Görbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustín, Melanie Hillion, Jingjing Huang, Serap Ilikay, Pidder Jansen-Dürr, Vincent Jaquet, Jaap A. Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars-Oliver Klotz, Bato Korac, Kemal Sami Korkmaz, Rafal Koziel, Damir Kračun, Karl-Heinz Krause, Vladimír Křen, Thomas Krieg, João Laranjinha, Antigone Lazou, Huige Li, Antonio Martínez-Ruiz, Reiko Matsui, Gethin J. McBean, Stuart P. Meredith, Joris Messens, Verónica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milković, Antonio Miranda-Vizuete, Miloš Mojović, María Monsalve, Pierre-Alexis Mouthuy, John Mulvey, Thomas Münzel, Vladimir Muzykantov, Isabel T.N. Nguyen, Matthias Oelze, Nuno G. Oliveira, Carlos M. Palmeira, Nikoletta Papaevgeniou, Aleksandra Pavićević, Brandán Pedre, Fabienne Peyrot, Marios Phylactides, Gratiela G. Pircalabioru, Andrew R. Pitt, Henrik E. Poulsen, Ignacio Prieto, Maria Pia Rigobello, Natalia Robledinos-Antón, Leocadio Rodríguez-Mañas, Anabela P. Rolo, Francis Rousset, Tatjana Ruskovska, Nuno Saraiva, Shlomo Sasson, Katrin Schröder, Khrystyna Semen, Tamara Seredenina, Anastasia Shakirzyanova, Geoffrey L. Smith, Thierry Soldati, Bebiana C. Sousa, Corinne M. Spickett, Ana Stancic, Marie José Stasia, Holger Steinbrenner, Višnja Stepanić, Sebastian Steven, Kostas Tokatlidis, Erkan Tuncay, Belma Turan, Fulvio Ursini, Jan Vacek, Olga Vajnerova, Kateřina Valentová, Frank Van Breusegem, Lokman Varisli, Elizabeth A. Veal, A. Suha Yalçın, Olha Yelisyeyeva, Neven Žarković, Martina Zatloukalová, Jacek Zielonka, Rhian M. Touyz, Andreas Papapetropoulos, Tilman Grune, Santiago Lamas, Harald H.H.W. Schmidt, Fabio Di Lisa, Andreas Daiber
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 94-162 (2017)
The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated t
Externí odkaz:
https://doaj.org/article/637c0e34ca5240b4924d5b20463b39fc
Autor:
Simon F. De Meyer, Friederike Langhauser, Steffen Haupeltshofer, Christoph Kleinschnitz, Ana I. Casas
Publikováno v:
Stroke. 53(5):1487-1499
Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation,
Autor:
Alexandra Petraina, Mahmoud H. Elbatreek, Christopher T. Neullens, Theodora Saridaki, Vu Thao-vi Dao, Ana I Casas, Harald HHW. Schmidt
Nitric oxide (NO) is a widely distributed gasotransmitter binding to the heme of soluble guanylate cyclase (sGC) to stimulate the formation of the second messenger cyclic GMP. In disease, two pathomechanisms can occur, scavenging of NO by reactive ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::986bb97211be495af6c890cfdb570a3e
https://doi.org/10.14293/s2199-1006.1.sor-.ppw9ffl.v2
https://doi.org/10.14293/s2199-1006.1.sor-.ppw9ffl.v2
Autor:
Zeinab M. Mamdouh, Elisa Anastasi, Ahmed A. Hassan, Johannes Boltze, Mahmoud H. Elbatreek, Cristian Nogales, Mayra Pacheco Pachado, Alexandra Petraina, Zina Piper, Alejandro Rodríguez-González, Anil Wipat, Edwin K. Silverman, Ana I Casas, Emre Guney, Harald H.H.W. Schmidt
Noncommunicable diseases (NCDs) have become globally abundant, yet the therapeutics we use for them are imprecise. In parallel, identifying new treatments has become more costly than ever due to the ever-aggravating efficacy crisis drug discovery fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313b99d8801e5261a022f3e86efb375d
https://doi.org/10.14293/s2199-1006.1.sor-.ppcfydy.v1
https://doi.org/10.14293/s2199-1006.1.sor-.ppcfydy.v1