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Data from Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura

Autor: Seth M. Steinberg, Anthony J. Murgo, William D. Figg, Vitaliy Pishchik, G. Aaron Chen, Julie A. Hong, Ana Hancox, Tricia F. Kunst, Xinmin Li, Ming Zhao, Dao M. Nguyen, Maria R. Fischette, David S. Schrump

Purpose: The DNA methylation paradox, manifested as derepression of cancer-testis antigens, and silencing of tumor suppressors during malignant transformation, provides the rationale for the utilization of chromatin remodeling agents for cancer thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882f9fc79a7ff61fe6b4d2aa8704df79
https://doi.org/10.1158/1078-0432.c.6518526.v1

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Supplementary Figure 1 from Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura

Supplementary Figure 1 from Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9f335f1e214fae11ec131f72ab38a9
https://doi.org/10.1158/1078-0432.22441464

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Supplementary Table 1 from Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura

Supplementary Table 1 from Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056e62cb7b06f5ff10351900587f6b17
https://doi.org/10.1158/1078-0432.22441461.v1

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Clinical and Molecular Responses in Lung Cancer Patients Receiving Romidepsin

Autor: William D. Figg, Maria R. Fischette, Tricia F. Kunst, E. Kruchin, Julie A. Hong, David S. Schrump, John Wright, Xin-Min Li, M. Zhao, G.A. Chen, Seth M. Steinberg, Dao M. Nguyen, Alex Sparreboom, Douglas R. Rosing, Ana Hancox

Publikováno v: Clinical Cancer Research. 14:188-198

Purpose Our published preclinical experiments have indicated that romidepsin mediates growth arrest and apoptosis in lung cancer cells (but not cultured normal bronchial epithelia) via chromatin remodeling mechanisms. Also, romidepsin has direct effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac9678b30395bd39eb92d075352a155
https://doi.org/10.1158/1078-0432.ccr-07-0135

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Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura

Autor: Seth M. Steinberg, G. Aaron Chen, Ming Zhao, Maria R. Fischette, Tricia F. Kunst, Ana Hancox, William D. Figg, Vitaliy Pishchik, Dao M. Nguyen, Xin-Min Li, Anthony J. Murgo, David S. Schrump, Julie A. Hong

Publikováno v: Clinical Cancer Research. 12:5777-5785

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fc755d7338844c44fdf1ed2549011c
https://doi.org/10.1158/1078-0432.ccr-06-0669

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Phase I Study of Sequential Deoxyazacytidine/Depsipeptide Infusion in Patients with Malignancies Involving Lungs or Pleura

Autor: Vitality Pishchik, William D. Figg, David S. Schrump, Tricia E Kunst, Dao M. Nguyen, Yvonne Becerra, Seth M. Steinberg, Ana Hancox

Publikováno v: Clinical Lung Cancer. 4:186-192

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698672690648249c781732c6c922bff0
https://doi.org/10.3816/clc.2002.n.027

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Clinical and immunologic assessment of patients with psoriasis in a randomized, double-blind, placebo-controlled trial using recombinant human interleukin 10

Autor: Tatsuyoshi Kawamura, Alexa B. Kimball, Krupali Tejura, Maria L. Turner, Ana Hancox, Jonathan C. Vogel, Seth M. Steinberg, Carol Boss, Andrew Blauvelt

Publikováno v: Archives of dermatology. 138(10)

Background In several open-label studies, recombinant human interleukin 10 (rhIL-10), a type 2 anti-inflammatory cytokine, has been reported to improve psoriasis, a disease characterized by type 1 cytokine inflammation. Objective To evaluate the safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a341adf3d77a983135481d79b1cc8c
https://pubmed.ncbi.nlm.nih.gov/12374540

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