Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ana Granat"'
Autor:
M. Kyle Cromer, Valentin V. Barsan, Erich Jaeger, Mengchi Wang, Jessica P. Hampton, Feng Chen, Drew Kennedy, Jenny Xiao, Irina Khrebtukova, Ana Granat, Tiffany Truong, Matthew H. Porteus
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
As CRISPR-based therapies enter the clinic, evaluation of safety remains a critical and active area of study. Here the authors use next generation sequencing to achieve high sequencing depth and demonstrate that clinically relevant delivery of high-f
Externí odkaz:
https://doaj.org/article/b2458959b697451c94116da162dba33a
Autor:
Maryellen de Mars, Cu Nguyen, Tiffany Hung, Eric Peters, Charles Lu, Meijian Guan, Bao Tran, Maurizio Polano, Bin Zhu, Samir Lababidi, Wendell D. Jones, Chunlin Xiao, Andreas Scherer, K J. Langenbach, Zhipan Li, Luyao Ren, Weida Tong, Erich Jaeger, Rebecca Kusko, Zivana Tezak, Ying Yu, Ulrika Liljedahl, Louis M. Staudt, Huixiao Hong, Jing Wang, Yuanting Zheng, Ali Moshrefi, Cristobal Juan Vera, Chris Miller, Rasika Kalamegham, Arati Raziuddin, Howard Jacob, Roberta Maestro, Bindu Swapna Madala, Petr Vojta, Jessica Nordlund, Li Tai Fang, Jiri Drabek, Xuelu Liu, Corey Miles, Gary P. Schroth, Fayaz Seifuddin, Tim R. Mercer, Chunhua Yan, Leihong Wu, Sulev Kõks, Roderick V. Jensen, Jennifer A Hipp, Yun-Ching Chen, Malcolm Moos, Yongmei Zhao, Baitang Ning, Aparna Natarajan, Brian N. Papas, Xin Chen, Ashley Walton, Stephen T. Sherry, Christopher E. Mason, Liz Kerrigan, Ogan D Abaan, Wanqiu Chen, Kenneth Idler, Jingya Wang, Tsai-wei Shen, James C. Willey, Ene Reimann, Justin B. Lack, Virginie Petitjean, Jyoti Shetty, Daoud Meerzaman, Charles Wang, Jian-Liang Li, Tiffany Truong, Keyur Talsania, Mehdi Pirooznia, Marc Sultan, Urvashi Mehra, Wenming Xiao, Zhong Chen, Ana Granat, Leming Shi, Margaret C. Cam, Qing-Rong Chen, Eric F. Donaldson, Wolfgang Resch, Ben Ernest, Yuliya Kriga, Gokhan Yavas, Thomas M. Blomquist, Parthav Jailwala
Publikováno v:
Nat Biotechnol
Clinical applications of precision oncology require accurate tests that can distinguish true cancer-specific mutations from errors introduced at each step of next-generation sequencing (NGS). To date, no bulk sequencing study has addressed the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef22c7577b25ad8e9614f7e477a68e7
https://doi.org/10.1038/s41587-021-00994-5
https://doi.org/10.1038/s41587-021-00994-5
Autor:
M. Kyle Cromer, Valentin V. Barsan, Erich Jaeger, Mengchi Wang, Jessica P. Hampton, Feng Chen, Drew Kennedy, Jenny Xiao, Irina Khrebtukova, Ana Granat, Tiffany Truong, Matthew H. Porteus
Publikováno v:
Nature communications. 13(1)
As CRISPR-based therapies enter the clinic, evaluation of safety remains a critical and active area of study. Here, we employ a clinical next generation sequencing (NGS) workflow to achieve high sequencing depth and detect ultra-low frequency variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b838983e2ceb94df8430032fed66982
https://pubmed.ncbi.nlm.nih.gov/35953477
https://pubmed.ncbi.nlm.nih.gov/35953477
Autor:
M. Kyle Cromer, Matthew H. Porteus, Mengchi Wang, Feng Chen, Irina Khrebtukova, Drew Kennedy, Ana Granat, Tiffany Truong, Jessica P. Hampton, Erich Jaeger, Valentin Barsan
As CRISPR-based therapies enter the clinic, evaluation of the safety remains a critical and still active area of study. While whole genome sequencing is an unbiased method for identifying somatic mutations introduced by ex vivo culture and genome edi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e0d89ed3743e555e2501cc90ab7ec0e
https://doi.org/10.1101/2021.10.27.466166
https://doi.org/10.1101/2021.10.27.466166
Autor:
Niall Anthony Gormley, Maria C Rogert, Jerushah Thomas, Lena Christiansen, Ana Granat, Ros Jackson, Frank J. Steemers, Jay Shendure, Yannan Zhao, Mostafa Ronaghi, Aaron L. Halpern, Melissa M. Wiley, Dmitry K. Pokholok, Steven Norberg, Fan Zhang, Emily Welch, Erich Jaeger, Kevin L. Gunderson, Natalie Morrell
Publikováno v:
Nature biotechnology. 35(9)
Haplotype-resolved genome sequencing promises to unlock a wealth of information in population and medical genetics. However, for the vast majority of genomes sequenced to date, haplotypes have not been determined because of cumbersome haplotyping wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c376886523188e91c2dedc2fa0acdc36
https://pubmed.ncbi.nlm.nih.gov/28650462
https://pubmed.ncbi.nlm.nih.gov/28650462
Publikováno v:
FEMS microbiology letters. 285(2)
Escherichia coli hemolysin, also termed alpha-hemolysin, is a virulence factor for extraintestinal E. coli. Hemolysin operon (hlyCABD) transcription is inhibited by the nucleoid-associated protein, H-NS. This inhibition is stronger at lower growth te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fc7dbe4c8efd8e4f52a8a316db475c
https://pubmed.ncbi.nlm.nih.gov/18616595
https://pubmed.ncbi.nlm.nih.gov/18616595