ERK MAPK signaling pathway inhibition as a potential target to prevent autophagy alterations in Spinal Muscular Atrophy motoneurons

Autor: Alba Sansa, Maria P. Miralles, Maria Beltran, Ferran Celma-Nos, Jordi Calderó, Ana Garcera, Rosa M. Soler

Publikováno v: Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)

Abstract Spinal Muscular Atrophy (SMA) is a severe genetic neuromuscular disorder that occurs in childhood and is caused by misexpression of the survival motor neuron (SMN) protein. SMN reduction induces spinal cord motoneuron (MN) degeneration, whic

Externí odkaz: https://doaj.org/article/7f17bffa2fa34d3ba5d982e79730d9e4

Spinal Muscular Atrophy autophagy profile is tissue-dependent: differential regulation between muscle and motoneurons

Autor: Alba Sansa, Ivan Hidalgo, Maria P. Miralles, Sandra de la Fuente, M. Jose Perez-Garcia, Francina Munell, Rosa M. Soler, Ana Garcera

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-15 (2021)

Abstract Spinal muscular atrophy (SMA) is a neuromuscular genetic disease caused by reduced survival motor neuron (SMN) protein. SMN is ubiquitous and deficient levels cause spinal cord motoneurons (MNs) degeneration and muscle atrophy. Nevertheless,

Externí odkaz: https://doaj.org/article/6519b01e036441a5a70343d791779e8b

Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1

Autor: Victoria García-Morales, Guillermo Rodríguez-Bey, Laura Gómez-Pérez, Germán Domínguez-Vías, David González-Forero, Federico Portillo, Antonio Campos-Caro, Ángela Gento-Caro, Noura Issaoui, Rosa M. Soler, Ana Garcera, Bernardo Moreno-López

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-23 (2019)

The adaptor protein p11 and K+ channel TASK1 have overlapping distributions in the CNS. Here, the authors demonstrate that the transcription factor Sp1 regulates p11 levels, which in turn affects intrinsic membrane properties and can contribute to de

Externí odkaz: https://doaj.org/article/20e757cfad114f6fb6a76661d270846b

A new model to study spinal muscular atrophy: Neurite degeneration and cell death is counteracted by BCL-XL Overexpression in motoneurons

Autor: Ana Garcera, Stefka Mincheva, Myriam Gou-Fabregas, Víctor Caraballo-Miralles, Jerònia Lladó, Joan X. Comella, Rosa M. Soler

Publikováno v: Neurobiology of Disease, Vol 42, Iss 3, Pp 415-426 (2011)

Spinal muscular atrophy (SMA) is a motoneuron disorder characterized by deletions or specific mutations in the Survival Motor Neuron gene (SMN). SMN is ubiquitously expressed and has a general role in the assembly of small nuclear ribonucleoprotein (

Externí odkaz: https://doaj.org/article/cca0e6b8c4a44401a071870815f597f3

Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1

Autor: Federico Portillo, Antonio Campos-Caro, Rosa M. Soler, Germán Domínguez-Vías, Noura Issaoui, Laura Gómez-Pérez, David González-Forero, Bernardo Moreno-López, Ángela Gento-Caro, Guillermo Rodríguez-Bey, Victoria García-Morales, Ana Garcera

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-23 (2019)
Nature Communications(2019) 10:3784
RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz
instname
Recercat. Dipósit de la Recerca de Catalunya
Repositorio Abierto de la UdL
Universitad de Lleida

Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological diseases. The adaptor protein p11, and background potassium channel TASK1, have overlapping

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69078e0d9b0cb67d932bea4d3bc45767
https://doi.org/10.1038/s41467-019-11637-4