Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ana Gallego-Lleyda"'
Publikováno v:
Cancers, Vol 11, Iss 4, p 444 (2019)
(TNF)-related apoptosis-inducing ligand (TRAIL) is able to activate the extrinsic apoptotic pathway upon binding to DR4/TRAIL-R1 and/or DR5/TRAIL-R2 receptors. Structural data indicate that TRAIL functions as a trimer that can engage three receptor m
Externí odkaz:
https://doaj.org/article/7d90e6e748904a10999ac9b69f8954bd
Publikováno v:
Cells, Vol 8, Iss 2, p 154 (2019)
T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivati
Externí odkaz:
https://doaj.org/article/dddc231743294cc083e4d2ad3a1eb4d0
Publikováno v:
Cancers, Vol 11, Iss 4, p 444 (2019)
Cancers
Cancers
(TNF)-related apoptosis-inducing ligand (TRAIL) is able to activate the extrinsic apoptotic pathway upon binding to DR4/TRAIL-R1 and/or DR5/TRAIL-R2 receptors. Structural data indicate that TRAIL functions as a trimer that can engage three receptor m
Publikováno v:
Cells, Vol 8, Iss 2, p 154 (2019)
Cells
Cells
T-cell mediated immune responses should be regulated to avoid the development of autoimmune or chronic inflammatory diseases. Several mechanisms have been described to regulate this process, namely death of overactivated T cells by cytokine deprivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9fdf03f1f6effb16f988dc2cebf7f8
https://doi.org/10.20944/preprints201812.0346.v1
https://doi.org/10.20944/preprints201812.0346.v1
Autor:
Miguel Martinez-Ara, Ana Gallego-Lleyda, Javier Plou, Diego de Miguel, Alberto Anel, Luis Martínez-Lostao
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Cancers
Volume 11
Issue 12
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Cancers
Volume 11
Issue 12
Although TRAIL (TNF-related apoptosis-inducing ligand, also known as Apo2L) was described as capable of inducing apoptosis in transformed cells while sparing normal cells, limited results obtained in clinical trials has limited its use as an anti-tum
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1449
International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1449
Sarcomas are rare and heterogeneous cancers classically associated with a poor outcome. Sarcomas are 1% of the cancer but recent estimations indicate that sarcomas account for 2% of the estimated cancer-related deaths. Traditional treatment with surg
Autor:
Hermann Josef Thierse, Manuel Sanclemente, Ana Gallego-Lleyda, Luis Martínez-Lostao, Alberto Anel, Lisa Dietz, Alberto Bosque, María A. Alava, Javier Naval, María Iturralde
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Oncotarget
instname
Oncotarget
// Alberto Bosque 1, 4, * , Lisa Dietz 2, * , Ana Gallego-Lleyda 1, * , Manuel Sanclemente 1 , Maria Iturralde 1 , Javier Naval 1 , Maria Angeles Alava 1 , Luis Martinez-Lostao 1, 3, 5, # , Hermann-Josef Thierse 2, # , Alberto Anel 1, # 1 Departament
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57056c969a672d7f47445cf011d7f07
http://zaguan.unizar.es/record/48445
http://zaguan.unizar.es/record/48445
Autor:
Luis J. Fernández, Jose M. Ayuso, Vidal Jarauta, Alberto Anel, Luis Martínez-Lostao, Blanca Conde, Diego de Miguel, Ana Gallego-Lleyda, Ignacio Ochoa, Isabel Marzo, Dolores Pejenaute-Ochoa
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
instname
During the last years, a great effort has been invested into developing new TRAIL formulations with increased bioactivity, trying to overcome the resistance to conventional soluble TRAIL (sTRAIL) exhibited by many primary tumours. In our group, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a34e29376e74d0b95616734937ecda
http://zaguan.unizar.es/record/70347
http://zaguan.unizar.es/record/70347
Autor:
C. Rodriguez-Vigil, Ana Gallego-Lleyda, Isabel Marzo, D. De Miguel, Patricia Galán-Malo, Alberto Anel, Luis Martínez-Lostao
Publikováno v:
Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 17(8)
Human Apo2-Ligand/TRAIL secreted by natural killer cells and cytotoxic T lymphocytes plays an important role immunosurveillance controlling tumor growth and metastasis. Moreover, the fact that Apo2L/TRAIL is capable of inducing cell death in tumor ce
Autor:
Blanca Conde, Ana Gallego-Lleyda, Ignacio Ochoa, Luis Martínez-Lostao, Alberto Anel, Jose M. Ayuso, Diego de Miguel, Luis J. Fernández, Aleksandra Pawlak
Publikováno v:
Recent patents on anti-cancer drug discovery. 11(2)
Background: Apo2-ligand/TRAIL, a member of the TNF cytokine superfamily capable of inducing apoptosis on tumor cells while sparing normal cells, is a promising anti-tumor agent. However, about 50% of human cancer are TRAIL resistant. Consequently, fu