Two variants in the fibulin2 gene are associated with lower systolic blood pressure and decreased risk of hypertension.

Autor: Joan-Carles Vallvé, Noemí Serra, Guillermo Zalba, Ana Fortuño, Oscar Beloqui, Raimon Ferre, Josep Ribalta, Lluís Masana

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e43051 (2012)

Arterial stiffness is an important factor in hypertension. Fibulin 2 is an extracellular matrix scaffold protein involved in arterial stiffness and, hence, the fibulin 2 (FBLN2) gene may be a candidate for hypertension susceptibility. 4 single nucleo

Externí odkaz: https://doaj.org/article/318f2a96b2874a3698e33f53fdbee6e1

Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma

Autor: Jorge Abad, Mónica González, Amaia Urrutia, Lorena Comeche, Antonio Cruz-Medina, Luis Javier del Pozo, Maria Jose Selma-Ferrer, Sonia Segura, Erika Miranda, Santiago Antonio Juarros, Francisco Campos-Rodriguez, Jaime Corral, Pilar Manchado, Esther de Eusebio, Daniela Cullen, Nuria Reyes-Nuñez, Mónica de la Peña, Teresa Gomez-Garcia, Cristian Perna, Isaac Almendros, Blanca de Unamuno, Olga Mediano, Eusebi Chiner, Miguel Ángel Martínez-García, Maider Mateos, Aida Muñoz, A. Martorell, Ferran Barbé, Bienvenido Barreiro, Jose Antonio Aramburu, Mercedes Mayos, Eva Arias, Josep M. Montserrat, David Gozal, Cristina Carrera, Valentin Cabriada, Verónica Velasco, Adam Boada, Ana Fortuño, Rosa M. Martí, Ana Mozos, Joan Dalmau, Isabel Betlloch, Ramon Farré, Felipe Aizpuru, Manuel Sánchez de la Torre, Irene Cano, Juan F. Masa, Eduardo Alcaraz, Pedro Landete, Zully Vásquez, Jose Gardeazabal, Monica Llombart, Cristina Navarro, Paula Rodriguez, Erica Riveiro-Falkenbach, N Curcó, Eduardo Nagore, Luis Hernández, Julian Caballero, Martina Alés, Raquel Catalá, M. Angeles Gonzalez, José Luis Rodríguez-Peralto, Amalia Pérez-Gil, José Bañuls, Olga Cantalejo, Manuel Moragon, Antonio Azón, María Pérez-Crespo, Cristina Martínez González, Andrea Crespo, Alberto García-Ortega, Nuria Grau, M. Fernanda Troncoso, Jesús Martín, Javier Gómez de Terreros, Alicia Sanchez de la Torre, Pablo Ortiz, María Somoza, Esther Pastor, Manuel Formigón

Publikováno v: Chest. 154:1348-1358

Background Sleep-disordered breathing (SDB) has been associated with a greater incidence and mortality of cancer, although such findings are inconsistent. However, no large studies are currently available to investigate this association in patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26c6007a1f343ece094926d56173ceb0
https://doi.org/10.1016/j.chest.2018.07.015

Leptin Induces Oxidative Stress Through Activation of NADPH Oxidase in Renal Tubular Cells: Antioxidant Effect of L-Carnitine

Autor: Alfonso Mate, José L. Miguel-Carrasco, Carmen Vázquez, Sonia Zambrano, Rocío Salsoso, Ana Fortuño, Antonio J. Blanca, Elisa Revilla, María V. Ruiz-Armenta

Publikováno v: Journal of Cellular Biochemistry. 117:2281-2288

Leptin is a protein involved in the regulation of food intake and in the immune and inflammatory responses, among other functions. Evidences demonstrate that obesity is directly associated with high levels of leptin, suggesting that leptin may direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ecc5946bc62cd21a1ebf281f9531a5a
https://doi.org/10.1002/jcb.25526

Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites

Autor: Gorka San José, Ana Fortuño, Javier Beaumont, Javier Díez, José Luis Miguel-Carrasco, Guillermo Zalba, Susana Ravassa, María U. Moreno, Arantxa González, Begoña López

Publikováno v: Scientific Reports
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Excessive myocardial collagen deposition and cross-linking (CCL), a process regulated by lysyl oxidase (LOX), determines left ventricular (LV) stiffness and dysfunction. The angiotensin II antagonist losartan, metabolized to the EXP3179 and EXP3174 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c8b0f38af708cc0eb1f6ce6b16ff9e
https://doi.org/10.1038/srep41865

A Synthetic Peptide from Transforming Growth Factor-β1Type III Receptor Inhibits NADPH Oxidase and Prevents Oxidative Stress in the Kidney of Spontaneously Hypertensive Rats

Autor: Javier Dotor, Ana Fortuño, Francisco Borrás-Cuesta, Begoña López, Ana Baltanás, Javier Díez, Guillermo Zalba, Arantxa González, José L. Miguel-Carrasco, María U. Moreno, Gorka San José, Carolina Cebrián

Publikováno v: Antioxidants & Redox Signaling. 19:1607-1618

Aims: The NADPH oxidases constitute a major source of superoxide anion (·O2−) in hypertension. Several studies suggest an important role of NADPH oxidases in different effects mediated by transforming growth factor-β1 (TGF-β1). We investigated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12434351f2f5be1d44c555ca06f28a46
https://doi.org/10.1089/ars.2012.4653