Výsledky vyhledávání - "Ana Flávia Borsoi"

Akademický článek

Ultrasound-Assisted Synthesis of 4-Alkoxy-2-methylquinolines: An Efficient Method toward Antitubercular Drug Candidates

Autor: Ana Flávia Borsoi, Josiane Delgado Paz, Kenia Pissinate, Raoní Scheibler Rambo, Víctor Zajaczkowski Pestana, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado

Publikováno v: Molecules, Vol 26, Iss 5, p 1215 (2021)

Tuberculosis (TB) has been described as a global health crisis since the second half of the 1990s. Mycobacterium tuberculosis (Mtb), the etiologic agent of TB in humans, is a very successful pathogen, being the main cause of death in the population a

Externí odkaz: https://doaj.org/article/c035c06d4887429eb7100e70fcad1573

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Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments

Autor: Talita Freitas de Freitas, Candida Deves Roth, Bruno Lopes Abbadi, Fernanda Souza Macchi Hopf, Marcia Alberton Perelló, Alexia de Matos Czeczot, Eduardo Vieira de Souza, Ana Flávia Borsoi, Pablo Machado, Cristiano Valim Bizarro, Luiz Augusto Basso, Luis Fernando Saraiva Macedo Timmers

Publikováno v: Journal of computer-aided molecular design.

Tuberculosis (TB) is one of the main causes of death from a single pathological agent, Mycobacterium tuberculosis (Mtb). In addition, the emergence of drug-resistant TB strains has exacerbated even further the treatment outcome of TB patients. It is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1930acb0b3493be95dd9a1710dd85e10
https://pubmed.ncbi.nlm.nih.gov/36547753

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Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties

Publikováno v: ACS medicinal chemistry letters. 13(8)

Using cycloalkyl and electron-donating groups to decrease the carbonyl electrophilicity, a novel series of 2-(quinoline-4-yloxy)acetamides was synthesized and evaluated as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a7a635d9e1c691e060f2965ac3dbf0
https://pubmed.ncbi.nlm.nih.gov/35978694

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Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation

Publikováno v: European Journal of Medicinal Chemistry. 245:114908

Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ddf8b5254d536a5b68e70bfefd03c7
https://doi.org/10.1016/j.ejmech.2022.114908

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Design, synthesis, and evaluation of new 2-(quinoline-4-yloxy)acetamide-based antituberculosis agents

Autor: Josiane Delgado Paz, Kenia Pissinate, Nathalia D. M. Sperotto, Miguel Viveiros, Ana Flávia Borsoi, Raoní S. Rambo, Luiz Augusto Basso, Pablo Machado, Diana Machado, Alessandro da Silva Ramos, Cristiano Valim Bizarro, Fernanda Souza Macchi, Bruno Lopes Abbadi

Publikováno v: European journal of medicinal chemistry. 192

Using a classical molecular simplification approach, a series of 36 quinolines were synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (M. tuberculosis) growth. Structure–activity relationship (SAR) studies leaded to pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4bf499a8e616bc67bdcd963c4433a7
https://pubmed.ncbi.nlm.nih.gov/32113048

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Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts

Autor: Candida Deves Roth, Marcia Alberton Perelló, Carla Denise Bonan, Luiz Augusto Basso, Adilio da Silva Dadda, Jayne Torres de Sousa, Débora Dreher Nabinger, Rodrigo Braccini Madeira da Silva, Jaqueline Nascimento Picada, Valnês S. Rodrigues-Junior, Stefani Altenhofen, Pablo Machado, Cristiano Valim Bizarro, Raquel D.S. Freitas, Ana Flávia Borsoi, Nathalia D. M. Sperotto, Deise Nascimento de Freitas, Ana Paula de Souza

Publikováno v: Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111672-(2021)

Human thymidine phosphorylase (hTP) is overexpressed in several solid tumors and is commonly associated with aggressiveness and unfavorable prognosis. 6-(((1,3-Dihydroxypropan-2-yl)amino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione (CPBMF-223) is a nonc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9a881cfe515a5c1e01f2e201f1ffd9
https://doi.org/10.1016/j.biopha.2021.111672

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Ultrasound-Assisted Synthesis of 4-Alkoxy-2-methylquinolines: An Efficient Method toward Antitubercular Drug Candidates

Autor: Pablo Machado, Josiane Delgado Paz, Kenia Pissinate, Cristiano Valim Bizarro, Luiz Augusto Basso, Ana Flávia Borsoi, Raoní S. Rambo, Víctor Zajaczkowski Pestana

Publikováno v: Molecules
Volume 26
Issue 5
Molecules, Vol 26, Iss 1215, p 1215 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73744b9c58bcf5e482de0aba26869d0b
https://doi.org/10.3390/molecules26051215

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1H-Benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones: Design, synthesis and antitubercular activity

Autor: Valnês S. Rodrigues-Junior, Stefani Altenhofen, Fernanda Teixeira Subtil, Anne Drumond Villela, Luiz Augusto Basso, Diógenes Santiago Santos, Cristiano Valim Bizarro, Nathalia D. M. Sperotto, Fernanda Souza Macchi, Carla Denise Bonan, Pablo Machado, Débora Dreher Nabinger, Talita Freitas de Freitas, Adilio da Silva Dadda, Ana Paula Erhart Rauber, Kenia Pissinate, Ana Flávia Borsoi, Bruno Lopes Abbadi

Publikováno v: European journal of medicinal chemistry. 155

Using a classical hybridization approach, a series of 1H-benzo[d]imidazoles and 3,4-dihydroquinazolin-4-ones were synthesized (39 examples) and evaluated as inhibitors of Mycobacterium tuberculosis growth. Chemical modification studies yielded potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aba169829a6c1d556426215abd6b544
https://pubmed.ncbi.nlm.nih.gov/29885576

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Ultrasound-assisted synthesis of 2-amino-1,3,4-oxadiazoles through NBS-mediated oxidative cyclization of semicarbazones

Autor: Diógenes Santiago Santos, Kenia Pissinate, Ana Flávia Borsoi, Luiz Augusto Basso, Mateus Emanuel Coldeira, Pablo Machado, Fernanda Souza Macchi

A ultrasound-assisted oxidative cyclization of semicarbazones using N-bromosuccinimide in the presence of sodium acetate was established providing efficient and rapid access to a variety of 2-amino-1,3,4-oxadiazoles. Moreover, the new synthetic proto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d2add55d9c66a6a0bfe69e2f083f92

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