Transcriptomic analysis of patients with immune thrombocytopenia treated with eltrombopag

Autor: Jesús María Hernández-Sánchez, José María Bastida, Diego Alonso-López, Rocío Benito, José Ramón González-Porras, Javier De Las Rivas, Jesús María Hernández Rivas, Ana Eugenia Rodríguez-Vicente

Publikováno v: Platelets, Vol 31, Iss 8, Pp 993-1000 (2020)

In the last years, the use of thrombopoietin receptor agonists (TPO-RA), eltrombopag and romiplostim, has improved the management of immune thrombocytopenia (ITP). Moreover, eltrombopag is also active in patients with aplastic anemia and myelodysplas

Externí odkaz: https://doaj.org/article/1d058db6f211498e816e3ec8ee6e8695

A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia.

Autor: José Ángel Hernández, María Hernández-Sánchez, Ana Eugenia Rodríguez-Vicente, Vera Grossmann, Rosa Collado, Cecilia Heras, Anna Puiggros, Ana África Martín, Noemí Puig, Rocío Benito, Cristina Robledo, Julio Delgado, Teresa González, José Antonio Queizán, Josefina Galende, Ignacio de la Fuente, Guillermo Martín-Núñez, José María Alonso, Pau Abrisqueta, Elisa Luño, Isabel Marugán, Isabel González-Gascón, Francesc Bosch, Alexander Kohlmann, Marcos González, Blanca Espinet, Jesús María Hernández-Rivas, Grupo Cooperativo Español de Citogenética Hematológica (GCECGH) and Grupo Español de Leucemia Linfática Crónica (GELLC)

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143073 (2015)

To analyze the impact of the 11q deleted (11q-) cells in CLL patients on the time to first therapy (TFT) and overall survival (OS), 2,493 patients with CLL were studied. 242 patients (9.7%) had 11q-. Fluorescence in situ hybridization (FISH) studies

Externí odkaz: https://doaj.org/article/6572f0a44cbe4c42af91d0ad5ea4aa40

Genome-wide transcriptomics leads to the identification of deregulated genes after deferasirox therapy in low-risk MDS patients

Autor: Jesús María Hernández-Rivas, Diego Alonso López, Eva Lumbreras, María Abáigar, Beatriz Arrizabalaga, Ana A. Martín, Teresa González, María Díez-Campelo, Jesús María Hernández Sánchez, Sara Erquiaga, Mónica del Rey, Raquel de Paz, Ana Eugenia Rodríguez Vicente

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The iron chelator deferasirox is widely used in patients with iron overload. Patients with low-grade myelodysplastic syndromes (MDS) get transfusion dependency and need to be treated with deferasirox to avoid iron overload. Moreover, in some patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b499b4403f28c764c71485813230cd2
https://doi.org/10.1038/s41397-020-0154-5

Dissecting the role of TP53 alterations in del(11q) chronic lymphocytic leukemia

Autor: Mónica del Rey, Jesús María Hernández-Rivas, Rocío Benito, Alfonso García de Coca, Ana‐Belén Herrero, Araceli Rubio-Martinez, Julio Dávila‐Valls, Helen Parker, Jonathan C. Strefford, Ana-Eugenia Rodríguez-Vicente, María Hernández-Sánchez, José‐Luis Ordóñez, Sandra Santos-Mínguez, Miguel Quijada-Álamo, Teresa González, J.M. Hernández-Sánchez, Claudia Pérez-Carretero, Jose Angel Hernandez-Rivas, Marta Martín-Izquierdo

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 2, Pp n/a-n/a (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Clinical and Translational Medicine

© 2021 The Authors.
[Background]: Several genetic alterations have been identified as driver events in chronic lymphocytic leukemia (CLL) pathogenesis and oncogenic evolution. Concurrent driver alterations usually coexist within the same tumora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74173b5a016d270ffc596902bd9b58c
https://doi.org/10.1002/ctm2.304

The International Prognostic Index for Patients with Chronic Lymphocytic Leukemia Has the Higher Value in Predicting Overall Outcome Compared with the Barcelona-Brno Biomarkers Only Prognostic Model and the MD Anderson Cancer Center Prognostic Index

Autor: Jesús María Hernández-Rivas, Ana-Eugenia Rodríguez-Vicente, Cecilia Heras, María Hernández-Sánchez, Isabel González-Gascón y Marín, María Poza-Santaella, José-Ángel Hernández, Maria‐Stefania Infante, Carolina Muñoz-Novas, Karen Marín, Maria Angeles Foncillas

Publikováno v: BioMed Research International
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
BioMed Research International, Vol 2018 (2018)
Digital.CSIC. Repositorio Institucional del CSIC
instname

In recent years, new prognostic indexes (PIs) for chronic lymphocytic leukemia (CLL), which include clinical, biological, and genetic variables, have been validated, highlighting the MD Anderson Cancer Center prognostic index (MDACC PI), the CLL-inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c152e182d66f5c01305f80a15909a17
https://doi.org/10.1155/2018/9506979