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Akademický článek

A Porphyromonas gingivalis hypothetical protein controlled by the type I-C CRISPR-Cas system is a novel adhesin important in virulence

Autor: Muhammad Irfan, Jose Solbiati, Ana Duran-Pinedo, Fernanda Godoy Rocha, Frank C. Gibson, Jorge Frias-Lopez

Publikováno v: mSystems, Vol 9, Iss 3 (2024)

ABSTRACTThe ability of many human pathogens to infect requires their ability to adhere to the host surfaces as a first step in the process. Porphyromonas gingivalis, a keystone oral pathogen, uses adhesins to adhere to the surface of the gingival epi

Externí odkaz: https://doaj.org/article/5998851a22c445059b0f2a903a77390e

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Akademický článek

Long-term dynamics of the human oral microbiome during clinical disease progression

Autor: Ana Duran-Pinedo, Jose Solbiati, Flavia Teles, Ricardo Teles, Yanping Zang, Jorge Frias-Lopez

Publikováno v: BMC Biology, Vol 19, Iss 1, Pp 1-17 (2021)

Abstract Background Oral microbiome dysbiosis is linked to overt inflammation of tooth-supporting tissues, leading to periodontitis, an oral condition that can cause tooth and bone loss. Microbiome dysbiosis has been described as a disruption in the

Externí odkaz: https://doaj.org/article/abd635cab3a44a2c83eb4ba6f7cbec01

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Akademický článek

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Akademický článek

The three NADH dehydrogenases of Pseudomonas aeruginosa: Their roles in energy metabolism and links to virulence.

Autor: Teri N Hreha, Sara Foreman, Ana Duran-Pinedo, Andrew R Morris, Patricia Diaz-Rodriguez, J Andrew Jones, Kristina Ferrara, Anais Bourges, Lauren Rodriguez, Mattheos A G Koffas, Mariah Hahn, Alan R Hauser, Blanca Barquera

Publikováno v: PLoS ONE, Vol 16, Iss 2, p e0244142 (2021)

Pseudomonas aeruginosa is a ubiquitous opportunistic pathogen which relies on a highly adaptable metabolism to achieve broad pathogenesis. In one example of this flexibility, to catalyze the NADH:quinone oxidoreductase step of the respiratory chain,

Externí odkaz: https://doaj.org/article/4afa726bb14345f19cd187310e535bd5

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Akademický článek

Virulence of the Pathogen Porphyromonas gingivalis Is Controlled by the CRISPR-Cas Protein Cas3

Autor: Jose Solbiati, Ana Duran-Pinedo, Fernanda Godoy Rocha, Frank C. Gibson, Jorge Frias-Lopez

Publikováno v: mSystems, Vol 5, Iss 5 (2020)

ABSTRACT The CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system is a unique genomic entity that provides prokaryotic cells with adaptive and heritable immunity. Initial studies identified CRISPRs as central elements used by

Externí odkaz: https://doaj.org/article/7bfecfb23ba64cbfa3d4bda9e35cc9bb

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