Covalent Hemin/G4 complex-linked sandwich bioassay on magnetic beads for femtomolar HER-2/neu detection in human serum via direct electrocatalytic reduction of oxygen

Autor: Ana Díaz-Fernández, Elena E. Ferapontova

Publikováno v: Díaz-Fernández, A & Ferapontova, E E 2022, ' Covalent Hemin/G4 complex-linked sandwich bioassay on magnetic beads for femtomolar HER-2/neu detection in human serum via direct electrocatalytic reduction of oxygen ', Analytica Chimica Acta, vol. 1219, 340049 . https://doi.org/10.1016/j.aca.2022.340049

Liquid biopsy assays for tumour biomarkers circulating in blood are perspective non-invasive tools for cancer diagnosis and treatment monitoring. Here, we suggest a simple, 1 h long electrochemical DNAzyme-linked aptamer- and immuno-sandwich magnetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88689b7d0ce57dd05c5e29dbc4f3c75e
https://pubmed.ncbi.nlm.nih.gov/35715131

Ultrasensitive disposable apatasensor for reagentless electrocatalytic detection of thrombin: An O

Autor: Lucía, Gómez-Arconada, Ana, Díaz-Fernández, Elena E, Ferapontova

Publikováno v: Talanta. 245

Serine protease thrombin is a strong neurotoxin produced by the injured brain and an Alzheimer's disease biomarker. To address its point-of-care testing (POCT), we adapted the O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e3bf3cd3f34c95958a721527c9eb459
https://pubmed.ncbi.nlm.nih.gov/35413630

Catching the Sugars: Electrochemical Aptasensors for the Detection of Cancer-Related Glycosylation Changes in Prostate-Specific Antigen

Autor: Pedro Estrela, María Jesús Lobo-Castañón, Noemí de-los-Santos-Álvarez, Rebeca Miranda-Castro, Ana Díaz-Fernández

Publikováno v: Diaz-Fernandez, A, Miranda-Castro, R, Estrela, P, de los Santos Alvarez, N & Lobo Castanon, M J 2020, ' Catching the Sugars: Electrochemical Aptasensors for the Detection of Cancer-Related Glycosylation Changes in Prostate-Specific Antigen ', Proceedings — Open Access Journal, vol. 60, no. 1, 47 . https://doi.org/10.3390/IECB2020-07023

Prostate-specific Antigen (PSA) is the biomarker that is used for prostate cancer (PCa) detection, although its lack of specificity results in a high rate of false-positives and many unnecessary biopsies. Therefore, there is a need for more specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc927b340184e0c47c425778d9c6eb0f
https://purehost.bath.ac.uk/ws/files/214735165/proceedings_60_00047_1_.pdf

Aptamers targeting protein-specific glycosylation in tumor biomarkers: general selection, characterization and structural modeling

Autor: Dimas Suárez, Natalia Díaz, Noemí de-los-Santos-Álvarez, Ana Díaz-Fernández, Rebeca Miranda-Castro, M. Jesús Lobo-Castañón

Publikováno v: Chemical Science
RUO: Repositorio Institucional de la Universidad de Oviedo
Universidad de Oviedo (UNIOVI)
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

Detecting specific protein glycoforms is attracting particular attention due to its potential to improve the performance of current cancer biomarkers. Although natural receptors such as lectins and antibodies have served as powerful tools for the det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::278fcf63052839823cd54740bbac01f3
http://hdl.handle.net/10651/57744

Post-translational modifications in tumor biomarkers: the next challenge for aptamers?

Autor: María Jesús Lobo-Castañón, Ana Díaz-Fernández, Noemí de-los-Santos-Álvarez, Rebeca Miranda-Castro

Publikováno v: Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

Advances in proteomics have fueled the search for novel cancer biomarkers with higher selectivity. Differential expression of low abundant proteins has been the usual way of finding those biomarkers. The existence of a selective receptor for each bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651d2dd3d2e1ae4b8d136a361cd47937
https://pubmed.ncbi.nlm.nih.gov/29353432