Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ana Cehovin"'
Autor:
Lenka Stejskal, Angela Thistlethwaite, Fidel Ramirez-Bencomo, Smruti Rashmi, Odile Harrison, Ian M. Feavers, Martin C. J. Maiden, Ann Jerse, Grace Barnes, Oscar Chirro, James Chemweno, Eunice Nduati, Ana Cehovin, Christoph Tang, Eduard J. Sanders, Jeremy P. Derrick
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Development of a vaccine against gonorrhoea is a global priority, driven by the rise in antibiotic resistance. Although Neisseria gonorrhoeae (Ng) infection does not induce substantial protective immunity, highly exposed individuals may deve
Externí odkaz:
https://doaj.org/article/cd99a63b581e43b3a4aeb85b342e49be
Publikováno v:
mSphere, Vol 8, Iss 6 (2023)
ABSTRACTNeisseria gonorrhoeae causes sexually transmitted infection (STI) gonorrhoea and is on the WHO critical list due to increasing antimicrobial resistance (AMR). The bacterium can carry a conjugative plasmid, pConj, which prevents the use of tet
Externí odkaz:
https://doaj.org/article/bcc701fab6974d8299d2c069174a4a61
Publikováno v:
PLoS Genetics, Vol 19, Iss 5, p e1010743 (2023)
Plasmids are diverse extrachromosomal elements significantly that contribute to interspecies dissemination of antimicrobial resistance (AMR) genes. However, within clinically important bacteria, plasmids can exhibit unexpected narrow host ranges, a p
Externí odkaz:
https://doaj.org/article/40f3ec4adcdd4292ab94a0c56d1e67ac
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The bacterium Neisseria meningitidis causes life-threatening meningitis and sepsis. Here, Muir et al. construct a complete collection of defined mutants in protein-coding genes of this organism, which they use to identify its essential genome and to
Externí odkaz:
https://doaj.org/article/d95231864c5047f889a4063e8d65f361
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004014 (2013)
Natural transformation is the widespread biological process by which "competent" bacteria take up free DNA, incorporate it into their genomes, and become genetically altered or "transformed". To curb often deleterious transformation by foreign DNA, s
Externí odkaz:
https://doaj.org/article/042852504f18431baa5dcd62913c8fa3
Publikováno v:
Microbiology. 168
Neisseria gonorrhoeae , the gonococcus, is a pathogen of major public health concern, but sophisticated approaches to gene manipulation are limited for this species. For example, there are few methods for generating markerless mutations, which allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a92302abebec3f99243c48386ae35594
https://doi.org/10.1099/mic.0.001201
https://doi.org/10.1099/mic.0.001201
Publikováno v:
Access Microbiology. 4
Neisseria gonorrhoeae (the gonococcus) is the causative agent of the sexually-transmitted infection gonorrhoea, and has developed resistance to all classes of antimicrobials. In gonococci, plasmids can mediate high-level antimicrobial resistance (AMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adb4a0556f64ed483344061393ccaf8b
https://doi.org/10.1099/acmi.ac2021.po0017
https://doi.org/10.1099/acmi.ac2021.po0017
Autor:
Christoph M. Tang, Odile B. Harrison, Ana Cehovin, Martin C. J. Maiden, Paola Massari, Keith A. Jolley, Caroline A. Genco, Jessica Skett
Publikováno v:
The Journal of Infectious Diseases. 222:1816-1825
Background Gonorrhea, caused by the bacterium Neisseria gonorrhoeae, is a globally prevalent sexually transmitted infection. The dynamics of gonococcal population biology have been poorly defined due to a lack of resolution in strain typing methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50317b18231ac8485d244932d8fa472b
https://doi.org/10.1093/infdis/jiaa002
https://doi.org/10.1093/infdis/jiaa002
One of the great challenges in biology is to determine the function of millions of genes of unknown function. Even in model bacterial species, there is a sizeable proportion of such genes, which has fundamental and practical consequences. Here, we co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d511f3e31a28882d0027fb8a462fb17
https://doi.org/10.1101/2020.08.12.247981
https://doi.org/10.1101/2020.08.12.247981
Publikováno v:
The Journal of Infectious Diseases
Plasmids are vehicles for horizontal gene transfer between bacteria, and in Neisseria gonorrhoeae plasmids can mediate high-level antimicrobial resistance (AMR). Using genomic and phylogenetic analyses, we show that plasmids are widespread in a colle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb1033b64d44cc23aa80aaf733ca25e
https://pubmed.ncbi.nlm.nih.gov/32163574
https://pubmed.ncbi.nlm.nih.gov/32163574