On the safety and effectiveness of COVID-19 vaccines, certainties and uncertainties

Autor: Ana Cecilia Amado Xavier de Oliveira, Isabella Fernandes Delgado, Francisco José Roma Paumgartten

Publikováno v: Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, Vol 9 (2021)

Introduction: The COVID-19 vaccines in use (inactivaded virus, encapsulated m-RNA, non-replicating adenovirus-vectored DNA) were clinically tested in randomized placebocontrolled phase-3 studies. Objective: To address certainties and uncertainties ab

Externí odkaz: https://doaj.org/article/fc01bc3f449a4cc99edb16d993fa8067

Drug repurposing clinical trials in the search for life-saving COVID-19 therapies; research targets and methodological and ethical issues

Autor: Francisco José Roma Paumgartten, Isabella Fernandes Delgado, Luciana da Rocha Pitta, Ana Cecilia Amado Xavier de Oliveira

Publikováno v: Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, Vol 8, Iss 2 (2020)

Introduction: So far, there is no vaccine, nor are there effective drugs to treat COVID-19, an emerging viral respiratory infection deadlier than influenza. Objective: To take a snapshot picture of planned and ongoing clinical research addressing dru

Externí odkaz: https://doaj.org/article/7ffba210b49b46ceab8cb164ce609341

Safety and efficacy of fenproporex for obesity treatment: a systematic review

Autor: Francisco José Roma Paumgartten, Sabrina Schaaf Teixeira Costa Pereira, Ana Cecilia Amado Xavier de Oliveira

Publikováno v: Revista de Saúde Pública, Vol 50, Iss 0 (2016)

ABSTRACT OBJECTIVE To evaluate clinical evidence on the safety and efficacy of fenproporex for treating obesity. METHODS MEDLINE, LILACS and Cochrane Controlled Trials Register were searched as well as references cited by articles and relevant docume

Externí odkaz: https://doaj.org/article/caeb68f419154b1db47cc3d64d50112b

Considerações éticas sobre estudos de vacina controlada com placebo em gestantes

Autor: Ana Cecilia Amado Xavier de Oliveira, Francisco José Roma Paumgartten

Publikováno v: Revista Bioética, Volume: 31, Article number: e3205PT, Published: 08 MAY 2023

Placebo use in clinical trials, whenever a proven effective treatment exists, is one of the most debated topics in contemporary research ethics. This article addresses the ethical framework for placebo use in clinical trials assessing vaccine efficac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea86222344200d0518cb74889d991e9
https://doi.org/10.1590/1983-803420233205pt

Off label, compassionate and irrational use of medicines in Covid-19 pandemic, health consequences and ethical issues

Autor: Francisco José Roma Paumgartten, Ana Cecilia Amado Xavier de Oliveira

Publikováno v: Ciência & Saúde Coletiva, Vol 25, Iss 9, Pp 3413-3419 (2020)
Ciência & Saúde Coletiva v.25 n.9 2020
Ciência & Saúde Coletiva
Associação Brasileira de Saúde Coletiva (ABRASCO)
instacron:ABRASCO

When Covid-19 emerged in December last year, there was no vaccine nor was there specific effective treatment for this fast-spreading and life-threatening viral respiratory infection. Clinical trials were planned and are in progress to investigate whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ba828ea95f397237ba742f86244baa
https://doi.org/10.1590/1413-81232020259.16792020