Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Ana Carolina B. da C. Rodrigues"'
1
Akademický článek
Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis
Autor: Ingrid R. S. B. Dias, Rafaela G. A. Costa, Ana Carolina B. da C. Rodrigues, Suellen L. R. Silva, Maiara de S. Oliveira, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Lauren V. Cairns, Ken I. Mills, Daniel P. Bezerra
Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Acute myeloid leukaemia (AML) is a lethal bone marrow neoplasm caused by genetic alterations in blood cell progenitors. Leukaemic stem cells (LSCs) are responsible for the development of AML, drug resistance and relapse. Bithionol is an old
Externí odkaz: https://doaj.org/article/8802be9e97fa4560b21e60e2788a7cd9
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2
Akademický článek
Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells
Autor: Suellen L. R. Silva, Ingrid R. S. B. Dias, Ana Carolina B. da C. Rodrigues, Rafaela G. A. Costa, Maiara de S. Oliveira, Gabriela A. da C. Barbosa, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Nainita Roy, Christopher Y. Park, Daniel P. Bezerra
Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote the development and progression of AML, and eradication of LSCs is critical for effe
Externí odkaz: https://doaj.org/article/07013829e0064a6b9da30cd661ecddb5
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3
Akademický článek
Piplartine eliminates CD34 + AML stem/progenitor cells by inducing oxidative stress and suppressing NF-κB signalling
Autor: Ana Carolina B. da C. Rodrigues, Suellen L. R. Silva, Ingrid R. S. B. Dias, Rafaela G. A. Costa, Maiara de S. Oliveira, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Emily M. Johnson, Cristina Pina, Daniel P. Bezerra
Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Acute myeloid leukaemia (AML) is a haematological malignancy characterised by the accumulation of transformed myeloid progenitors in the bone marrow. Piplartine (PL), also known as piperlongumine, is a pro-oxidant small molecule extracted fr
Externí odkaz: https://doaj.org/article/45153271df08471280ba301d8a84973f
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4
Akademický článek
Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells
Autor: Rafaela G.A. Costa, Suellen L.R. Silva, Ingrid R.S.B. Dias, Maiara de S. Oliveira, Ana Carolina B. da C. Rodrigues, Rosane B. Dias, Daniel P. Bezerra
Publikováno v: Redox Biology, Vol 62, Iss , Pp 102692- (2023)
Acute myeloid leukemia (AML) is a very heterogeneous group of disorders with large differences in the percentage of immature blasts that presently are classified according to the specific mutations that trigger malignant proliferation among thousands
Externí odkaz: https://doaj.org/article/acdadc114e65461d80c3436501fba557
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5
Akademický článek
Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells
Autor: Ana Carolina B. da C. Rodrigues, Larissa M. Bomfim, Sara P. Neves, Milena B.P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Emmanoel V. Costa, Felipe M.A. da Silva, Waldireny C. Rocha, Hector H.F. Koolen, Daniel P. Bezerra
Publikováno v: Biomedicine & Pharmacotherapy, Vol 142, Iss , Pp 112034- (2021)
Acute myeloid leukemia (AML) is the most lethal form of leukemia. Standard anti-AML treatment remains almost unchanged for decades. Tingenone (TG) and 22-hydroxytingenone (22-HTG) are quinonemethide triterpenes found in the Amazonian plant Salacia im
Externí odkaz: https://doaj.org/article/5041c20dc21d4b16a16553f51c05a97b
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6
Akademický článek
Cytotoxic Alkaloids from the Stem of Xylopia laevigata
Autor: Leociley R. A. Menezes, Cinara O. D´Sousa Costa, Ana Carolina B. da C. Rodrigues, Felipe R. do E. Santo, Angelita Nepel, Lívia M. Dutra, Felipe M. A. Silva, Milena B. P. Soares, Andersson Barison, Emmanoel V. Costa, Daniel P. Bezerra
Publikováno v: Molecules, Vol 21, Iss 7, p 890 (2016)
Xylopia laevigata (Annonaceae), known locally as “meiú” or “pindaíba”, is widely used in folk medicine in Northeastern Brazil. In the present work, we performed phytochemical analyses of the stem of X. laevigata, which led to the isolation
Externí odkaz: https://doaj.org/article/90015b59ae1841dd9e5489d6b6985803
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7
Akademický článek
ASARONE-DERIVED PHENYLPROPANOIDS AND ISOQUINOLINE-DERIVED ALKALOIDS FROM THE BARK OF Duguetia pycnastera (Annonaceae) AND THEIR CYTOTOXICITIES
Autor: César A. S. de Souza, Victória B. Nardelli, Weider H. P. Paz, Maria Lúcia B. Pinheiro, Ana Carolina B. da C. Rodrigues, Larissa M. Bomfim, Milena B. P. Soares, Daniel P. Bezerra, Jamal da S. Chaar, Hector H. F. Koolen, Felipe M. A. da Silva, Emmanoel Vilaça Costa
Publikováno v: Química Nova
The phytochemical investigation of the hexane and methanol extracts from the bark of Duguetia pycnastera Sandwith (Annonaceae) afforded seven known compounds, two asarone-derived phenylpropanoids and five isoquinoline-derived alkaloids. The asarones,
Externí odkaz: https://doaj.org/article/8adfd1e96ee342c5b0b5e126cab18ad7
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