Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ana Candalija"'
Autor:
Björn F. Vahsen, Sumedha Nalluru, Georgia R. Morgan, Lucy Farrimond, Emily Carroll, Yinyan Xu, Kaitlyn M. L. Cramb, Benazir Amein, Jakub Scaber, Antigoni Katsikoudi, Ana Candalija, Mireia Carcolé, Ruxandra Dafinca, Adrian M. Isaacs, Richard Wade-Martins, Elizabeth Gray, Martin R. Turner, Sally A. Cowley, Kevin Talbot
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia. The commonest ALS-associated genetic v
Externí odkaz:
https://doaj.org/article/3d51552885d24a2f94bd75e36ffa3438
Autor:
Björn F. Vahsen, Elizabeth Gray, Ana Candalija, Kaitlyn M. L. Cramb, Jakub Scaber, Ruxandra Dafinca, Antigoni Katsikoudi, Yinyan Xu, Lucy Farrimond, Richard Wade-Martins, William S. James, Martin R. Turner, Sally A. Cowley, Kevin Talbot
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by motor neuron degeneration with additional involvement of non-neuronal cells, in particular, microglia. In previous work, we have established protocols
Externí odkaz:
https://doaj.org/article/db218578cfca489c825f444402cee380
Autor:
Nienke Ruijter, Lya G. Soeteman-Hernández, Marie Carrière, Matthew Boyles, Polly McLean, Julia Catalán, Alberto Katsumiti, Joan Cabellos, Camilla Delpivo, Araceli Sánchez Jiménez, Ana Candalija, Isabel Rodríguez-Llopis, Socorro Vázquez-Campos, Flemming R. Cassee, Hedwig Braakhuis
Publikováno v:
Nanomaterials, Vol 13, Iss 3, p 472 (2023)
The Safe-by-Design (SbD) concept aims to facilitate the development of safer materials/products, safer production, and safer use and end-of-life by performing timely SbD interventions to reduce hazard, exposure, or both. Early hazard screening is a c
Externí odkaz:
https://doaj.org/article/e14f8a43523c431fb84819bdb734b72a
Autor:
Russell C Dale, Simon Rinaldi, Sophia Michael, David Bennett, James Varley, Yaacov Anziska, Monika Hofer, Sudarshini Ramanathan, Fabienne Brilot, Alexander Davies, Mandy Tseng, Sofija Paneva, Andreas Themistocleous, Ana Candalija, John Dawes
Publikováno v:
BMJ Neurology Open, Vol 3, Iss Suppl 1 (2021)
Externí odkaz:
https://doaj.org/article/0480124435734f1a94ed1e80963e4f00
Autor:
Emily Feneberg, David Gordon, Alexander G. Thompson, Mattéa J. Finelli, Ruxandra Dafinca, Ana Candalija, Philip D. Charles, Imre Mäger, Matthew J. Wood, Roman Fischer, Benedikt M. Kessler, Elizabeth Gray, Martin R. Turner, Kevin Talbot
Publikováno v:
Neurobiology of Disease, Vol 144, Iss , Pp 105050- (2020)
TDP-43 pathology is a key feature of amyotrophic lateral sclerosis (ALS), but the mechanisms linking TDP-43 to altered cellular function and neurodegeneration remain unclear. We have recently described a mouse model in which human wild-type or mutant
Externí odkaz:
https://doaj.org/article/d8e57a13e21d47cfb4d7b1b8b23465d9
Autor:
Ana Candalija, Thomas Scior, Hans-Richard Rackwitz, Jordan E. Ruiz-Castelan, Ygnacio Martinez-Laguna, José Aguilera
Publikováno v:
Molecules, Vol 26, Iss 13, p 3988 (2021)
This article presents experimental evidence and computed molecular models of a potential interaction between receptor domain D5 of TrkB with the carboxyl-terminal domain of tetanus neurotoxin (Hc-TeNT). Computational simulations of a novel small cycl
Externí odkaz:
https://doaj.org/article/5c5c500ec74f4522ad53b120491fe19a
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68055 (2013)
Tetanus toxin (TeTx) is the protein, synthesized by the anaerobic bacteria Clostridium tetani, which causes tetanus disease. TeTx gains entry into target cells by means of its interaction with lipid rafts, which are membrane domains enriched in sphin
Externí odkaz:
https://doaj.org/article/8ffb6f2216ff4d4e9e73e5b6b6900fe3
Autor:
Nienke Ruijter, Matthew Boyles, Marie Carrière, Alberto Katsumiti, Ana Candalija, Joan Cabellos, Rafael Ayerbe, Isabel Rodriguez, Jessica Marshall, Flemming Cassee, Hedwig Braakhuis
Publikováno v:
Annals of Work Exposures and Health. 67:i67-i68
The concept of safe-by-design (SbD) can help toxicologists and risk assessors to keep pace with the rapidly expanding field of nanotechnology. As part of SbD, the hazard potential of a new nanomaterial (NM) is identified at the first stages of produc
Autor:
Prasanth Sivakumar, Jack Humphrey, Keith A. Josephs, Mercedes Prudencio, E. Aubrey Thompson, Kevin Talbot, Bjorn Oskarsson, Hemali Phatnani, Leonard Petrucelli, Ana Candalija, David S. Knopman, Pietro Fratta, Casey Cook, Yari Carlomagno, Cristhoper H. Fernandez De Castro, Duyang Kim, Neil Graff-Radford, Maria Secrier, Siddharthan Chandran, Mei Yue, Anna-Leigh Brown, Sarah E. Hill, Bhuvaneish T. Selvaraj, Michael G. Heckman, Cristian Bodo, Karen Jansen-West, Michael E. Ward, Demetra Catalano, Samantha Fennessey, Elizabeth M. C. Fisher, Michael DeTure, Ronald C. Petersen, Dennis W. Dickson, Jia Newcombe, Isabel Hubbard, Delphine Fagegaltier, Tania F. Gendron, Ying-Chih Wang, Karen Burr, Lillian M. Daughrity, Tammaryn Lashley, J. Shi, Yuping Song, Jennifer M. Kachergus, Matthew R. Spiegel, Rosa Rademakers, Marka van Blitterswijk, Shunsuke Koga, Bradley F. Boeve, Sarah R. Pickles, Nadia Propp, Towfique Raj
Publikováno v:
J Clin Invest
No treatment for frontotemporal dementia (FTD), the second most common type of early-onset dementia, is available, but therapeutics are being investigated to target the 2 main proteins associated with FTD pathological subtypes: TDP-43 (FTLD-TDP) and
Autor:
Christopher Uy, Sophia Michael, Sofija Paneva, Sophie Binks, Russell C. Dale, Mandy Tseng, Simon Rinaldi, Andreas C. Themistocleous, Sudarshini Ramanathan, Alexander J. Davies, Yaacov Anziska, Fabienne Brilot, David L.H. Bennett, Monika Hofer, Sarosh R. Irani, Anushka Soni, John M. Dawes, James Varley, Ana Candalija
Publikováno v:
BMJ Neurology Open, Vol 3, Iss Suppl 1 (2021)
Objective We evaluated pain in leucine-rich glioma inactivated1(LGI1) and contactin-associated protein2(CASPR2)-antibody positive(Ab+) patients, to evaluate clinical associations and pathophysiology of treatable pain syndromes. Methods 108 LGI-Ab+, 3