Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ana C. Valdivia"'
Autor:
Ana C. Valdivia, Maryam Hachem, Basma Ismail, Natasha Arksey, Robert A. deKemp, Tayebeh Hadizad, Rob S. Beanlands, Jean N. DaSilva
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3931-3937
The 2-[(18)F]fluoro-3-pent-4-yn-1-yloxypyridine ([(18)F]FPyKYNE) analog of the potent non-peptide angiotensin II type 1 receptor (AT1R) blocker losartan was produced via click chemistry linking [(18)F]FPyKYNE to azide-modified tetrazole-protected los
Autor:
Miriam Estrada, Rob S. Beanlands, Ana C. Valdivia, Jean N. DaSilva, Duncan J. Stewart, Tayebeh Hadizad
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 55:57-60
[18 F]FPyKYNE-c(RGDyK) was successfully synthesized by the Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition of alkynes to azides using [18 F]FPyKYNE as a prosthetic group in an overall radiochemical yield of 12%–18% (decay-corrected) and >99.5% ch
Publikováno v:
Nuclear medicine and biology. 42(2)
Introduction Pathologic cardiac hypertrophy is one of the leading causes of sudden death from cardiac disease and involves a complex network of bio-signaling mechanisms. To date, the clinical detection and pathologic progression of hypertrophy remain
Autor:
Natasha, Arksey, Tayebeh, Hadizad, Basma, Ismail, Maryam, Hachem, Ana C, Valdivia, Rob S, Beanlands, Robert A, deKemp, Jean N, DaSilva
Publikováno v:
Bioorganicmedicinal chemistry. 22(15)
The 2-[(18)F]fluoro-3-pent-4-yn-1-yloxypyridine ([(18)F]FPyKYNE) analog of the potent non-peptide angiotensin II type 1 receptor (AT1R) blocker losartan was produced via click chemistry linking [(18)F]FPyKYNE to azide-modified tetrazole-protected los
Autor:
Paul Coletta, Rob S. Beanlands, Samantha Mason, Jeffrey Collins, Jean N. DaSilva, Kenneth R. Buckley, Ana C. Valdivia
Publikováno v:
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 68(2)
N-[(11)C]-methyl-hydroxyfasudil was synthesized as a new potential radiotracer for rho-kinases (ROCKs) via a two-step one-pot radiosynthesis. The first step was the methylation of the precursor N-Boc-hydroxyfasudil-sodium salt/benzo-15-crown-5 comple