Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ana C. Messias"'
Autor:
Enrica Zanuttigh, Kevork Derderian, Miriam A. Güra, Arie Geerlof, Ivano Di Meo, Chiara Cavestro, Stefan Hempfling, Stephanie Ortiz-Collazos, Mario Mauthe, Tomasz Kmieć, Eugenia Cammarota, Maria Carla Panzeri, Thomas Klopstock, Michael Sattler, Juliane Winkelmann, Ana C. Messias, Arcangela Iuso
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 267 (2023)
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a relentlessly progressive neurodegenerative disorder caused by mutations in the C19orf12 gene. C19orf12 has been implicated in playing a role in lipid metabolism, mitochondrial fu
Externí odkaz:
https://doaj.org/article/08ddda2e943348d48dfa60c232cfa9f8
Autor:
Enrica Zanuttigh, Kevork Derderian, Miriam A. Güra, Arie Geerlof, Ivano Di Meo, Chiara Cavestro, Stefan Hempfling, Stephanie Ortiz-Collazos, Mario Mauthe, Tomasz Kmieć, Eugenia Cammarota, Maria Carla Panzeri, Thomas Klopstock, Michael Sattler, Juliane Winkelmann, Ana C. Messias, Arcangela Iuso
Publikováno v:
Pharmaceutics 15(1), 267 (2023). doi:10.3390/pharmaceutics15010267
Pharmaceutics; Volume 15; Issue 1; Pages: 267
Pharmaceutics; Volume 15; Issue 1; Pages: 267
Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a relentlessly progressive neurodegenerative disorder caused by mutations in the C19orf12 gene. C19orf12 has been implicated in playing a role in lipid metabolism, mitochondrial fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2892404f86841fa9cd7f174609b37e62
https://mediatum.ub.tum.de/1701699
https://mediatum.ub.tum.de/1701699
Autor:
Dora Pedroso, Angelo Ferreira Chora, Eleni Kyriakou, Nadja Pejanovic, Henrique Colaço, Raffaella Gozzelino, André Barros, Katharina Willmann, Tiago Velho, Catarina F Moita, Isa Santos, Pedro Pereira, Silvia Carvalho, Filipa Batalha Martins, João A Ferreira, Sérgio Fernandes de Almeida, Vladimir Benes, Josef Anrather, Sebastian Weis, Miguel P Soares, Arie Geerlof, Jacques Neefjes, Michael Sattler, Ana C Messias, Ana Neves-Costa, Luis Ferreira Moita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b06a7148b0051ee657eea5fcde54db0
https://doi.org/10.7554/elife.77443.sa2
https://doi.org/10.7554/elife.77443.sa2
Autor:
Bomi Jung, Daniela Padula, Ingo Burtscher, Cedric Landerer, Dominik Lutter, Fabian Theis, Ana C Messias, Arie Geerlof, Michael Sattler, Elisabeth Kremmer, Karsten Boldt, Marius Ueffing, Heiko Lickert
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149477 (2016)
The seven-transmembrane receptor Smoothened (Smo) activates all Hedgehog (Hh) signaling by translocation into the primary cilia (PC), but how this is regulated is not well understood. Here we show that Pitchfork (Pifo) and the G protein-coupled recep
Externí odkaz:
https://doaj.org/article/86f08bc5cede4d7abec05336c59f2043
Autor:
Peter Baumann, Ana C. Messias, Annette Feuchtinger, Eleni Kyriakou, Sonja C. Schriever, Paul T. Pfluger, Matthias H. Tschöp, Axel Walch, Katrin Pfuhlmann, Luke Harrison
Publikováno v:
International Journal of Obesity (2005)
Int. J. Obes. 43, 1305-1318 (2019)
Int. J. Obes. 43, 1305-1318 (2019)
Background/objectives Individuals carrying loss-of-function gene mutations for the adipocyte hormone leptin are morbidly obese, but respond favorably to replacement therapy. Recombinant leptin is however largely ineffective for the vast majority of o
Autor:
Jacques Neefjes, Josef Anrather, Vladimir Benes, Luis F. Moita, Michael Sattler, Sebastian Weis, André Barros, Raffaella Gozzelino, Ângelo Chora, Henrique G. Colaço, Miguel P. Soares, Arie Geerlof, Pedro Pereira, Eleni Kyriakou, Isa Santos, Nadja Pejanovic, Katharina L. Willmann, Catarina Moita, Tiago R. Velho, Sérgio F. de Almeida, Dora Pedroso, João A. Ferreira, Filipa Batalha Martins, Sílvia Carvalho, Ana C. Messias, Ana Neves-Costa
Publikováno v:
SSRN Electronic Journal.
Anthracyclines are among the most used and effective anticancer drugs. Their activity has been attributed to DNA double-strand breaks resulting from topoisomerase II poisoning and to eviction of histones from select sites in the genome. Here we show
Autor:
Michael Sattler, Sara Marie Øie Solbak, Ralf Stehle, Anders Bach, Ana C. Messias, Arie Geerlof, Carlo Camilloni, Alexander Jussupow
Poly-ubiquitin chains are flexible multidomain proteins, whose conformational dynamics enable their molecular recognition by a large number of partners in multiple biological pathways. By using alternative linkage, it is possible to obtain poly-ubiqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa307af2d765e9499aa09eb9242daeb
https://doi.org/10.1101/2020.04.14.041327
https://doi.org/10.1101/2020.04.14.041327
Autor:
Aphrodite Kapurniotu, Ana C. Messias, Matthias J. Feige, Zheng Niu, Bernd Reif, Yonatan G. Mideksa, Chen Qian, Li-Mei Yan, Carlo Camilloni, Markus Fleisch, Don C. Lamb, Alexander Jussupow, Elke Prade, Michael Sattler, Kathleen Hille, Eleni Malideli, Riddhiman Sarkar
Publikováno v:
Angewandte Chemie (International Ed. in English)
Adv. Mater. 59, 5820-5830 (2020)
Angew. Chem.-Int. Edit. 59, 2-13 (2020)
Adv. Mater. 59, 5820-5830 (2020)
Angew. Chem.-Int. Edit. 59, 2-13 (2020)
Designed peptides derived from the islet amyloid polypeptide (IAPP) cross‐amyloid interaction surface with Aβ (termed interaction surface mimics or ISMs) have been shown to be highly potent inhibitors of Aβ amyloid self‐assembly. However, the m
Autor:
Arcangela Iuso, Nicola A. Grzeschik, Holger Prokisch, Iris Barshack, Muhamad Kumbar, Bart Kanon, Thomas Schwarzmayr, Gal Dubnov-Raz, Dorothea Haas, Riccardo Berutti, Bader Alhaddad, Marit Wiersma, Zeev Perles, Ben Pode-Shakked, Georg F. Hoffmann, Mathias Grigat, Tal Tirosh, Caterina Terrile, Elisa Mastantuono, Tim M. Strom, Jürgen G. Okun, Marina Rubinshtein, Matthias C. Braunisch, Yair Anikster, Shachar Abudi, Camilla Avivi, Ana C. Messias, Amir Vardi, Brundel Bianca Johanna Josephina Maria, Ody C. M. Sibon, Eran Eyal, Dina Marek-Yagel, Tobias B. Haack, Yishay Salem, Thomas Meitinger, A Volkov, Ortal Barel, Hans Joachim Schüller
Publikováno v:
American Journal of Human Genetics, 102(6), 1018-1030. CELL PRESS
Am. J. Hum. Genet. 102, 1018-1030 (2018)
The American Journal of Human Genetics
Iuso, A, Wiersma, M, Schüller, H J, Pode-Shakked, B, Marek-Yagel, D, Grigat, M, Schwarzmayr, T, Berutti, R, Alhaddad, B, Kanon, B, Grzeschik, N A, Okun, J G, Perles, Z, Salem, Y, Barel, O, Vardi, A, Rubinshtein, M, Tirosh, T, Dubnov-Raz, G, Messias, A C, Terrile, C, Barshack, I, Volkov, A, Avivi, C, Eyal, E, Mastantuono, E, Kumbar, M, Abudi, S, Braunisch, M, Strom, T M, Meitinger, T, Hoffmann, G F, Prokisch, H, Haack, T B, Brundel, B J J M, Haas, D, Sibon, O C M & Anikster, Y 2018, ' Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy ', American journal of human genetics, vol. 102, no. 6, pp. 1018-1030 . https://doi.org/10.1016/j.ajhg.2018.03.022
American journal of human genetics, 102(6), 1018-1030. Cell Press
Am. J. Hum. Genet. 102, 1018-1030 (2018)
The American Journal of Human Genetics
Iuso, A, Wiersma, M, Schüller, H J, Pode-Shakked, B, Marek-Yagel, D, Grigat, M, Schwarzmayr, T, Berutti, R, Alhaddad, B, Kanon, B, Grzeschik, N A, Okun, J G, Perles, Z, Salem, Y, Barel, O, Vardi, A, Rubinshtein, M, Tirosh, T, Dubnov-Raz, G, Messias, A C, Terrile, C, Barshack, I, Volkov, A, Avivi, C, Eyal, E, Mastantuono, E, Kumbar, M, Abudi, S, Braunisch, M, Strom, T M, Meitinger, T, Hoffmann, G F, Prokisch, H, Haack, T B, Brundel, B J J M, Haas, D, Sibon, O C M & Anikster, Y 2018, ' Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy ', American journal of human genetics, vol. 102, no. 6, pp. 1018-1030 . https://doi.org/10.1016/j.ajhg.2018.03.022
American journal of human genetics, 102(6), 1018-1030. Cell Press
Coenzyme A (CoA) is an essential metabolic cofactor used by around 4% of cellular enzymes. Its role is to carry and transfer acetyl and acyl groups to other molecules. Cells can synthesize CoA de novo from vitamin B5 (pantothenate) through five conse
Autor:
Arie Geerlof, Karl-Werner Schramm, Ana C. Messias, Oliver Plettenburg, Eleni Kyriakou, Sonja C. Schriever, Stephanie E. Simonds, Garron T. Dodd, Michael A. Cowley, Tony Tiganis, Michael Sattler, Matthias H. Tschöp, Dominik Lenhart, Paul T. Pfluger, Stefanie Schmidt, Meri De Angelis, Katrin Pfuhlmann
Publikováno v:
Journal of medicinal chemistry. 61(24)
Celastrol is a natural pentacyclic triterpene used in traditional Chinese medicine with significant weight-lowering effects. Celastrol-administered mice at 100 μg/kg decrease food consumption and body weight via a leptin-dependent mechanism, yet its