Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ana C. M. Omoto"'
Autor:
Xuan Li, Zhen Wang, Alan J. Mouton, Ana C. M. Omoto, Alexandre A. da Silva, Jussara M. do Carmo, Ji Li, John E. Hall
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)
Background Sesn2 (Sestrin2) is a stress‐induced protein that provides protective effects during myocardial ischemia and reperfusion (I/R) injury, while endoplasmic reticulum (ER) stress may be a pivotal mediator of I/R injury. The goal of this stud
Externí odkaz:
https://doaj.org/article/cc6fb2343f3d44e6802986a84ec00bec
Autor:
Ana C. M. Omoto, Conner C. Earl, Alyssa M. Richards, Karthik Annamalai, Benjamin Nelson, John E. Hall, Craig J. Goergen, Alexandre A. daSilva
Publikováno v:
Physiological Reports, Vol 12, Iss 14, Pp n/a-n/a (2024)
Abstract Two‐dimensional ultrasound (2DUS) echocardiography is the main noninvasive method used to evaluate cardiac function in animal models of myocardial infarction (MI). However, 2DUS echocardiography does not capture regional differences in car
Externí odkaz:
https://doaj.org/article/1aa23c25a6a84f24af04eeffaecd6d52
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
Recent evidence from our lab and others suggests that metabolic reprogramming of immune cells drives changes in immune cell phenotypes along the inflammatory-to-reparative spectrum and plays a critical role in mediating the inflammatory responses to
Externí odkaz:
https://doaj.org/article/05f813b272194508ba4cbf68393801b8
Autor:
Renata M. Lataro, Davi J. A. Moraes, Fabio N. Gava, Ana C. M. Omoto, Carlos A. A. Silva, Fernanda Brognara, Lais Alflen, Vânia Brazão, Rafaela Pravato Colato, José Clóvis do Prado, Anthony P. Ford, Helio C. Salgado, Julian F. R. Paton
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Despite medications, heart failure worsens with time with many patients dying within five years of diagnosis. Here the authors show that blocking purinergic receptors in the carotid body stops heart failure progression, improves its function, reduces
Externí odkaz:
https://doaj.org/article/e48a184e40354b858155e387d19d724e
Autor:
Alan J. Mouton, Nikaela M. Aitken, Sydney P. Moak, Jussara M. do Carmo, Alexandre A. da Silva, Ana C. M. Omoto, Xuan Li, Zhen Wang, Alexandra C. Schrimpe-Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, John E. Hall
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionMetabolic reprogramming from glycolysis to the mitochondrial tricarboxylic acid (TCA) cycle and oxidative phosphorylation may mediate macrophage polarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. We hypothesi
Externí odkaz:
https://doaj.org/article/5ddb9397e379446ebc06b0ae59b7d981
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Macrophages play critical roles in mediating and resolving tissue injury as well as tissue remodeling during cardiorenal disease. Altered immunometabolism, particularly macrophage metabolism, is a critical underlying mechanism of immune dysfunction a
Externí odkaz:
https://doaj.org/article/ca52ae620eca47f180159bee7db05ddc
Autor:
Ana C. M. Omoto, Jussara M. do Carmo, Benjamin Nelson, Nikaela Aitken, Xuemei Dai, Sydney Moak, Elizabeth Flynn, Zhen Wang, Alan J. Mouton, Xuan Li, John E. Hall, Alexandre A. da Silva
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 21 (2022)
Background Therapeutic strategies for preventing paradoxical reperfusion injury after myocardial ischemia are limited. We tested whether central nervous system actions of leptin induce important protective effects on cardiac function and metabolism a
Externí odkaz:
https://doaj.org/article/38d6df726bf24332a2f6cb009244e4ba
Autor:
Xuan Li, Elizabeth R. Flynn, Jussara M. do Carmo, Zhen Wang, Alexandre A. da Silva, Alan J. Mouton, Ana C. M. Omoto, Michael E. Hall, John E. Hall
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Clinical trials showed that sodium-glucose cotransporter 2 (SGLT2) inhibitors, a class of drugs developed for treating diabetes mellitus, improve prognosis of patients with heart failure (HF). However, the mechanisms for cardioprotection by SGLT2 inh
Externí odkaz:
https://doaj.org/article/5c3d55b7b8f940c581124f40ce8f2483
Autor:
Xuan Li, Qingguo Lu, Yunguang Qiu, Jussara M. do Carmo, Zhen Wang, Alexandre A. da Silva, Alan Mouton, Ana C. M. Omoto, Michael E. Hall, Ji Li, John E. Hall
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 6 (2021)
Background We determined if the sodium glucose co‐transporter 2 inhibitor empagliflozin attenuates pressure overload‐induced heart failure in non‐diabetic mellitus mice by direct cardiac effects and the mechanisms involved. Methods and Results
Externí odkaz:
https://doaj.org/article/06d54fe46ce34956bd6c16e9fee86fdf
Autor:
Jussara M. do Carmo, Elizabeth R. Flynn, Sydney P. Moak, Alexandre A. da Silva, John E. Hall, Nikaela M. Aitken, Ana C M Omoto, Xuan Li, Alan J. Mouton, Zhen Wang
Publikováno v:
J Mol Cell Cardiol
Myocardial infarction (MI) is one of the leading causes of mortality and cardiovascular disease worldwide. MI is characterized by a substantial inflammatory response in the infarcted left ventricle (LV), followed by transition of quiescent fibroblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c927857ef5d3f249b5bc2d8e8a5a02
https://doi.org/10.1016/j.yjmcc.2021.05.008
https://doi.org/10.1016/j.yjmcc.2021.05.008