Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ana C. D'Alessio"'
Autor:
Ana C. D’Alessio, Zi Peng Fan, Katherine J. Wert, Petr Baranov, Malkiel A. Cohen, Janmeet S. Saini, Evan Cohick, Carol Charniga, Daniel Dadon, Nancy M. Hannett, Michael J. Young, Sally Temple, Rudolf Jaenisch, Tong Ihn Lee, Richard A. Young
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 763-775 (2015)
Hundreds of transcription factors (TFs) are expressed in each cell type, but cell identity can be induced through the activity of just a small number of core TFs. Systematic identification of these core TFs for a wide variety of cell types is current
Externí odkaz:
https://doaj.org/article/047995cce35243f7b90bc348980aa00d
Autor:
John P. Cassady, Ana C. D’Alessio, Sovan Sarkar, Vardhan S. Dani, Zi Peng Fan, Kibibi Ganz, Reinhard Roessler, Mriganka Sur, Richard A. Young, Rudolf Jaenisch
Publikováno v:
Stem Cell Reports, Vol 3, Iss 6, Pp 948-956 (2014)
Overexpression of transcription factors has been used to directly reprogram somatic cells into a range of other differentiated cell types, including multipotent neural stem cells (NSCs), that can be used to generate neurons and glia. However, the abi
Externí odkaz:
https://doaj.org/article/ff877594372543e19efc4c16d32654c6
Autor:
Jijun Cheng, Shangqin Guo, Suning Chen, Stephen J. Mastriano, Chaochun Liu, Ana C. D’Alessio, Eriona Hysolli, Yanwen Guo, Hong Yao, Cynthia M. Megyola, Dan Li, Jun Liu, Wen Pan, Christine A. Roden, Xiao-Ling Zhou, Kartoosh Heydari, Jianjun Chen, In-Hyun Park, Ye Ding, Yi Zhang, Jun Lu
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 471-481 (2013)
The Ten-Eleven-Translocation 2 (TET2) gene, which oxidates 5-methylcytosine in DNA to 5-hydroxylmethylcytosine (5hmC), is a key tumor suppressor frequently mutated in hematopoietic malignancies. However, the molecular regulation of TET2 expression is
Externí odkaz:
https://doaj.org/article/c416e760f40d4498874d380c5bb59077
Autor:
In-Hyun Park, Stephen Mastriano, Cynthia M. Megyola, Yanwen Guo, Chaochun Liu, Hong Yao, Jianjun Chen, Wen Pan, Ye Ding, Kartoosh Heydari, Suning Chen, Jijun Cheng, Jun Lu, Jun Liu, Shangqin Guo, Dan Li, Ana C. D’Alessio, Eriona Hysolli, Yi Zhang, Xiao-Ling Zhou, Christine Roden
Publikováno v:
Cell Reports, Vol 5, Iss 2, Pp 471-481 (2013)
Summary The Ten-Eleven-Translocation 2 ( TET2 ) gene, which oxidates 5-methylcytosine in DNA to 5-hydroxylmethylcytosine (5hmC), is a key tumor suppressor frequently mutated in hematopoietic malignancies. However, the molecular regulation of TET2 exp
Autor:
Yi Zhang, Ana C. D’Alessio, Shinsuke Ito, Keji Zhao, Kairong Cui, Yi E. Sun, Zhibin Wang, Hao Wu, Kai Xia
Publikováno v:
Nature. 473:389-393
The modified DNA base 5-hydroxymethylcytosine (5hmC), sometimes called the sixth base, is present in the mammalian genome where it is generated by oxidation of 5-methylcytosine (5mC; the fifth base) by enzymes of the Tet family. Four papers in this i
Publikováno v:
Nature. 466:1129-1133
DNA methylation is one of the best-characterized epigenetic modifications. Although the enzymes that catalyse DNA methylation have been characterized, enzymes responsible for demethylation have been elusive. A recent study indicates that the human TE
Autor:
Sergiy Dymov, Moshe Szyf, Benoit Labonté, Ana C. D'Alessio, Aya Sasaki, Patrick O. McGowan, Gustavo Turecki, Michael J. Meaney
Publikováno v:
Nature Neuroscience. 12:342-348
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse alters HPA stress responses and increases the risk of suicide. We exami
Publikováno v:
Endocrinology. 149:3095-3108
Paired-like homeodomain transcription factors (PITX) regulate the activity of pituitary hormone-encoding genes. Here, we examined mechanisms through which the family of PITX proteins control murine FSH β-subunit (Fshb) transcription. We observed tha
Autor:
Ana C. D’Alessio, Makiko Nakagawa, Chao Yu, Keiko Nakayama, Yanbao Yu, Yue Xiong, Heng-Yu Fan, Xian Chen, Tadashi Nakagawa, Lei Lv
DNA methylation at the C-5 position of cytosine (5mC) regulates gene expression and plays pivotal roles in various biological processes. The TET dioxygenases catalyze iterative oxidation of 5mC, leading to eventual demethylation. Inactivation of TET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ec9b4eea8ae003c7ffb9f7438b3020
Autor:
Moshe Szyf, Ana C. D'Alessio
Publikováno v:
Biochemistry and Cell Biology. 84:463-466
The epigenome, which comprises chromatin, associated proteins, and the pattern of covalent modification of DNA by methylation, sets up and maintains gene expression programs. It was originally believed that DNA methylation was the dominant reaction i