Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Ana C Liberman"'
1
Akademický článek
Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function.
Autor: Fernando Aprile-Garcia, Michael W Metzger, Marcelo Paez-Pereda, Herbert Stadler, Matías Acuña, Ana C Liberman, Sergio A Senin, Juan Gerez, Esteban Hoijman, Damian Refojo, Mišo Mitkovski, Markus Panhuysen, Walter Stühmer, Florian Holsboer, Jan M Deussing, Eduardo Arzt
Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151862 (2016)
The P2X7 receptor is a member of the P2X family of ligand-gated ion channels. A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with m
Externí odkaz: https://doaj.org/article/c7a2c0f6da22409e92bac38cbfde733e
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2
Akademický článek
Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells.
Autor: Ana C Liberman, Maria Antunica-Noguerol, Viviane Ferraz-de-Paula, Joao Palermo-Neto, Carla N Castro, Jimena Druker, Florian Holsboer, Marcelo J Perone, Sarah Gerlo, Karolien De Bosscher, Guy Haegeman, Eduardo Arzt
Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35155 (2012)
BACKGROUND: Compound A (CpdA) is a dissociating non-steroidal glucocorticoid receptor (GR) ligand which has anti-inflammatory properties exerted by down-modulating proinflammatory gene expression. By favouring GR monomer formation, CpdA does not enha
Externí odkaz: https://doaj.org/article/47f7aca61d81467b8751289ac66e973d
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4
Stress-Related Brain Neuroinflammation Impact in Depression: Role of the Corticotropin-Releasing Hormone System and P2X7 Receptor
Autor: Ana C. Liberman, Jan M. Deussing, Maria Belén Ugo, Eduardo Arzt, Paula A. dos Santos Claro, Susana Silberstein
Publikováno v: Neuroimmunomodulation. 28:52-60
Depression and other psychiatric stress-related disorders are leading causes of disability worldwide. Up to date, treatments of mood disorders have limited success, most likely due to the multifactorial etiology of these conditions. Alterations in in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7d857d8ae6c274bee4f38b001654f1
https://doi.org/10.1159/000515130
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5
Tricyclic antidepressants target FKBP51 SUMOylation to restore glucocorticoid receptor activity
Autor: Maia L. Budziñski, Clara Sokn, Romina Gobbini, Belén Ugo, María Antunica-Noguerol, Sergio Senin, Thomas Bajaj, Nils C. Gassen, Theo Rein, Mathias V. Schmidt, Elisabeth B. Binder, Eduardo Arzt, Ana C. Liberman
Publikováno v: Molecular psychiatry. 27(5)
FKBP51 is an important inhibitor of the glucocorticoid receptor (GR) signaling. High FKBP51 levels are associated to stress-related disorders, which are linked to GR resistance. SUMO conjugation to FKBP51 is necessary for FKBP51's inhibitory action o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a1f28759633840a261fc15c7973db0
https://pubmed.ncbi.nlm.nih.gov/35256747
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6
SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress
Autor: Eduardo Arzt, Ana C. Liberman, Clara Sokn, Maia L. Budziñski, Maria Belén Ugo, Romina Paula Gobbini
Publikováno v: Steroids. 153:108520
In order to adequately respond to stressful stimuli, glucocorticoids (GCs) target almost every tissue of the body. By exerting a negative feedback loop in the hypothalamic-pituitary-adrenal (HPA) axis GCs inhibit their own synthesis and restore homeo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2751d38b5c484586ba15f166f8489f8
https://doi.org/10.1016/j.steroids.2019.108520
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7
Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms
Autor: Mercedes Lasaga, Ana C. Liberman, Terrence Deak, Heather C. Brenhouse, Pablo Nicolás Surkin
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during the early stages of life, such as infancy or adolescence, can induce adaptations in multiple physiological systems, including the reproductiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280f1365090875604a20ba183788e474
http://doi.wiley.com/10.1111/jne.12602
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8
Neuroimmune and Inflammatory Signals in Complex Disorders of the Central Nervous System
Autor: Emiliano Trias, Ana C. Liberman, Luana da Silva Chagas, Marissol Dos Santos Pereira, Cecilia Hedin-Pereira, Claudio Alberto Serfaty, Damian Refojo, Pablo Trindade
Publikováno v: Neuroimmunomodulation. 25(5-6)
An extensive microglial-astrocyte-monocyte-neuronal cross talk seems to be crucial for normal brain function, development, and recovery. However, under certain conditions neuroinflammatory interactions between brain cells and neuroimmune cells influe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d2bb99fac355acef0907d91845a4a5
https://pubmed.ncbi.nlm.nih.gov/30517945
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9
Regulatory and mechanistic actions of glucocorticoids on T and inflammatory cells
Autor: Romina Paula Gobbini, Anja Steininger, Maia L. Budziñski, Eduardo Arzt, Clara Sokn, Ana C. Liberman
Publikováno v: Frontiers in Endocrinology, Vol 9 (2018)
Frontiers in Endocrinology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor (GR) activity is instrume
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89006ba6725bd7a7c10ab2f28bcf4aae
https://www.frontiersin.org/articles/10.3389/fendo.2018.00235/full
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10
Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes
Autor: Marcelo J. Perone, Ana C. Liberman, A. E. Barcala Tabarrozzi, J Winnewisser, D A Paz, M Antunica Noguerol, C N Castro, Ricardo A Dewey, María L. Gimeno
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Type 1 diabetes (T1DM) is a T cell-mediated autoimmune disease that selectively destroys pancreatic β cells. The only possible cure for T1DM is to control autoimmunity against β cell-specific antigens. We explored whether the natural compound curcu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0855cd7fb95d96fabc5e2c5f6b9fbea5
https://doi.org/10.1111/cei.12322
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